Term
| Which drugs are Preg Cat D? |
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Definition
| Phenytoin, Phenobarbital, Carbamazepine, VPA, Topiramate, and Clonazepam |
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Term
| Which drugs are Preg Cat C? |
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Definition
| Ethosuximide, Oxcarbazepine, Felbamate, Gabapentin, Lamotrigine, Levetiracetam, Zonisamide, Tiagabine, Pregabalin, LacosamideRufinamide, Vigabatrin |
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Term
| Which drug can cause hirsutism, gingival hyperplasia, coarsening of facial features, megaloblastic anemia, peripheral neuropathy, and osteopenia/osteoporosis? |
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Definition
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Term
| What is the target concentration for Phenytoin? |
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Definition
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Term
| CBC, EEG, LFT, MCV, serum albumin, and neuro function should all be monitored with which drug? |
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Definition
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Term
| Which drug is a potent inducer whose dosage must be decreased with cimetidine and chloramphenicol? |
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Definition
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Term
| With alcohol, Phenobarbital's metabolism is (decreased/increased/unaffected). |
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Definition
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Term
| Which drug may cause hyperactivity and delayed intellectual development in children, and may cause cognitive impairment in adults, rash, porphyria as well as sedation and depression? |
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Definition
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Term
| Phenobarbital, when started (can be given at desired dose/should start low and titrated upward). |
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Definition
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Term
| Which drug primarily causes GI disturbances, with significant NV? |
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Definition
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Term
| If near saturation, what drug's metabolism is inhibited? |
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Definition
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Term
| Which drug features a time dependent PK and interacts with clarithromycin, lamotrigine, verapamil, diltiazem, and induces warfarin, BZDs and oral contraceptives? |
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Definition
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Term
| CBC, LFT, lipids and urinalysis should be monitored in |
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Definition
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Term
| which drug has a BBW of aplastic anemia, agranulocytosis, and rash (SJS)? |
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Definition
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Term
| CBZ's target concentration is______ |
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Definition
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Term
| Which drug may cause Nystagmus, hepatotoxicity, hyponatremia, ataxia, tremor, gi upset, dizziness, ha and drowsiness? |
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Definition
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Term
| Which drug(s) has/have an active metabolite |
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Definition
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Term
| ______ increases phenytoin, lamotrigine, ethosuximide and phenobarbital levels? |
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Definition
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Term
| CBC, LFT and serum ammonia should be monitored with____ |
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Definition
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Term
| _____ has a BBW of hepatotoxicity, pancreatitis, teratogenicity |
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Definition
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Term
| VPA has a target concentration of_____ |
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Definition
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Term
| Which drug has AEs of alopecia, Polycystic Ovary Syndrome, Tremor, Encephalopathy, hyperammonemia, thrombocytopenia and weight gain? |
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Definition
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Term
| Which drug increases Phenytoin and phenobarb levels, decreases CBZ and lamotrigine levels, decreases oral contraceptive efficacy and interacts with VPA? |
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Definition
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Term
| Which drug causes nystagmus, diplopia, hyponatremia, rash, ataxia and somnolence? |
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Definition
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Term
| Which drug is reserved fo genuine refractory epilepsy? |
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Definition
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Term
| Which drug increases VPA, phenytoin and CBZ-epoxide? |
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Definition
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Term
| Which drug has AEs of anorexia, NV and insomnia? |
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Definition
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Term
| Which drug has BBWs of aplastic anemia and hepatotoxicity? |
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Definition
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Term
| Which drug has AEs of weight gain (with chronic use) somnolence and ataxia? |
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Definition
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Term
| This drug's bioavailability decreases as its dose increases? |
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Definition
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Term
| Gabapentin's dosing (does/does not) need to be altered with creatinine clearance |
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Definition
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Term
| Lamotrigine's t1/2 is (unaffected/affected) by renal failure. |
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Definition
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Term
| Which drug's t1/2 is increased by VPA, decreased by inducers, and will decrease VPA's Css by 25%? |
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Definition
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Term
| Which drug interacts with Oral contraceptives, CBZ and will alter VPA's levels? |
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Definition
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Term
| Which drug has AEs of diplopia, dizziness and ataxia? |
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Definition
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Term
| Which drug has BBWs of Rash (ie, SJS and Toxic Epidermal Necrosis) |
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Definition
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Term
| What is the dosing schedule for lamotrigine PTs on VPA? |
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Definition
first 1-2 wks: 25 mg every other day
wks 3-4: 25 mg/day
weeks 5 to maintenance: increase by 25-50 mg/d every 1 to 2 wks
Usual maintenance dose: 100-400 mg/d (in 1 or 2 divided doses); 100-200 mg/d with VPA alone |
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Term
| What is the dosing schedule for lamotrigine PTs on VPA? |
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Definition
first 1-2 wks: 25 mg every other day
wks 3-4: 25 mg/day
weeks 5 to maintenance: increase by 25-50 mg/d every 1 to 2 wks
Usual maintenance dose: 100-400 mg/d (in 1 or 2 divided doses); 100-200 mg/d with VPA alone |
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Term
| What is the dosing schedule for PTs on Lamotrigine and AEDs which ARE NOT CBZ, Phenytoin, Phenobarb, primidone or VPA? |
|
Definition
wks 1-2: 25mg/d
wks 3-4: 50 mg/d
wks 5+: incr 50 mg/d q1-2wks
maintenance: 225-375 mg/d (in 2 divided doses) |
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Term
| What is the lamotrigine dosing schedule for PTs on CBZ, Phenytoin, Phenobarb, primidone but NOT VPA? |
|
Definition
wks 1-2: 50 mg/d
wks 3-4: 100 mg/d (divided)
wks 5+: incr 100mg/d q1-2 wks
maintenance: 300-500 mg/d in 2 divided doses |
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Term
| Which drugs are renally eliminated and feature no interactions? |
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Definition
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Term
| Which drug(s) has/have AEs of asthenias, CNS effects, somnolence, and sedation? |
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Definition
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Term
| Which drugs are renally cleared? |
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Definition
| Gabapentin, Levetiracetam, Topiramate, and Pregabalin |
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Term
| Topiramate's concentration is decreased by 40% when interacting with______ |
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Definition
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Term
| Topiramate's concentration is reduced almost 50% when interacting with_____ |
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Definition
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Term
| Phenytoin's concentration is increased by 25% when interacting with ______ |
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Definition
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Term
| Topiramate's concentration is decreased by 14% when interacting with______ |
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Definition
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Term
| VPA's concentration is decreased 13% when interacting with_____ |
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Definition
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Term
| Which drug features AEs of word finding difficulties, renal calculi, paresthesia, metabolic acidosis, nephrolithiasis, weight loss, impaired concentration, and dizziness? |
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Definition
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Term
| Which drug is a sulfonamide? |
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Definition
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Term
| Zonisamide interacts with _____ |
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Definition
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Term
| Zonisamide's target level is _____ |
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Definition
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Term
| Which drug features AEs of oligohydrosis (in children) renal calculi, fatigue, somnolence and weight loss? |
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Definition
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Term
| If CrCl is under 70, Topiramate's dosing should be______ |
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Definition
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Term
| Which drug may increase status epilepticus in non epileptics? |
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Definition
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Term
| Which drug has AEs of asthenia, diarrhea, nervousness, dizziness and tremor? |
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Definition
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Term
| Which drug is an analog of GABA? |
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Definition
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Term
| Which drug has AEs of somnolence, dizziness and weight gain? |
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Definition
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Term
| Which drug is metabolized extensively by the liver? |
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Definition
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Term
| which drug has AEs of ataxia, behavioral changes (in children), tolerance, cognition/motor impairment and drowsiness? |
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Definition
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Term
| which drug should be tapered when discontinued? |
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Definition
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Term
| Which drug interacts with CBZ, phenytoin, and Phenobarb? |
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Definition
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Term
| What affect will Phenobarb have on Lacosamide? What must be adjusted? |
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Definition
| Lacosamide's levels are decreased; adjust lacosamide dosing |
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Term
| Which drug should not be used in severe hepatic impairment? |
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Definition
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Term
| which drug has AEs of Diplopia, HA, dizziness and nausea? |
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Definition
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Term
| Which drug increases Phenytoin levels, decreases OC efficacy, and if taken with VPA, doses of both drugs should be reduced? |
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Definition
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Term
| which drug causes somnolence, fatigue, gait and coordination problems, dizziness and ataxia? |
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Definition
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Term
| Vigabatrin decreases ____ levels |
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Definition
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Term
| Which drug has AEs of Vision loss, MRI abnormalities, edema, anemia, peripheral neuropathy, somnolence and weight gain? |
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Definition
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