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Psychotropic Drugs
From Fundamentals of Psychiatric Mental Health Nursing (Varcarolis)
35
Nursing
Undergraduate 3
01/19/2011

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Term
Functions of the brain (1)
Definition
Monitor changes in the external world
Monitor composition of bodily fluids
Regulates contractions of skeletal muscles
Initiate and regulate the basic drives
Conscious sedation
Term
Functions of the brain (2)
Definition
Memory
Mood
Thought
Regulate sleep cycle
Language
Process visual and auditory data
Term
Biological issues
Definition
Understanding normal and abnormal mental processes in terms of brain function
Disturbances in client's behavior is due to alterations in cerebral function
Treat disorders with meds and psychotherapy
Term
Neurotransmitters
Definition
Dopamine
Norepinephrine
Serotonin
GABA
Acetylcholine
Histamine
Peptides
Term
Dopamine (increase/decrease)
Definition
Increase: Schizophrenia, mania
Decrease: Parkinson's disease, depression
Term
Norepinephrine (increase/decrease)
Definition
Increase: mania, anxiety states, schizophrenia
Decrease: Depression
Term
Serotonin (increase/decrease)
Definition
Increase: Anxiety states
Decrease: Depression
Term
GABA (increase, decrease)
Definition
Increase: Reduction of anxiety
Decrease: Anxiety disorder, schizophrenia, Huntington's chorea, mania
Term
Acetylcholine (increase/decrease)
Definition
Increase: Depression
Decrease: Alzheimer's, Huntington's, Parkinson's diseases
Term
Antipsychotics: Extrapyramidal SE
Definition
Parkinsonian symptoms
Akinesia
Akathisia
Tardive Dyskinesia
Term
Antipsychotics: Effects of increased prolactin
Definition
Gynecomastia
Galactorrhea
Term
Antipsychotics: Effects of Muscarinic Blockage
Definition
Blurred vision
Dry Mouth
Constipation
Urinary Difficulty
Term
Antipsychotics: Effects of Alpha1 Antagonism
Definition
Orthostatic hypotension
Failure to ejaculate
Term
First Generation Antipsychotics
Definition
These drugs block dopamine and some muscarinic and alpha receptors
*Treats few symptoms
Term
Atypical Antipsychotics
Definition
Block receptors in limbic system, rather than basal ganglia
*Treats more symptoms with fewer SE
Term
Trycyclic Antidepressants
Definition
Primarily blocks NE
*SE cause more problems
**Easy to overdose
Term
SSRI Antidepressants
Definition
Only block serotonin receptors
*Less side effects
**May increase suicidal ideations
Term
MAOI Inhibitors
Definition
Inhibit MAO from destroying monoamines
*Increased food-drug and drug-drug interactions
Term
Atypical Antidepressants
Definition
Not much is understood about how these work
Term
Mood Stabilizers
Definition
Lithium
*Antiepileptic Drugs
Tegretol
Depakote
Lamictal
Neurontin
Topamax
Trileptal
Term
Anti-anxiety drugs
Definition
Benzodiazepines
Short-acting sedative hypnotics
Melatonin receptor agonists
Buspirone(BuSpar)
Term
Benzodiazepines
Definition
Allows GABA to inhibit neurons more effectively
*Dangerous when combined with other CNS depressants
**Very addictive
Term
Short-acting sedative hypnotics
Definition
Sedative without anti-anxiety, anti-convulsant, or muscle relaxant
Term
Melatonin receptor agonists
Definition
Treats insomnia without dependency issues
Term
BuSpar
Definition
Reduces anxiety without causing drowsiness
*Decreased risk for dependency
Term
Lithium toxicity
Definition
Early signs may go away in 2 weeks
S/S: Ataxia, confusion, convulsions, n/v, diarrhea, polyuria, polydipsia, edema, goiter, and hypothyroidism
Term
ADD Drugs
Definition
Ritalin
Amphetamines
Term
Alzheimer's drugs
Definition
Anticholinesterase:
Cognex, Aricept, Reminyl, Excelon
Noncompetitive NMDA receptor agonist:
Namenda, Ebixa
Term
Neuroleptic Malignant Syndrome S/S
Definition
S/S: Severe muscle rigidity, ocylogyric crisis, dysphasia, hyperpyrexia (HTN, tachycardia, incontinence)
*This is a medical emergency
Progresses from delirium to stupor to coma.
Term
Extrapyramidal Symptoms
Definition
Nonvoluntary movements: akathisia, acute dystonia, pseudoparkinsonism
*Tardive dyskinesis is result if undetected
Term
Anticholinergic Side Effects
Definition
Dry mouth, blurred vision, tachycardia, constipation, urinary retention, and esophageal reflux
Term
Atropinic overload
Definition
S/S: erythema, confusion, and dehydration
**Be careful combining neuroleptic drugs with antihistamines and such
Term
Tx Withdrawal: Benzos
Definition
Sedatives that have anticonvulsant effects
*Serax, Ativan
Term
Withdrawal Tx: Thiamine
Definition
Vitamin B1 prevents Wernicke's encephalopathy
Term
Withdrawal Tx: MgSo4
Definition
Increases Vitamin B effectiveness
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