Term
|
Definition
| Diptheriods, H. influenzae, Moraxella, Coag (-) Staph, Staph aureus, Pneumococci |
|
|
Term
| Most common causes of Pharyngitis |
|
Definition
| Adenovirus, Rhinovirus, Group A Strep |
|
|
Term
| Most common cause of Otitis Media |
|
Definition
| S. pneumoniae, Non-typable H. influenzae, Moraxella |
|
|
Term
| Presentation of Otitis Media |
|
Definition
| Inflamed Typanic membrane with purulent fluid behind |
|
|
Term
| Presentation of Pharyngitis |
|
Definition
| Pain while swallowing with an inflamed pharynx |
|
|
Term
|
Definition
| Small Gram (-) coccibacillus, cocci, bacili |
|
|
Term
| Lab Diagnosis of Moraxella |
|
Definition
| Oxidase (+), Non-Carb Fermenter, Blood Agar culturable |
|
|
Term
| Diseases caused by Moraxella |
|
Definition
Otitis Media, Sinitis
Brochisis, Pneumonia, Conjunctivitis in Elderly or Compromised |
|
|
Term
|
Definition
| Non-Beta Lactam Antibiotics |
|
|
Term
| Morphology of Haemophillus influenzae |
|
Definition
| Small Pleomorphic Gram (-) Bacillococci, Bacilli |
|
|
Term
| Lab Growth of H. influenzae |
|
Definition
| Satellite Colonies on Blood Agar Cocolate agar with Factor V and X (NAD and Hematin Respectively) |
|
|
Term
| Virulence factors for H. influenzae |
|
Definition
| Capsule, IgA Protease, Endotoxin, Membrane adhesive proteins |
|
|
Term
| Diseases causes by H. influenzae |
|
Definition
| Otitis Media, Epiglotitus, Pneumonia Meningitis, Arthritis, Cellulitis |
|
|
Term
| Lab Diagnosis of H. influenzae |
|
Definition
PRP Latex Agglutination
Site swab cultured on Chocolate agar |
|
|
Term
| Immunity to H. influenzae |
|
Definition
|
|
Term
| Non-Typeable H. influenzae diseases |
|
Definition
| Sinitus, Otitis Media, Pneumonia, Bronchitis |
|
|
Term
| What is H. influenzae Type B Antigen |
|
Definition
| Polyribose-Ribitol Phosphate |
|
|
Term
| Haemophillus influenzae Treatment |
|
Definition
Ampicillin first is sensitive, then Cephalosporins
35% are B-Lactam and AMP resistant |
|
|
Term
| Epidemiology of H. influenzae |
|
Definition
Nontypable: 60-90% Normal flora
Typable: 5-0.5% Carriers |
|
|
Term
| Prevention of H. influenzae |
|
Definition
PRP conjugated to CRM197 Diptheria Protein
immunization at 2,4,6 11-15 mths, 4-6 yrs, 11-18 yrs |
|
|
Term
| Morphology of Streptococcus pyogenes |
|
Definition
| Gram(+) Cocci in Chains, Catalase(-), B-hemolytic, Group A Antigen, Bacitracin Sensitive |
|
|
Term
| Epidemiology of Group A Strep |
|
Definition
| 30% of Anterior Nasals, <10yrs, Winter |
|
|
Term
| Strep pyogenes Transmission |
|
Definition
|
|
Term
| Virulence Factors for Streptococcus Pyogenes and Role |
|
Definition
Streptolysin O and S
M-Protein- binds keratin
Streptokinase, Streptodornase, Hyluronidase
Capsule with Hyluronic Acid
SPE A,B,C- Delayed Hypersensitivity, Superantigen-> IL-1, TNF-alpha |
|
|
Term
| Primary Infections Presentation of Strep Pyogenes |
|
Definition
| White Exudate in Pharynx with enlarged tonsils and anterior cervical lymph nodes |
|
|
Term
| Presentation of Post-Strep Rheumatic fever |
|
Definition
| Type II Hypersensitivity: Carditis, Chorea, Erythema Marginatum, Subcutaneous Nodules, Polyarthritis, Fever, high ESD/CRP, Prolonged PR, Arthia |
|
|
Term
| Presentation of Post-Strep Glomerulonephritis |
|
Definition
| Type III Hypersensitivity: Hematuria, Hypertension, Facial Edema |
|
|
Term
| Acquirement of SPE A and C |
|
Definition
|
|
Term
| Lab Diagnosis of Strep pyogenes |
|
Definition
Sreptozyme
Gram(+), B-hemolytic, Group A, Catalase(-) Bacitracin Sensitive, CAMP(-) |
|
|
Term
| Mechanism of Immunity to Strep pyogenes |
|
Definition
|
|
Term
| Treatment for Strep pyogenes |
|
Definition
| Pencillin or Erythomycin if allegic to Penicillin |
|
|
Term
| Symptoms of Scarlet Fever |
|
Definition
| Sandpaper Rash, Strawberry Tongue |
|
|
Term
|
Definition
|
|
Term
| Distinguishing Group A from group B strep |
|
Definition
| Bacitracin Sensitive is A |
|
|
Term
| How are Otitis Media Infections made |
|
Definition
|
|
Term
| What Strep pyogenes sequelle can be prevented with antibiotics |
|
Definition
|
|
Term
| Morphology of Bordetella pertussis |
|
Definition
| Gram (-) Coccobacillus, Strict Aerobe |
|
|
Term
|
Definition
| Charcoal or Bordet-Gengou Agar |
|
|
Term
| Virulence Factors of B. pertussis and Mechanism |
|
Definition
Pertussis Toxin-ADP-Ribosylation of Gs
Tracheal Endotoxn
Invasive Adenylate Cyclase Filamentinous Hemmaglutinin
Hemolysin, Dermonecrotic Heat-labile toxin |
|
|
Term
| Disease Stages of Pertussis and Timing |
|
Definition
Catarrheal: Rhinorrea, Sinitis (1-2 wks)
Paroxysmal Cough: Inspiratory Whoop from narrow glottis, Lymphocytosis (wks 2-3)
Convelescent: Symtom Fade (wks 3-4) |
|
|
Term
| Lab Diagnosis of Pertussis |
|
Definition
Culture
Immunoflorescence
PCR |
|
|
Term
|
Definition
| sIgA, but doesn't last a lifetime |
|
|
Term
| Empidemiology of Pertussis |
|
Definition
| Infants and Children, Only Humans |
|
|
Term
|
Definition
| Vaccine @ 2,4,6, 11-15 mths, 4-6 yrs, 11-18 yrs |
|
|
Term
| Hallmark of Pertussis Infection |
|
Definition
|
|
Term
| Hallmark of Pertussis Infection |
|
Definition
|
|
Term
| Morphology of Corynebacterium diptheriae |
|
Definition
Gram (+) rod, non-spore forming, aerobe
Chinese Letter, Palisading Arrangement, Metachromatic Granules in Methylene Blue |
|
|
Term
| Virulence Factors of Diptheriae |
|
Definition
| Diptheria Toxin-EF-2 ADP-Ribosylation |
|
|
Term
| Important points about diptheria toxin |
|
Definition
Beta phage carrying
DtxR represses gene if Fe is present |
|
|
Term
Presentation of a diptheria patient |
|
Definition
1)Pseudomembranous plaque that bleeds when scratched, Bull Neck, Systemic Effects
2)Skin ulceration with dirty gray base
3)Mild Pharyngitis if diptheriod |
|
|
Term
Lab Dx of Cornebacterium diptheria |
|
Definition
Clinical Diagnosis
Culture: K•Tellurite/Tinsdale Agar
Biochemical Testing
Tissue Culture |
|
|
Term
|
Definition
| Neutralizing Ig to Diptheria Toxin |
|
|
Term
|
Definition
Passive Equine Immunity against DT
Macrolides TX: Penicillin, Erythromycin |
|
|
Term
| Epidemiology of Pertussis |
|
Definition
|
|
Term
|
Definition
| Toxoid 2,4,6,11-15mths,4-6yrs,11-18yrs |
|
|
Term
| Why is Diptheria diagnosis reliant on clinical eveluation |
|
Definition
| Few organisms to culture and asymptomatic onset |
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