Term
|
Definition
| Name given to red blood cells |
|
|
Term
|
Definition
| Production of red blood cells |
|
|
Term
|
Definition
| red blood cell precursors found in the bone marrow. |
|
|
Term
|
Definition
| Another name for red blood cell precursors. |
|
|
Term
| Red Blood Cell production |
|
Definition
| controlled by erythropoietin. Occurs in the bone marrow, myeloid stem cells become erythroblasts, they then undergo morphological changes and mature into red blood cells. Approx. 3-5 days. |
|
|
Term
|
Definition
| In the bloodstream, 2-3 million on avg, live for approx 120 days, die in spleen and are ate by macrophages. |
|
|
Term
| 6 Stages of RBC Development (CAP) |
|
Definition
Pronormoblast
Basophilic Normoblast
Polychromatophilic Normoblast
Orthochromic Normoblaast
Reticulocyte
Erythrocyte |
|
|
Term
| 6 Stages of RBC Development (ASCP) |
|
Definition
Rubriblast
Prorubricyte
Rubricyte
Metarubricyte
Reticulocyte
Erythrocyte |
|
|
Term
|
Definition
| Cell size decreases, cytoplasm changes from blue to pink, increases compared to cell size, nucleus decreases in size, disappears, changes from purplish-red to dark blue, nucleoli disappear, chromatine become coarse clumped and condensed, N/C ratio decreases. |
|
|
Term
| Pronormoblast (Rubriblast) |
|
Definition
| Cytoplasm has a deep rich blue color, 10-15um, scanty amount of cytoplasm, non-granular, nucleoli, round or slightly oval, stains less red, perinuclear HALO, in bone marrow. |
|
|
Term
| Basophilic Normoblast (Prorubricyte) |
|
Definition
| 10-15um, N/C ratio: 6:1, Cytoplasm stains more deeply than pronormoblast, scanty and non granular, nucleoli, round or slightly oval, less red, perinuclear HALO, in bone marrow. |
|
|
Term
| Polychromatophilic Normoblast (Rubricyte) |
|
Definition
| first true appearance of Hgb, last stage of cell division, 10-12um, N/C ratio 4:1. murky grey cytoplasm, moderate amount, no nucleoli, condensed and clumped chromatin, wago wheel, deeper blue, in bone marrow. |
|
|
Term
| Orthrochromic Normoblast (Metarubricyte) |
|
Definition
| Last stage with nucleus, known as nucleated RBC, 8-10um, N/C ratio 1:2, pink-orange cytoplasm, moderate amount, small, pyknotic nucleous, coarse and clumped chromatin,mostly in bone marrow. |
|
|
Term
| REticulocyte (Polychromatic Erythrocyte) |
|
Definition
| 8-8.5um, No N/C ratio, all cytoplasm, pink, slightly blue appearnace with stain, smal amounts of RNA appear as granules, irregular shape, not bioconcave, no nucleus, mostly in bone marrow. |
|
|
Term
|
Definition
| 6-8um, No N/C ratio, round bioconcave disk with distinct and smoth margins, salmon pink with a centrol pale area, in peripheral blood. |
|
|
