Term
| Efferent Arteries flow which way? |
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Definition
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Term
| Afferent Arteries flow which way? |
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Definition
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Term
| How kidney filtration works |
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Definition
| In the glomerulus, small ions and water are filtered out of the AFFERENT arterioles into the glomerular space. |
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Term
| How does secretion work in kidney? |
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Definition
| From capillaries into the renal tubule |
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Term
| How does reabsorption work in the kidney |
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Definition
| From the tubules back into the peritubular capillaries |
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Term
| From what perspective should secretion and absorption be thought of when considering the kidney? |
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Definition
| From the perspective of the glomerular capillaries... As secretion occurs, fluid and ions are secreted from the capillary to the tubule and as reabsorption occurs, fluid is being reabsorbed into the capillary from the tubule. |
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Term
How much water is filtered / day?
Excreted?
% Reabsorbed? |
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Definition
180 liters/day
1.5 liters
99% Reabsorbed |
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Term
How much urea filtered / day?
Secreted? |
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Definition
56 grams
28 grams excreted (50%) |
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Term
| Glucose, Sodium and Potassium, nearly completely reabsorbed.. See reverse for actual figures |
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Definition
| Potassium actually 86% is reabsorbed, Glucose 100% and Na 99.4% |
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Term
| Function of Calcitriol, EPO, Renin |
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Definition
| Calcitriol-Regulates Calcium and Phosphate. EPO - stimulates RBC development in marrow. Renin helps control BP / constricts vessels. |
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Term
| Renal Metabolic function? |
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Definition
| Gluconeogenesis: Produce glucose from AA's during long fasts |
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Term
Glomerular Filtration Rate is figured how?
What's normal? |
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Definition
Volume / Time
Normal = 125ml/minute, 180L/Day
Total blood plasma volume is ony 3L, meaning plasma is filtered 60 X Day! |
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Term
Renal Blood Flow rate?
Renal Plasma Flow rate? |
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Definition
1.1 L/min, or 20% of Cardiac Output which is 5 Liters / Minute
RPF based on hematocrit |
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Term
| Test Question: Layers of the Glomerulus? |
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Definition
| Endothelial layer (pores), Basement Membrane, Podocytes (slits) between processes. |
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Term
| Fraction of RPF (Renal Plasma Flow) filtered? |
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Definition
20% calculated based on GFR / RPF
RPF (renal plasma flow) is calculated based on hematocrit.
GFR is based on amount of filtrate formed over time. |
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Term
| Glomerular filtration determined by 3 factors? |
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Definition
SIZE:Large molecules/proteins don't pass through membrane.
ELECTRICAL CHARGE: Basement Membrane is NEGATIVELY charged (Proteins).
SHAPE: Rigid Globular molecules, not to fluid/flexible molecules. |
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Term
| Glomerular physical barriers to filtration found in capillary endothelial layer: |
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Definition
| Pores (Fenestrations) large enough to allow some proteins to pass, coated with "polyanionic surface glycoproteins" creating a negative charge. |
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