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Quiz 1
Parasympathomimetics, Acetylcholinesterase inhibitors, and anticholinergics
52
Chemistry
Graduate
09/05/2011
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Term
acetylcholine
 Definition
parasympathomimetic-Direct agonist
Term
methacholine
 Definition
parasympathomimetic-direct agonist
Term
carbachol
 Definition
parasympathomimetic-direct agonist
Term
pilocarpine
 Definition
parasympathomimetic-direct agonist
Term
bethanechol
 Definition
parasympathomimetic-direct agonist
Term
physostigmine
 Definition
parasympathomimetic-acetylcholinesterase inhibitor
Term
neostigmine
 Definition
parasympathomimetic-acetylcholinesterase inhibitor
Term
pyridostigmine
 Definition
parasympathomimetic-acetylcholinesterase inhibitor
Term
rivastigmine
 Definition
parasympathomimetic-acetylcholinesterase inhibitor
Term
tacrine
 Definition
parasympathomimetic-acetylcholinesterase inhibitor
Term
donepazil
 Definition
parasympathomimetic-acetylcholinesterase inhibitor
Term
DFP
 Definition
parasympathomimetic-acetylcholinesterase inhibitor-organophosphate
Term
echothiophate
 Definition
parasympathomimetic-acetylcholinesterase-organophosphate
Term
Sarin
 Definition
parasympathomimetic-acetylcholinesterase inhibitor-organophosphate-nerve gas
Term
soman
 Definition
parasympathomimetic-acetylcholinesterase inhibitor-organophosphate-nerve gas
Term
tabun
 Definition
parasympathomimetic-acetylcholinesterase inhibitor-organophosphate-nerve gas
Term
dichlorphenathon
 Definition
parasympathomimetic-acetylcholinesterase inhibitor-organophosphate-nerve gas
Term
pralidoxime (2-PAM)
 Definition
antidote to organophosphate poisoning
Term
atropine
 Definition
anticholinergic-parasympatholytic/antimuscarinic
Term
scopolamine
 Definition
anticholinergic-parasympatholytic/antimuscarinic
Term
ipratropium
 Definition
anticholinergic-parasympatholytic/antimuscarinic
Term
glycopyrrolate
 Definition
anticholinergic-parasympatholytic/antimuscarinic
Term
propantheline
 Definition
anticholinergic-parasympatholytic/antimuscarinic
Term
procyclidine
 Definition
anticholinergic-parasympatholytic/antimuscarinic
Term
darifenacen
 Definition
anticholinergic-parasympatholytic/antimuscarinic-OAB
Term
d-tubocuranine
 Definition
nicotinic antagonist-neuromuscular blocker
Term
succinylcholine
 Definition
nicotinic antagonist-neuromuscular blocker
Term
atracurium
 Definition
nicotinic antagonist-neuromuscular blocker
Term
rocuronium
 Definition
nicotinic antagonist-neuromuscular blocker
Term
fesoterodine
 Definition
anticholinergic-antimuscarinic-OAB
Term
tolterodine
 Definition
anticholinergic-antimuscarinic-OAB
Term
oxybutynin
 Definition
anticholinergic-antimuscarinic-OAB
Term
solifenacin
 Definition
anticholinergic-antimuscarinic-OAB
Term
trospium
 Definition
anticholinergic-antimuscarinic-OAB
Term
ester/carbamate + pos. charged 3/4 amine
 Definition
parasympathomimetic-direct agonist and acetylcholinesterase inhibitors
Term
Has P in it
 Definition
organophosphate (inc nerve gases)-acetylcholinesterase inhibitors>parasympathomimetics
Term
VX
 Definition
parasympathomimetic-acetylcholinesterase inhibitor-organophosphate-nerve gas
Term
2 lipophilic rings + H-bonding group + short chain to a pos charged N
 Definition
antimuscarinic>anticholinergic (inc OAB)
Term
2 pos. charges separated by 10-12 Ang
 Definition
nicotinic antagonist (neuromuscular blocker)
Term
usually used for glaucoma (4)
 Definition

carbachol

physostigmmine (carbamate)> acetylcholinesterase inhibitor DFP > acetylcholinesterase inhibitor/organophosphate echothiophate> topical, organophosphate

 
Term
treats myasthenia gravis
 Definition
neostigmine and pyrrdiostigmine
Term
Treats alzheimers (3)
 Definition
rivastigmine (early symptoms)-has carbamate
tacrine (reverse inhibitor of acetylcholinesterase)
donepazil
Term
causes pupillary dilation, antimuscarinic, antidote to organophosphate poisoning
 Definition
atropine
Term
pupillary dilation, motion sickness drug
 Definition
scopolamine
Term
bronchodilation-treats asthma
 Definition
ipratropium
Term
used in surgery
 Definition
neuromuscular blockers: atracurium, rocuronium, succinylcholine and d-tubocurarine
Term
used in research only
 Definition
R isomer of methacholine
Term
reactivator of acetylcholinesterase
 Definition
2-PAM
Term
natural product, acts as muscarinic agonist, to treat glaucoma
 Definition
pilocarpine
Term
most rapidly hydrolyzed by AchE
 Definition
acetylcholine
Term
used to induce urination from paralyzed bladders
 Definition
bethanechol
Term
what is used to induce urination from paralyzed bladders?
 Definition
bethanechol
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