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PT Test 10-30
Contraceptives
28
Pharmacology
Graduate
10/24/2009

Additional Pharmacology Flashcards

 


 

Cards

Term
When does a woman have the greatest chance of getting pregnant?
Definition

5 days before ovulation

 

5-45% chance of pregnancy during 6 day window

 

 

Term
What are the methods of natural planning?  When is this useful?
Definition

Calendar Method

 

Basal Body Temperature

 

Cervical Mucous Method

 

Symptothermal Method

 

More useful when PLANNING a pregnancy

Term
Name the different barrier options available
Definition

- Male/Female condoms

- Sponge

- Spermicide

- Diaphragm

- Cervical Cap

Term
What is the failure rate of male condoms?
Definition
15%
Term
What is different about the female condom?
Definition

- Polyurethane, not latex (Men could do either)

- 21% failure rate

- Can be inserted 8 hours prior

- Only use one condom or the other

Term
What is important regarding the sponge?
Definition

- Barrier

- Spermicide

- Absorbs semen

- 16-32% failure rate

- Toxic shock if left in

- Can be inserted up to 24 hours before and left in 6 hours after

Term
What are the forms of spermicides, the active ingredients, and failure rates?
Definition

- Foams, gels, suppositories (more gritty?)

- Failure rate 29%, more of a backup method

- Active ingredients are NOM NOM NOM.  Nonoxynol-9, Octoxynol-9, Menfegol

- Use higher concentrations with diaphragms and cervical caps

Term
What are the differences between diaphragms and cervical caps?
Definition

- Diaphragms have failure rate of 16%, latex filled with spermicide, professional fit

- Cerival cap has 16-32% failure, thimble shaped latex

- Cap can be left in longer than diaphragm, and don't need to reapply spermicide

Term
What are the differences between barrier vs. hormonal contraception?
Definition

- Only male/female condoms provide STD protection

- Hormonal contraceptives more efficacious

Term
What are the three phases of the menstrual cycle? How long does each last? 
Definition

- F, O, L

- Folicular (1-12 days), Ovulation (48 hours), Luteal (16-28 days)

Term
What are the effects of estrogen?  How about progesterone?
Definition

Estrogen:  Inhibits FSH and LH through neg. feedback.  Inhibits ovulation.  Accelerates ovum transport.  Inhibits ovum implant.  Potentiates Progestin

 

Progesterone:  Thickens mucous.  Inhibits LH, preventing ovulation.  Alters endometrium to stop implantation

Term
What is the differences between monophasic, biphasic, or triphasic therapy.  What happens if there is too little of each hormone?  What are the ACHES?
Definition

- Monophasic is the same dose all the time.  biphasic, or triphasic refer to either taking 1 or 2 different types of estrogen or progesterone doses, mimicing a natural cycle.  

- Excess of estrogen and progesterone cause n/v, bloating, tenderness or weight gain and acne, respectively

- Deficiency in each hormone leads to spotting and amenorrhea

- ACHES stand for what you should counsel on.  Abdominal pain, Chest pain, Headache, Eye problems, Severe leg pain.

Term
What are the advantages and disadvantages of oral contraceptives?
Definition

Advantages

- 8% efficacy

- Helps with acne

- reduce risk of endometrial and ovarian CA

- Helps dysmenorrhea

Disadvantages

- Increase BP

- Increase risk of stroke, MI, or TE disease

- Hormone side effects

Term
What are the absolute contraindications in regards to oral contraceptives?
Definition

- TE disease

- CVD

- Impaired liver function

- Estrogen dependent cancer

- Pregnancy

- Smokers greater than 35 years

- Abnormal genital bleeding

Term
What are some conditions in which you would use caution in regards to Oral Contraceptives
Definition

- Migraines

- HTN

- Galbladder disease

- History of gestational diabetes

- Smoking

- Epilepsy

- Jaundice with pregnancy

- Sickle cell anemia

- Lactation

- Hyperlipidemia

 

Term
What drugs Induce and Inhibit the metabolism of OC's?
Definition

Inducers: Rifampin, Phenytoin, Sulfonamides, Tetracyclines

 

Inhibitors:  Ketoconazole, Fluconazole

 

Use backup method for whichever is longer, Abx + 2 weeks, or the remainder of the cycle.

Term
What is special in regards to Seasonale?
Definition

- Combo

- Quarterly menstruation

- 91 days on, 7 days off

- Could prevent anemia and endometriosis

- Disadvantages:  Prolonged exp. to hormones so more likely for DVT, could have 20 days of bleeding at start.

Term
What is special in regards to Seasonique?
Definition

- Same as Seasonale except........

- 84 days on combo, 7 days of low dose estrogen

 

Seasonique is UNIQUE in that regard

Term
What are the advantages and disadvantages of progestin-only contraceptives?
Definition

- Useful in pt's with certain CI's

- Avoid estrogen ADR's

- Includes Micronor, Nor QD, Ovrette

- Less effective than combos, 40% may still ovulate

- May cause spotting or ectopic pregnancy

Term
What is special in regards to Ortho Evra?
Definition

- Not for fatties > 90kg (198 lbs)

- Combo

- Use q week with one week off

- Apply pretty much any hairless area

- 2x risk of DVT

Term
What is special in regards to Nuva Ring?
Definition

- Combo

- Remains in for 3 weeks, out  for 1

- Can be taken out for up to 3 hours

- Risks same as OC

Term
What is special in regards to Mirena?
Definition

- T shaped IUD

- Progestin only

- in place for 5 years

- 0.1% failure

- counsel on PAINS

- PID/Pregnancy, abdominal pain, infection, not feeling well string (change in length means it moved)

Term
What is special in regards to Depo Provera?
Definition

- Progestin-only  injection

- Need compliance (Preg. test before each injection)

- Decreases in bone density

- Delay of fertility of 10 months

- 3% failure.

- Really not to use in patients under 20 y/o or for longer than 2 years (bones)

Term
What is special in regards to Implanon?
Definition

- Implanted in arm

- Effective for 3 years

- 0.3% failure

- Progestin only

- Inhibits ovulation, alters endometrium

- 68 mg of etonogestrol, active metab. of desogestrol

Term
What is special in regards to the newer products?
Definition

- 24 day and continuous dosing to reduce menstrual sx

- Includes Yaz and Lybrel. 

- Lybrel is first continuous dosing OC

- These are combos

Term
When would you take EC, and what options are available?
Definition

- Within 72 hours after unprotected sex, decreases chance of pregnancy 75-89%

- Can be used up to 120 hours after sex

- Plan B one step (w/o a script if >17), Copper IUD, and Yuzpe (5 pills of one OC, then another 5 pills 12 hours later) method available

Term
What is the main side effect of emergency contraception?
Definition
Irregular bleeding, nausea
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