Term
| What is the first choice diruetic in Chronic versus Acute Hypertension |
|
Definition
Chronic: Hydrochlorothiazide
Acute: Furosemide |
|
|
Term
Mechanism of Methyl dopa
Adverse reactions to methyldopa |
|
Definition
Mech: False neurotransmitter
Adverse
Sedative
Edema
Impotence |
|
|
Term
Mechanism of Action of Clonidine?
What are the adverse effects? |
|
Definition
Alpha 2 Agonist
Adverse
Dry mouth/constipation
Edema
Impotence
|
|
|
Term
| What is the mechanism of action of Guanethidine or Guanadrel |
|
Definition
| Displacing Norepinephrine |
|
|
Term
What is the mechanism of Guanethidine/Guanadrel?
What are the adverse effects? |
|
Definition
Mech: Displace Norepi causing degradation
Adverse
Tolerance
|
|
|
Term
What is the mechanism of action of Prazosin or terazosin?
What are the adverse effects? |
|
Definition
Alpha 1 Antagonists
Adverse: Syncopy |
|
|
Term
| What is the mechanism of action of Minoxidil? |
|
Definition
| Generates NO to Vasodialate BV |
|
|
Term
What is the mechanism of minoxidil?
What are the adverse effects of Minoxidil? |
|
Definition
Mechanism: NO generation
Adverse
Hypertrichosis
Pericarditis |
|
|
Term
WHat is the mecahnism of hydralazine?
What are the adverse effects of Hydralazine and what patients exhibit these more frequently |
|
Definition
Mech: NO generation
Adverse
Tachycardia-> (Headaches, Chest Pain)
Slow Acetylators exhibit these more often |
|
|
Term
What is the mechanism of nitroprusside?
Adverse effects of Nitroprusside? |
|
Definition
Mech: NO generation
Adverse: CN poisoning |
|
|
Term
| What are routes of administration of Diazoxide and what are the effects? |
|
Definition
PO: Increase Glucose
IV: Decrease BP for 8 hrs |
|
|
Term
How does route of administration change the pharmacodynamics?
Adverse reactions to diazoxide? |
|
Definition
PO: Raise Blood Sugar
IV: hypotension
Adverse
Orthostatic Hypotension
Tachycardia |
|
|
Term
| What is the selectivity of the Ca-Ch blockers |
|
Definition
Verapamil: Cardiac
Diltiazem: Cardiac and Vascular
Nifedipine: Vascular |
|
|
Term
What is the Most fat soluble Ace-inhibitor and what is its half life
Which Ace-inhibitor is a Active and Metabolized?
Which is not Metabolized?
What are the adverse effects of Ace-inhibitors? |
|
Definition
Lisinopril and longest half life(Duration 24 hrs?)
Active and Metabolized: Captopril
Not Metabolized: Enalopril
Adverse
Angioedema
Neutropenia
Teratogen
Hyperkalemia
Renal Failure
Cough/Rash |
|
|
Term
| What are the adverse effects of Spironolactone |
|
Definition
Gynecomastia
Alopecia
Hyperkalemia |
|
|
Term
| What is the mechanism of action of Reserpin |
|
Definition
| Inhibits MgATPase depleting Norepi |
|
|
