Term
|
Definition
Inhibits synshesis of prostaglandins and thomboxane in circulating platelets.
Helps to prevent platelets from aggregating to exposed collagen fibres at sites of vascular injury. |
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Term
| Acetylsalicylic Acid ( Aspirin) - Presentation |
|
Definition
|
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Term
|
Definition
| Converted to salicylic acid in many tissues, but primarily in GI mucosa and liver and excreted by the kidneys. |
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Term
|
Definition
| Suspected AMI or ischemia |
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Term
| Aspirin - Contraindications |
|
Definition
Known severe adverse reaction to aspirin or NSAIDS (Non steroidal anti inflammatory drugs)
Bleeding Disorders
Current GI bleeding or peptic ulcers
Children less than 12 years |
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Term
|
Definition
Possible aortic aneurysm or othe condition requiring surgery
Pregnancy
History of peptic ulcers or GI bleeding
Concomitant anti-coagulant therapy ( Not Clopidogrel) |
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Term
|
Definition
Epigastric Pain / Discomfort
Nausea / Vomiting
Gastritis
GI Bleeding
Tinnitis
Bronchoconstriction in some asthmatics |
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Term
| Aspirin - Route of administration |
|
Definition
| Oral - with a glass of water followed where possible |
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Term
| Aspirin - Times and effect |
|
Definition
10 minutes dependant on stomach contents
Anti-platelet action - lasts for several days |
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Term
|
Definition
| Adult - Oral 300Mg. Chewed and washed with glass of water. |
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Term
| Why is aspirin contraindicated in children under 12. |
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Definition
| A rare often fatal disorder called reyes syndrome. Can cause brain swelling, fatty degeneration of the liver causing hepatitis. Presents with intractable vomiting follwed by progressive encephalopathy. |
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Term
| Why is aspirin a precaution for pregnancy. |
|
Definition
When given late in pregnancy it may cause premature closure of the fetal ductus arterious, prolong labour and delay birth due inhibiting prostaglandin synthesis.
It can increase bleeding time in the newborn and the mother due to the antiplatelet effects. |
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Term
| Why is warfarin a precaution in the use of aspirin. |
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Definition
| Warfarin is normally 98% bound to plasma protein albumin leaving 2% active with plasma. Aspirin has high affinity for albumin and displaces warfarin increasing warfarin available for effect. |
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Term
| Why is asthma a precaution for aspirin. |
|
Definition
| Pts may have 'aspirin intolerant asthma', a hypersensitive syndrome to aspirin causing bronchoconstriction, chronic rhinosinusitis. |
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Term
| Why is aspirin administered by chewing the tablet. |
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Definition
| Chewing increases the surface area and enhances buccal mucosa absorption. |
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