Term
| Side effect of hydroxychloroquinine (Plaquenil) |
|
Definition
| macular damage , avoid if retinal disease / do regular checkups |
|
|
Term
| Hydroxychloroquinine (Plaquenil), Azulfidine, Gold (oral) |
|
Definition
|
|
Term
| Gold (IM), Leflunomide (Arava) , Methotrexate, Azathioprine (Imuran) |
|
Definition
| Potential toxicity: moderate |
|
|
Term
| Cyclosporine, D-Penicillamine |
|
Definition
|
|
Term
| Avoid if TNF inhibitors if this DMARD is used |
|
Definition
|
|
Term
| In addition to myelosupression and GI side effects also has RASH, PROTEINURIA |
|
Definition
|
|
Term
| In addition to hepatotoxicity, myelosupression, and preg. problems this DMARD has unique property of PULMONARY side effects |
|
Definition
|
|
Term
| This DMARD should be avoided w/ any sulfa allergies (I think maybe its sulfa drugs) either way avoid...sulfa something |
|
Definition
|
|
Term
| hepatotoxicity, GI, pregnancy side effects |
|
Definition
|
|
Term
| Myelosupression, hepatic, LYMPHOPROLIFERATIVE |
|
Definition
|
|
Term
| most toxic, probably dont use at all |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Humira (Adalimumab) what is it |
|
Definition
|
|
Term
| Simponi (Golimumab)what is it |
|
Definition
|
|
Term
| Cimiza (Certolizumab) what is it |
|
Definition
|
|
Term
| Which biological DMARD is prob safest for pregnancy |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Kineret and Actimra function as |
|
Definition
|
|
Term
| Rituximab and Abatacept are |
|
Definition
|
|
Term
|
Definition
| B-cell inhibitor (anti-CD20) |
|
|
Term
|
Definition
| T-cell inhibitor (CTLA-41g Soluble fusion protein) |
|
|
Term
| Lymphoma is a contraindication to TNF antagonists except for |
|
Definition
| Rituxan (anti CD20 B cell inhibitor) |
|
|
Term
Abatacept (Orencia) - T cell inhibitor CTLA-41g soluble fusion protein AND
Enteracept (enbrel) - souble TNF receptor
are probably best for |
|
Definition
| treating pt w/ latent TB infection |
|
|
Term
| Must be taken daily biological DMARD |
|
Definition
| Actimra (Tocilizumab) Ab to Il-6 receptor |
|
|
Term
| Can be taken every two weeks biological DMARD |
|
Definition
| Adalimumab (Humira) - IgG1 mAb to TNF |
|
|
Term
| Includes protein kinase inhibitors, JAK kinase inhibitors |
|
Definition
|
|
Term
| Hepatitis B is a contradindication although its unclear effect w/ many you DEFINATLEY AVOID |
|
Definition
| Ritiximab (Rituxan) B - cell inhibitor anti CD20 |
|
|
Term
| multiple sclerosis, optic neuritis is a contraindication to what type of DMARD |
|
Definition
|
|
Term
| If infection is a risk consider this biologic DMARD |
|
Definition
| Abatacept (Orencia) - T cell inhibitor CTLA41g soluble fusion protein |
|
|
Term
| As far as TNFis go for biological DMARDs there is best evidence of this one being effective |
|
Definition
|
|
Term
| If seropositive use ___1__ if rapid progression avoid ____2__ |
|
Definition
Rituximab - B cell inhibitor
Abatacept T cell inhibior |
|
|
Term
| This DMARD is associated w/ increased toxicity for Adult Onset Still's Disease pts |
|
Definition
|
|
Term
| good treatments for Adult onset Still's |
|
Definition
| Plaquenil + Kineret (Anakira) (IL-1 receptor inhibition) |
|
|
Term
| If abnormal LFTs (liver function tests) then might not want to use these w/ Adult onset stills |
|
Definition
| NSAIDS (watch closely, Methotrexate |
|
|
Term
G-CSF (granulocyte colony stimulating factor) is primary treatment if insufficent response try
lithium, pulse methylprednisone, splenectomy |
|
Definition
| Felty's syndrome treatment |
|
|
Term
| Req. contraception (prob 2 forms) during and 3-6 months after |
|
Definition
|
|
Term
| Req. contraception (prob 2 forms) during and 2 years after |
|
Definition
|
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