Term
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Definition
| Molecule that binds to a protein (Ex. first messenger binding to a receptor) |
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Term
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Definition
| Ligand that activates function (signal Transduction) |
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Term
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Definition
| Ligand that prevents function (signal Transduction) |
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Term
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Definition
| Intracellular protein that responds to an activated receptor that generates second messengers. |
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Term
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Definition
| intracellular protein that transmits the signal of an activated receptor to an effector protein |
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Term
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Definition
| Intracellular protein that lacks intrinsic enzymatic activity but contains several domains that mediate protein-protein interaction |
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Term
| How do Receptors Display specificity? |
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Definition
| By detecting signaling molecules the cell wants to detect |
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Term
| 2 types of molecular switches |
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Definition
| G-Protein Cycle & Protein Phosphorylation |
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Term
| 4 types of Cell-surface receptors |
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Definition
Ligand gated ion channel
-enzyme linked
-cytokin
-G-protien coupled |
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Term
| Ligand-Gated-ion channel action |
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Definition
| Binding of ligand changes ion permeablility of plasma membrane and allows influx or eflux of specific ions. limited to the synaptic system |
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Term
| Ligand-Gated ion channel termination |
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Definition
occurs by diffusion away from receptro
-degradation
-reuptake by presynaptic neuron |
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Term
| Enzyme-Linked Receptor ACtion |
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Definition
| Binding of ligand activates intrinsic enzymatic activity of cytoplasm. limited to endocrine and paracrine systems. |
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Term
| What is the affinity of ligands to enzyme linked receptors |
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Definition
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Term
| SH2 domain has binding affinity for what? |
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Definition
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Term
| The PTB protein domain has binding affinity for what ? |
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Definition
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Term
| The SH3 Domain has binding affinity for what? |
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Definition
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Term
| The PH domain has binding affinity for what? |
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Definition
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Term
| Receptor Tyrosin Kinase (RTK) |
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Definition
| large transmembrane protein that upon binding of ligand activates kinase activity-->autophosphorylation of tyrosine residues-->binding of signaling proteins-->MAP kinase Cascade |
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Term
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Definition
| after activation of Enzyme-linked receptor and binding of signaling protein. GTP further activates signaling molecule to activate MAPKKK--ATP-->MAPKK--ATP-->MAPK--ATP-->phosphorylation of membrane protein or phosphorylation of gene regulatory protein |
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Term
| Serine/Threonine Kinase cascade |
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Definition
Transmembrane enzyme linked protein, 1ligand activates kinase activity-2autophosphorylation
3.SMAD protein binds and is phosphorylated
4.SMAD forms DIMER with another SMAD
5.goes to nucleus and alters gene expression |
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Term
| enzyme-linked receptor termination |
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Definition
1.receptors cluster
2. vacuole forms, helped by clathrin
3. endosome forms, ligand separates from receptor
4. some receptors are degraded and some are recycled |
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Term
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Definition
| ligand binding that activates tyrosine kinases. limited to paracrine and autocrine systems |
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Term
| what are the ligands for the cytokine receptor? |
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Definition
| cytokines and some growth factors |
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Term
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Definition
1.separate subunits associated with JAkinases
2. ligand binds forming dimer
3. Bound ligand Activates JAK phospholylation
4.STATS bind
5.JAKS phospohrylate STATS
6.STATs dimerize
7. move to nucleus altering gene expression |
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Term
| Termination of Cytokine Receptors |
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Definition
-phosophatases
-SOCS
-Endocytic internalization |
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Term
| how do phosphatases terminate cytokine Receptors |
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Definition
| remove tyrosine phosphates from the receptor |
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Term
| how do SOCS proteins inhibit STAT phosphorylation |
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Definition
| by binding and inhbiting JAKS or competing with STATs for phosphotyrosine binding sites |
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Term
| G-protein coupled receptor action |
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Definition
| Binding of ligand activates 3subunit Gprotein which conveys signal to next component in pathway. limited to synaptic, endocrine, paracrine and autocrine systems. |
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Term
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Definition
-ligands get metabolized or inactivated
-receptor internalization
-receptor phosphorylation desensitizes it |
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Term
| Equilibrium dissociation constant |
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Definition
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Term
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Definition
| Receptor has high affinity for ligand |
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Term
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Definition
| receptor has a low affinity for the ligand |
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Term
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Definition
| total number of receptors |
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