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Details

Renal-Path
Tubulo-Interstitial Disease
17
Pathology
Graduate
10/26/2010

Additional Pathology Flashcards

 


 

Cards

Term
Histology of the PCT
Definition
Cuboidal cells with Microvilli, mitochondria and Plasmalemma Infoldings
Term
Histology of the Loop of Henle
Definition
Cuboidal with Prominent BM
Term
Histology of the DCT
Definition
Prominent Basal Plasmalemma infoldings
Term
Histology of the Collecting Duct
Definition
Cuboidal with distinct cell boarders
Term
What is the cause and complications of Acquired Renal Cystic Disease
Definition

Cause: Dialysis Patients forming Calcium Oxalate Crystal Obstructions

Complications: Hemorrhage or Carcinoma

Term
What is the impact of Glomerular disease on the tubules
Definition

Direct Autoimmune deposition

Fibrosis from ET1, PDGF, TGF-B activating fibroblasts

Term
Appearance of ATN on Biopsy
Definition
Loss of surface modifications, Swelling, Pyknosis, Karyolysis
Term
How would you identify Mercuric Chloride, CCl4, or Ethylene Glycol poisoning on Biopsy
Definition

Merc: Acidophillic Inclusions

CCl4: Lipid Isudation

Ethylene Gylcol: Oxalate Crystals and Vaculolar degeneration

 

Term
Evidence of Chronic Pyelonephritis
Definition
Tubule dilation(Maybe Thyroidization), broad scarring over a blunted calyx
Term
What are the causes of Renal Papillary Necrosis
Definition

Acute Pyelo esp in Diabetics

Analgesic Nephritis

Sickle Cell

Term
What are the signs of Interstitial Nephritis on biopsy
Definition
Polymorphous inflammation with eosinophils
Term
What are the ways to differentiate Diabetic Papillary Necrosis and Analgesic Papillary Necrosis and which has a better prognosis
Definition

Diabetic: Consistent Stage, Yellow

Analgesic: Inconsistent Stage, Brown, Calcification

Analgesic has a better prognosis

Term
What are the non renal tumors that may  affect the renal interstitium
Definition

Multiple Myeloma

Malignancy causing Hypercalcemia or Hyperuricemia

Term
What is the pathogenesis of Acute Tubular Necrosis
Definition

Tubular Obstruction by Casts

Vasoconstriction from RAAS activation

Term
What regions of the nephron are typically injured by Toxic ATN and Ischemic ATN respectively?
Definition

Toxic ATN: More diffuse Proximal injury

Ischemic: patchy Proximal and Distal injury

Term
Why is it important to diagnose the cause of ATN quickly
Definition
Can lead to Renal Failure but the process may be completely reversible
Term
What portions of the nephron are affected by the Autosomal Dominant form of Polysitic Kidney Disease and which are affected by the autosomal recessive form
Definition

Dominant: All portions

Recessive: Collecting Ducts

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