Term
| Mechanism of Action of Corticosteroids |
|
Definition
Intracellularly Binds HSP90-> Nucleus->GRE
Block Neutrophil Migration
Decrease Prostaglandin Synthesis
Block Cytokine release-> Decrease Ig
Metabolic Effects |
|
|
Term
| Metabolic Effects of Corticosteroids |
|
Definition
Carb: Increase Gluconeogenesis from AA Protein: Increase Proteineolysis-> AA
Lipid: Increase Liposis-> FAs-> Abdomen Electrolytes: Increase Na, Cl, decrease K-> Hypokalemia and HPTN |
|
|
Term
| Administration Methods of Corticosteroids |
|
Definition
| IM, IV, Oral, Intraarticular, Topical Prednisone is only oral administration |
|
|
Term
| Pharmacokinetics of Corticosteroids |
|
Definition
CBG 90%, Albumin (some) 10% free transport
Liver and some Kidney Redution, Hydroxylation, Conjugation |
|
|
Term
| Side Effects of Corticosteroid Use |
|
Definition
Cataracts, Peptic Ulcer, Pychosis,
Osteoporosis, Myopathy, Infection,
HPTN, Hypokalemia |
|
|
Term
| Contraindications to Corticosteroids Use |
|
Definition
Peptic Acid Disease
Psych Problems
Chronic Infection (TB)
Osteoporosis |
|
|
Term
How should corticosteroid use be terminated?
What are the symptoms of improper termination? |
|
Definition
Gradual decrease in dose to prevent adrenal insufficiency symptoms
Abrupt: Adrenal insufficiency(glucose crisis)
Myalgia
Arthralgia
Fever/Malais |
|
|
Term
| Therapeudic uses for corticosteroids |
|
Definition
| Allegies, Arthritis, Immunosuppression, Dermatological, Adrenal Insufficiency/Congenital Hyperplasia |
|
|
Term
What are the uses of Spironolactone?
Adverse Effects of Spironolactone |
|
Definition
Use:
CHF
Primary/Secondary Hyperaldosterone
Adverse
Hirsutism
Gynecomastia |
|
|
Term
What are the commons steroids used for: Degenerative Joint Disease?
Asthma?
Hypoaldosterone? |
|
Definition
DJD
Triamcinolone
Methylprednisone
Asthma
Dexamethasone
Beclomethasone
Hypoaldosterone
Fludrocortosone |
|
|
