Term
| What are the homeostasis consequences of stage 4 and 5 CKD |
|
Definition
Metabolic Acidosis: Unable to excrete NH4
Hyperchloremic-> Anion-Gap Acidosis
Hyperkalemia
Anemia
Calcium Metabolism Disturbance
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Term
| What are the consequence of CKD on Calcium metabolism |
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Definition
Low Phosphate excretion activates PTH secretion(Gland Hyperplasia)
Decreased Vitamin D production
Bone degradation (Bone Buffering+PTH)
Calcification from High Phosphorous Levels
Hyperparathyroidism + Osteoporosis |
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Term
| Correction of Calcium metabolism in CKD |
|
Definition
Vitamin D and Phosphate Binders
Maybe Parathyroid resection |
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Term
| What is the treatment for Anemia in CKD |
|
Definition
| Give EPO and IV Fe to rise Hemoglobin to 10-12 not higher bc may cause death |
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Term
| What is the pathogenesis of hypertension in chronic renal failure |
|
Definition
Excessive Salt Rentention
Increases Peripheral Resistance(From RAAS) |
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Term
| At what level of GFR do the clinical consequences of Renal dysfunction become apparent |
|
Definition
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Term
| What is the main cause of morbidity and mortality in patients with CKD? |
|
Definition
| Accelerated Atherosclerosis |
|
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Term
| When is diuretic treatment of CKD edema ineffective? |
|
Definition
| At low filtration rates seen in severe kidney disease |
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|
Term
| What is Calciphylaxis and when does it occur |
|
Definition
| Painful skin calcifications seen in excessive Parathyroid levels |
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Term
| How do you treat a Uremic patient |
|
Definition
Decrease Protein and Phosphorus
Bicitra for Acidosis
Titrate Na and K
Ca and Vit D
EPO and Fe
Dose drugs according to GFR recommendations
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Term
| What compounds are added to the body through the process of hemodyalysis |
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Definition
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