Term
| Classifications of Coal Worker's Pneumoconiosis |
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Definition
Anthrocosis: carbon in lymph, macs, CT
Simple CWP: Mac Accumulation in Upper Lung
Complicated CWP:Large Black scars lung Dysfunction |
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Term
|
Definition
Small palpable nodules-> Hard Collagenous Scar
With TB/ischemia->softening and Calcification
Honeycombing: Uneven compressing of parenchyma |
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Term
|
Definition
| Mac's ingest->Cellular toxicity-> Cytokines->Fibrosis |
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|
Term
Morphological types of Asbestos
Which is more Pathogenic |
|
Definition
Serpentine: Curly/flexble
Amphibole:Straight/Brittle-More Pathogenic |
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Term
| Manifestations of Asbestos Exposure |
|
Definition
Pleural Plaques
Pleural Effusions
Parenchymal Interstitial Fibrosis
Mesothelioma
Brochogenic Carcinoma
Laryngeal/Extra Pulmonary Neoplasms |
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Term
| Where do asbestos pleural plaques arise anatomically in the lung |
|
Definition
| Mostly lower lobes and subpleural areas anteriorly and/or posterolaterally and progess superiorly |
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Term
| What is the composition of asbestos pleural plaques |
|
Definition
| collagen and calcification |
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Term
| Histology of an Asbestos Body |
|
Definition
| Fusiform Beaded rod with Fe-containing protein coat |
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Term
| Where would a patient most likely have been exposed to Beryllium |
|
Definition
| Aerospace or Nuclear Industry |
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|
Term
| What is the histology of chronic berylium exposure |
|
Definition
| Non-caseating Granulomas in Lung, Hilar nodes, less commonly(Spleen, liver) |
|
|
Term
| What demographics are most likely and least likely to develop sarcoidosis |
|
Definition
Most: African American, Women
Least: Chinese, Southeast Asian |
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Term
|
Definition
Non-caseating granulomas-> hylanize
Schauman's Bodies- Concentric Ca and Protein
Asteroid bodies- Stellate inclusions |
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Term
| Histologic progression of Idiopathic Pulmonary Fibrosis |
|
Definition
| Injury->Alveolitis->Type II Hyperplasia-> Fibroblast form Fibrosis and Exudate-> Honeycomb |
|
|
Term
| What are the different manifestations of Idiopathic Pulmonary Fibrosis |
|
Definition
Usual: Temporal Heterogeneity (Normal/Abnormal Alternations)
Desquamative Interstitial Pneumonia: diffuse macrophage accumulation(Lipid + PAS granules)
Acute Intersitial Pneumonia: Rapid development with respiratory failure, with diffuse interstitial fibroblastic Proliferation |
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Term
| Mortality and Treatement of each IPF manifestation |
|
Definition
Usual: Poor response to steroids >60% Mortality
DIP: Steroid clears lungs, 27% Mortality
AIP: No response, >90% Mortality |
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Term
| Causes of Farmer's, Pigeon breeder's, Humidifer's Lung |
|
Definition
Farmer: Thermophillic actinomyces
Pigeon: Protein from feathers/excreta
Humidifier: Thermophillic bacteria |
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Term
| Clinical Presentation of Hypersensitivity Pneumonitis in terms of timing of symptoms, CXR, PFT's |
|
Definition
4-6 Post-exposure symptoms
CXR: Nodular infiltrate
PFTs: Restrictive disease |
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Term
| Histology of Hypersensitivity Pneumonitis |
|
Definition
Interstitial Pneumonitis
Interstial fibrosis
Obliterative Bronchiolitis
Granulomas |
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|
Term
| What lobes of the lung are more likely to involve CWP, Silicosis, Asbestosis |
|
Definition
Lower lobes: Asbestos
Upper Lobes: CWP, Silicosis |
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