Term
| What Primary Glomerulonephritis diseases presents as a Nephritic syndrome |
|
Definition
sIgA
Post-Streptococcal
Membranoproliferative (Type I)
Systemic Lupus |
|
|
Term
| What major nephrotic disease affects children? |
|
Definition
| Minimal Change Glomerulonephritis |
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|
Term
| What Primary Glomerulonephritis diseases present as a Nephrotic syndrome |
|
Definition
Membranous Glomerulonephritis
Minimal Change Glomerulonephritis
Focal Segmental Glomerulonephritis
Membranoproliferative Type 1
Diabetic |
|
|
Term
| What nephrotic disease is more common in African Amerians |
|
Definition
| Focal Segmental Glomerulonephritis |
|
|
Term
| What is the treatment for Minimal Change Glomerulonephritis and is it effective? |
|
Definition
| Corticosteroids, but adults have less remission and more recurrance |
|
|
Term
| What are the pathological variants of Focal Segmental Glomerulonephritis and what is the prognosis of each? |
|
Definition
Collapsing: Worst Prognosis
Tip: Best Prognosis
Perihilar |
|
|
Term
| What disease is the collasping variant of Focal Segmental Glomerulonephritis associated with? |
|
Definition
| Higher Prevailence in Aids patients |
|
|
Term
| What extra-renal pathologies are seen in patients with Membranous Glomerulonephritis |
|
Definition
|
|
Term
| What is the clinical course for most patients with Membranous Glomerulonephritis |
|
Definition
| Benign for 10 years with gradual progression to Chronic Renal Failure requiring dialysis. |
|
|
Term
| What other type of diseases is Membranous Glomerulonephritis associated with? |
|
Definition
|
|
Term
| Diagnosis of Membranous Glomerulonephritis |
|
Definition
EM: Subepithelial Deposits
LM: Basement Spikes between Deposits |
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|
Term
| Diagnosis of Minimal Change Glomerulonephritis |
|
Definition
| EM: Effacement of the Podocyte foot processes |
|
|
Term
| Diagnosis of Diabetic Nephropathy |
|
Definition
| Kimmelstiel-Wilson Lesion: Nodular Glomerulosclerosis |
|
|
Term
| Presentation of Membranoproliferative Glomerulonephritis |
|
Definition
|
|
Term
| Diagnosis of each type of Membranoproliferative Glomerulonephritis |
|
Definition
Type I: Subendothelial Deposits
Type II: Intramembranous Deposits |
|
|
Term
| What deficiency is commonly seen in Membranoproliferative Glomerulonephritis Type II |
|
Definition
| Complement Factor H Deficiency |
|
|
Term
| What Glomerulonephritises are associated with Hepatitis |
|
Definition
Membranous: Hep B and some Hep C
Membranoproliferative: Hep C |
|
|
Term
| Where is the major site of deposition in sIgA Glomerulonephritis |
|
Definition
| Mesangium of the Glomerulous |
|
|
Term
| What is the most common glomerulonephritis |
|
Definition
|
|
Term
| When do Post-Streptococcal and sIgA Glomerulonephritises typically present? |
|
Definition
Post-Strep: 2-3 wks after URT
sIgA: Commonly following a URT |
|
|
Term
| What are the glomerulonephritises that do not exhibit Hypocomplementemia |
|
Definition
sIgA
Goodpasture's
Anca Vasculitities
Henoch-Schonlein Purpura |
|
|
Term
| What are the Glomerulonephritites that exhibit only C3 Hypocomplementemia |
|
Definition
Post-Infectious
Endocarditis
Membranoproliferative Type 2 |
|
|
Term
| What are the glomerulonephritites that exhibit C3 and C4 Hypocomplementemias |
|
Definition
Lupus nephritis
Membranoproliferative with Cryglobulinemia |
|
|
Term
| During what decades of life does goodpasture's predominate present in? Is there a difference be Male and Females? |
|
Definition
Males: 2-3 decade
Females: 6-7 decade |
|
|
Term
| Hallmark of goodpasture's glomerulonephritis |
|
Definition
|
|
Term
| Target for Goodpasture's Ig |
|
Definition
| Alpha-3 chain of Type IV collagen |
|
|
Term
| Pauci-Immune Glomerulonephritis |
|
Definition
| Non-Ig Meadiated with 90% of patients exhibiting glomerular cresants |
|
|
Term
| What is the treatment for Membranous, Membranoproliferative, Goodpasture's, Pauci-immune, focal segmental, Minimal change Glomerulonephropathies |
|
Definition
Focal segmental: ACE/ARB's, Steroids, Cyclosporin, Mycophenolate Mofetil
Membranous: ACE/ARB's, Steroids, Cyclosporin, Mycophenolate Mofetil, Rituximab
Pauci-Immune and Goodpasture's: Plasmaphoresis, Steroids, Cyclophosphamide
Membranoproliferative: Steroids, Cyclophosphamide
Minimal Change: Steroids, Resistance-> Cyclosporin or Tacrolimus
|
|
|
Term
| Which glomerular diseases may present as RPGN |
|
Definition
Vasculitities
Goodpasture's
Lupus
Post-Strep
Endocarditis |
|
|
