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Renal Section Chpt 28
Pathophysiology
60
Pharmacology
Professional
11/07/2010

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Cards

Term
Name the two primary functions of the kidney.
Definition

1. Regulate the volume of the body

2. Balance the water & salts and acids & bases

Term
Name 3 things gluconeogenesis assist the kidneys with
Definition

1. Production of rennin (regulate blood pressure)

2. Production of erythropoietin

3. Activation of Vitamin D

Term
The Urinary Bladder provides ....
Definition
a temporary storage reservoir for urine.
Term
Paired Ureters...
Definition
transports urine from kidney to the bladder
Term
Urethra transports urine....
Definition
from the bladder out of the body
Term
The kidneys lie in what typre of position in the superior lumbar region
Definition
Retroperitoneal Position
Term
Which kindey is slightly lower than the other?
Definition
Right Kidney
Term

The lateral surface of the kidney is con___?

The medial surface if con___?

Definition

Convex

Concave

Term
The renal hilus leads to the
Definition
Renal sinus
Term
Fibrous capsule that prevents kidney infection
Definition
Renal Capsule
Term
Fatty mass that cushions the kidney and helps attach it to the body
Definition
Adipose capsule
Term
Outer layer of dense fibrous connective tisse that anchors the kidney
Definition
Renal Fascia
Term
The nerve supply is via the
Definition
Renal plexus
Term
How many nephrons are in each kidney?
Definition
1.2 million
Term
What are nephrons main function?
Definition
form urine
Term
Openings between the foot processses that allow filtrate to pass into the capsular space.
Definition
Filtration Slits
Term
What does PCT stand for?
Definition
Proximal convoluted tubule
Term
The PCT are composed of what type of cells
Definition
Cuboidal Cells and numerous microvilli and mitochondria
Term
PCT main purpose is to
Definition

1. Resbsorb water

2. Reabsorb solutes from filtrate

3. Secretes substances

Term
The Loop of Henle thin segment is composed of? and thick segment is composed of?
Definition

thin - squamous cells

thick - cuboidal to columna cells

Term
What does DCT stand for?
Definition
Distal Convoluted tubule
Term
DCT are cuboidal cells without
Definition
microvilli
Term
The main difference between PCT and DCT is
Definition
DCT function more in SECRETION more than Reabsorption
Term
What are the 2 important cells found near the DCT?
Definition
Intercalated cells and Principle cells.
Term
  • Cuboidal cells without microvilli
  • Function in maintaining the acid-base balance of the body
Definition
Intercalated Cells
Term
  • Cuboidal cells without microvilli
  • Help maintain the body's water & salt balance

 

Definition
Principal Cells
Term
85% of nephrons are ______ nephrons and they are located in the _______?
Definition
Cortical, cortex
Term
juxtamedullary nephrons are located in the?
Definition
Cortex-medulla junction
Term
These nephrons are involved in the production of concentrated urine
Definition
Juxtamedullary nephrons
Term
Name the capillary beds of the nephron
Definition
Glomerulus and the Peritubular
Term
Each glomerulus arteriole is fed by an ________ arteriole and drained by an _________ arteriole
Definition
Afferent arteriole and Efferent Arteriole
Term
Blood pressure of the glomerulus is high because?
Definition
Arterioles are high-resistance vessels and they have larger diameters
Term
Peritubular beds are
Definition
low-pressure beds
Term
Resistance in Afferent Arterioles protects
Definition
glomeruli from fluctuations in systemic blood pressure
Term
Resistance in Effernt Arterioles reinforces
Definition
high glomerular pressure and reduces hydrostatic pressure in peritubular capillaries
Term
A drop in filtration pressure stimulates Juxtaglomerular apparatus and releases
Definition
Renin and Erythropoietin
Term
The only blood supply to the medulla is
Definition
the Vasa recta
Term
Together the juxtaglomerular cells and macula densa cells form the
Definition
juxtaglomerulus apparatus
Term
When the bladder accumulates 250 - 300 ml of urine, the bladder contracts and the internal urethral sphincter relaxes through activation of the spinal reflex arc is known as
Definition
the micrturition reflex
Term
the filtration of the plasma per unit of time is known as the
Definition
glomerular filtration rate
Term
what does GFR stands for?
Definition
glomerular filtration rate
Term
what does RBF stands for?
Definition
Renal Blood Flow
Term
The GFR is directly related to the
Definition
Renal Blood Flow
Term
If arterial pressur decreases and vascular resistance increases then, _______ falls
Definition
Renal Blood Flow
Term
The nephron can perform 4 functions simultaneously
Definition
  1. filters plasma at glomerulus
  2. reabsorbs and secretes substances
  3. forms a filtrate of protein free plamsa
  4. regulates the filtrate to maintain body fluid volume.
Term

Reduction in GFR

1. Homeostasis

2. Homeostasis disturbed (decrease GFR)

3. Renin Release

4.

5. Elevation of blood pressure & volume

6.

Definition

4. Angiotensin activation

6. Homeostasis Restored (increases GFR)

Term
What does sympathetic activation do? (3 things)
Definition
  • Produce powerful vasoconstriction of afferent arterioles
  • Change regional pattern of blood flow
  • stimulate the release of renin
Term
Active transport in the renal tubules can be limited as the carrier molecules become saturated, a phenomenon known as
Definition
transport maximum
Term
Active reabsorption of sodium is the primary function of the
Definition
proximal tubule
Term
In tubular transport hydrogen ions are actively exchanged for
Definition
sodium ions
Term
the proximal tubule is lined with microvilli to
Definition
increase the surface area and enhance reabsorption
Term
the hairpin looh of Henle transport solutes and water, contributing to the __________ state of the medulla
Definition
hypertonic
Term
Renal Blood Flow is what % of the cardiac output?
Definition
20% - 25%
Term
the renin-angiotensin system is a ...
Definition
regulatory of the renal blood flow
Term

the distal tubules actively Reabsorp _____ and Secrete _____ & _____

to regulate acid & base balance

Definition

Sodium

 

Potassium & hydrogen

Term

If the GFR is too high

 

 

Definition
needed substances cannot be reabsorbed quickly enough and are lost in the urine
Term
when everything is reabsorbed, including wastes that are normally disposed of the GFR is
Definition
too low
Term
What are the 2 intrinsic controls?
Definition
Myogenic and flow-dependent tubuloglomerulare feedback
Term
which intrinsic control responds to changes in pressure in the renal blood vessels
Definition
myogenic
Term
which intrinsic control senses changes in the juxtaglomerular apparatus
Definition
flow0dependent tubuloglomerular feedback
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