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quiz numero dos
quiz numero dos
63
Psychology
Post-Graduate
03/23/2011

Additional Psychology Flashcards

 


 

Cards

Term
Antidepressent Side Effects
Definition
Onset within a few days of ABRUPT discontinuation of SSRI
Term
Worst medicines for discontinuation side effects
Definition
Paxil and Effexor
Term
Side Effects of Discontinuation
Definition

Diziness

Vertigo

Nausea

Vomiting

Diarrhea

Fatigue

Myualgia

chills

Paresthesia

insomnia

vivid dreams

Term
How long until withdrawal side effects to resolve?
Definition
3 to 21 days
Term

What does Remeron (mirtazapine) block?

Definition
  • The reuptake of NE and Serotonin (5HT1): Antidepressant Effects
  • Blocks the 5-HT2 and 5-HT3 Receptor Sites
Term

By Blocking the reuptake of 5HT1 Remeron decreases

 

Definition
Antidepressant Effects
Term

Remeron Blocks the 5-HT2 and 5-HT3 Receptor Sites resulting in:

Definition
  • Fewer Activatoin Side Effects
  • Fewer Sexual Side Effects
  • Less Nausea, Headaches
  • Can be sedating
  • Increase appetite and weight gain
Term

What are some negative effects of Children/Adolexcents & Antidepressants

Definition

Increase chance of becoming suicidal

  • 2 times as likely to develop suicidal thoughts.
  • FDA has a black box warning
  • Benefit to risk ratios unfavorable
    • Paxil
    • Zoloft
    • Effexor
Term
Monoamine Oxidase Inhibitors 
Definition

Antidipressant Effects throught the inhibition of MAO

  • MAOI's are used on a limited basis because of their interaction with certain medications and foods containing Tyramine
Term
Medications to Avoid when using Monoamine Oxidase Inhibitors (MAOI's)
Definition
Sympathomimetic Medications (Nasal Sprays, Asthma Sprays, Cold Medications (daytime stuff)
Term
Why are foods avoided with MOAIs?
Definition

It increases the release of NE and slows down the enzymes that destroy it overloding the synops.

 

Term
Reversible MAOI's
Definition
Bond with the enzyme temporarily.  They slow it down and once the NE is reduced it releases the enzymes.
Term
If bipolar goes untreated
Definition

9 years of their life

14 years of funtional activity

12 years of normal health

Term
Effects of recurrence of Bi-Polar
Definition
  • Marked increase of suicide
  • High rate of divorce
  • high rate of job loss
  • Increased likelihood of substance abuse (55%+)
Term
Four Bipolar Specifiers
Definition
  • Without full inter-episodic recovery (between cycles)
  • With Full inter-episodic recovery
Term
First form of Treatment for Bipolar
Definition
Lithium
Term
Actions of Lithium
Definition
  • Lithium, lightest of the alkali metals, similar to sodium
  • Has no effect on the brain except in relation to mania
  • Action is not completely understood, may alter neuronal sodium transport
  • Effective in 60-80 percent of acute hypomanic and manic episodes
Term
Toxic Effects of Lithium
Definition
  • 1.5 to 2.0 mEq/L blood levels
  • Nausea/vomiting
  • Diarrhea
  • Abdominal pain
  • Mild Tremor
  • Lethargy
  • Impaired concentration
Term
Tegretol is more effective as a:
Definition
Slide 19 has the info
Term
Depakote
Definition
Is effective in the treatment of acute mania, mixed states, schizo-affective disorder and rapid-cycling
Term
Depakote increases
Definition
Increases GABA
Term
Depakote has a faster onset if
Definition
loaded intervenously.
Term
Neurontin
Definition
(gabapentin)
Term
Lamictal
Definition
(lamotrigine)
Term
Lamictal can develop
Definition
a rash that could be fatal.  Steven's Johnson syndrome
Term
Topamax can
Definition
reduce weight
Term
Symbiax
Definition
is a combonation of Zyprexa and Prozac
Term
Different Serotonin Receptors

5-HT- sub 1
Definition

  Antidepressant Effects - promote blocking of re-uptake

 

 

 

Term
Different Serotonin Receptors

5-HT-sub 2
Definition

 - Causes activation Side Effects

Aggitation

Restlessness

Sexual Disfunction

Term
Different Serotonin Receptors

5-HT-sub 3
Definition

Side Effects -

 

Nausea

Headaches

Vomiting

Term
Melancholic Features and Atypical tend to respond to
Definition
 antidepressants with dual action (Effexor, Remeron, Cymbalta, Pristiq).
Term
Psychotic features usually require
Definition
 the augmentation of an antipsychotic or ECT
Term
Refractory Depression (TRD) usually requires
Definition
a combination of antidepressants and other psychotropic medications.
Term
Child/adolesc and antidepressants Benefit to risk ratio favorable
Definition

 

 

prozac(fluoxitine)

Remeron(mirtazapine)

Term
Child/adolesc and antidepressants benefit to risk ratios unfavorable (increase suicidal tendencies and black box warning)
Definition

paroxetine - Paxil

setraline - Zoloft

venlafaxine - Effexor

 

Term
Irreversible MAOI
Definition

bonds with the enzyme and don't let it go

 

enzyme is screwed

 

 

Term
after stopping one Irreversible MAOI, how long is needed before giving a new Irreversible MAOI
Definition
Requires a two week wash up before new drugs can be given
Term
name 2 Selective Norepinephrine reuptake inhibitor (SNRI)
Definition

Edronax/Vestra (reboxetine)

stimulant


ADHD - Strattera (atomoxitine)

Term
Bipolar Spectrum
Definition

Cyclothymia - weakest

 

Bipolar II

 

Bipolar I - worst

Term
Bipolar Disorder Recurrence
Definition

 

 

- patients with a single manic episode have 70%

 

- likelihood of just one manic episode is a full lifetime is near 0%

Term
Bipolar Disorder
Definition

DSM characteristics

 

Mania - 3 of 7 bullets

Term
Bipolar Specifiers
Definition

With seasonal patterns

- last two years, onset of depressive episode only, fall-winter

constant cycle change a particular time of the year

Term
Bipolar Specifiers
Definition

with rapid cycling

 

- not ups and downs the same day

 

- specifier not a category

 

- 4 episodes in one year; mixed, manic, depressive

Term
Actions of Lithium
Definition

- Absorbed very differently by people 

 

- It has a narrow therapuetic window

 

- It can be toxic

 

- Regular blood tests important

Term
Actions of Lithium
Definition

- Because lithium resembles table salt,

when a patient lowers salt intake,

lithium blood levels can rise.

 

- Also being dehydrated

Term
Tegretol
Definition
 (carbamazepine)
Term
Anticonvulsants
Definition
Slow down neural transmissions
Term
Tegretol
Definition

Adverse effects -

 

- Leukopenia - reduction of white blood cells

- potentially teratogenic (can effect fetus)

 

Term
Depakote
Definition
(valproic acid)
Term
Neurontin
Definition

- Does not alter the kinetics of lithium

Term
Lamictal
Definition
Term
Topamax
Definition
(topiramate)
Term
Topamax
Definition

- many lose weight

- appears to work good

- success with schizoaffective as well

 

If over weight, may be good drug to go with

Term
Serotonin Syndrome
Definition

Diarrhea

Hypertension

Tachycardia (racing heart)

Ataxia ( muscle in coordination)

Increased reflexes

Myoclonus (muscle jerking)

 

Term
Serotonin Syndrome
Definition

Disoriented

Confusion

Hypomania

Agitation/restlessness

Fever

Chills

Sweating

 

 

Term
Antidepressants with dual action
Definition
Effexor, Remeron, Cymbalta
Term
3 types of Irreversible MOAIs
Definition

 

Nardil (phenelzine)
Parnate (tranylcypromine)
Marplan (isocarboxazid)
Term
–Nardil
Definition
(phenelzine)
Term
–Parnate
Definition
(tranylcypromine)
Term
–Marplan
Definition
(isocarboxazid)
Term
If a person’s onset is at age 25, it is estimated that he/she (untreated) will lose:
Definition
Nine years of their life
14 years of functional activity
12 years of normal health
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