Term
| lifespan of RBC, platelets |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
dense granules -- ADP, Ca2+ (activates coag cascade)
alpha granules -- vWF, fibrinogen |
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Term
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Definition
GpIb -- vWF (and vWF to collagen)
GpIIb/IIIa -- fibrinogen |
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Term
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Definition
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Term
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Definition
lysozyme
myeloperoxidase (turn pus green!!)
lactoferrin (binds iron) |
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Term
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Definition
CILK
C5a, IL-6, LB4, Kallikrein |
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Term
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Definition
major basic protein -- can cause direct tissue damage!!
histaminase/arylsulfatase -- limit mast cells |
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Term
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Definition
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Term
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Definition
NAACP
Neoplastic!!
Asthma
Allergic processes (attracted by mast cell's eosinophilic chemotactic factors!!)
Collagen vascular disease!!
Parasites |
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Term
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Definition
heparin
histamine
eosinophilic chemotactic factors |
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Term
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Definition
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Term
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Definition
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Term
| majority of circulating lymphocytes are... |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| which blood type can --> fetal hemolysis |
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Definition
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Term
| where coag factors are synthesized |
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Definition
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Term
| intrinsic pathway -- how measured, factors involved |
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Definition
PTT
all factors EXCEPT VII and XIII |
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Term
| extrinsic pathway -- how measured, factors involved |
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Definition
PT
I, II, V, VII, X
tissue factor |
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Term
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Definition
II = thrombin
I = fibrinogen |
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Term
| inactivated by antithrombin |
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Definition
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Term
| anti-phospholipid syndrome -- PT, PTT |
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Definition
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Term
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Definition
| IL-1, IL-6, TNF-alpha --> fibrinogen!! |
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Term
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Definition
| polycythemia??, sickle cell, CHF??, microcytosis, hypofibrinogenemiaa |
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Term
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Definition
liver disease
abetalipoproteinemia |
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Term
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Definition
TAIL (without I)
Thalassemias
Anemia of chronic disease
Lead poisoning |
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Term
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Definition
| megaloblastic anemia, marrow failure!! |
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Term
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Definition
| HS, autoimmune hemolysis!! |
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Term
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Definition
| bone marrow infiltration (i.e. myelofibrosis) |
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Term
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Definition
HALT said the hunter to his target
HgC
Asplenia!!
Liver disease!!
Thalassemia |
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Term
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Definition
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Term
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Definition
1. iron def anemia
2. esophageal web
3. atrophic glossitis |
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Term
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Definition
1 -- silent carrier
2 -- trait
3 -- HbH disease (beta4)
4 -- hydrops fetalis (Hb Barts -- gamma4) |
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Term
| "crew-cut" on skull x-ray |
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Definition
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Term
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Definition
point mutations --> dec. beta-globin synthesis
1 -- minor (high HbA2 -- alpha2delta2; high HbF -- alpha2gamma2)
2 -- major |
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Term
| lead poisoning -- symptoms, treatment, where do you work? |
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Definition
LEAD, SUCks to be a kid that eats lead
Lead Lines (gingivae = Burton's lines; epiphyses)
Encephalopathy, Erythrocyte basophilic stippling
Abd coli, sideroblastic Anemia
Drops (wrist and foot), Dimercaprol and EDTA for treatment
Succimer for kids treatment
battery, ammunition, radiator factories |
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Term
| treatment for sideroblastic anemia |
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Definition
| B6!! cofactor for delta-ALA synthase!! |
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Term
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Definition
folate -- high homocysteine, normal methylmalonic acid
B12 -- high homocysteine, high methylmalonic acid |
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Term
| non-megaloblastic macrocytic anemias |
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Definition
liver disease
alcoholism
reticulocytosis
5-FU, AZT, hydroxyurea |
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Term
| intravascular hemolysis vs. extravascular hemolysis |
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Definition
intra -- low haptoglobin, hemoglobin in urine
extra -- high unconj bili, jaundice |
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Term
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Definition
| anemia of chronic disease |
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Term
| viruses causing aplastic anemia |
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Definition
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Term
| hemolytic anemia in a newborn |
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Definition
| pyruvate kinase def -- can't make enough ATP to maintain RBC structure --> removed by spleen!! |
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Term
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Definition
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Term
| paroxysmal nocturnal hemoglobinuria |
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Definition
| impaired GPI synthesis --> can't hold CD59, CD55 |
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Term
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Definition
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Term
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Definition
warm -- IgG, auto-immune stuff (SLE, CLL), drugs
cold -- IgM, infection (acute) or neoplasm (chronic, CLL) |
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Term
| direct vs. indirect Coombs |
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Definition
direct -- detect Ig on RBC
indirect -- detect Ig in serum |
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Term
| hemochromatosis vs. sideroblastic anemia |
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Definition
BOTH: high iron
hemochromatosis -- high ferritin, low TIBC
sideroblastic anemia -- nml ferritin, nml to low TIBC |
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Term
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Definition
| tests fibrinogen/thrombin |
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Term
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Definition
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Term
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Definition
decreased Gp1b
low platelet count (giant platelets -- stick to each other, but not to collagen!!, too big to count!!) |
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Term
| Glanzmann's thrombasthenia |
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Definition
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Term
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Definition
anti-GpIIb/IIIa antibodies
low platelet count (removed by spleen) |
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Term
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Definition
ADAMTS13 (vWF metalloprotease) def.
low platelet count b/c aggregate (lots of vWF) and used up (thrombosis) |
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Term
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Definition
STOP Making New Thrombi
Sepsis
Trauma
Obstetric
Pancreatitis
Malignancy
Nephrotic syndrome
Transfusion |
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Term
| most common cause of hypercoagulability |
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Definition
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Term
| protein C activated by... |
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Definition
| thrombomodulin (from endothelial cells) |
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Term
| pro-aggreggation and anti-aggreggation prostaglandings |
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Definition
pro - TxA2 from platelets
anti - PGI2 (prostacyclin) from endothelial cells |
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Term
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Definition
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Term
| prothrombin gene mutation |
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Definition
| increased plasma prothrombin levels --> hypercoag |
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Term
| increased risk of arterial AND venous thrombosis |
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Definition
| homocystienuria, anti-phospholipid antibody syndrome |
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Term
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Definition
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Term
| what's in cryoprecipitate |
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Definition
| fibrinogen, VIII, XIII, vWF |
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Term
| electrolyte changes with blood transfusion |
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Definition
hypocalcemia -- citrate is calcium chelator
hyperkalemia -- lysed RBCs |
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Term
| leukemoid reaction vs. CLL |
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Definition
CLL -- low leukocyte alk phos; monoclonal
leukemoid reaction -- high leukocyte alk phos; polyclonal |
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Term
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Definition
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Term
Hodgkin's vs. non-Hodgkins
-- who gets it
-- where/spread
-- B signs |
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Definition
Hodgkin's -- EBV, bimodal; localized with continguous spread, lots of B symptoms
non-Hodgkins -- HIV/immunosuppression, mutiple with extranodal and noncontinguous spread, fever B symptoms |
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Term
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Definition
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Term
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Definition
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Term
| Hodgkin's lymphoma types, prognosis, most common? |
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Definition
nodular sclerosing -- excellent prog; most common
lymphocyte-predominant -- excellent prog
lymphocyte-rich -- intermediate prog
mixed cellularity -- intermediate prog
lymphocyte depleted -- poor prog
** Reed-Sternberg cells bad
** lymphocytes good! |
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Term
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Definition
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Term
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Definition
Endemic/African -- jaws
Sporadic/American -- pelvis/abd
"starry-sky", proliferation rate (Ki-67 fraction) ~100%!! |
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Term
| non-Hodgkin's B-cell lymphoma types |
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Definition
Burkitt's -- t(8;14), c-myc
Diffuse large B-cell
Mantle cell -- t(11;14), cyclin d1
Follicular -- t(14;18), bcl2
Marginal/MALToma -- t(11;18) |
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Term
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Definition
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Term
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Definition
adult t-cell lymphoma -- HTLV-1
mycosis fungoides/Sezary syndrome -- CD4+ |
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Term
| multiple myeloma vs. Waldenstrom's macroglobulinemia vs. MGUS |
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Definition
MM -- IgG or IgA
Waldenstroms -- IgM (--> hyperviscosity like retinal vasc dilation with blindness!); no lytic lesions
MGUS -- MM with no symptoms |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| most common malignancy in kids |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
t(15;17)
Auer rods -- peroxidase +
all-trans retinoic acid
DIC |
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Term
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Definition
t(9;22), bcr-able
low leukocyte alkaline phosphatase
blast crisis |
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Term
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Definition
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Term
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Definition
| Langerhans cell histiocytosis, T cells |
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Term
| polycythemia vera, essential thrombocytosis |
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Definition
| increased sensitivity to growth factors |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
activates GpIb
von Willibrand's disease -- poor platement adhesion in presence of retocin |
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Term
| why reticulocytes are blue |
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Definition
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Term
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Definition
thymoma
lymphocytic leukemias
parvovirus |
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