Term
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Definition
| How we get the drug into the nervous system: Administration, absorption/distribution, metabolism, elimination. |
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Term
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Definition
| How the drug binds to the site and produces an affect: drug receptor theory, dose-response curve |
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Term
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Definition
| activate the binding site and produce an effect |
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Term
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Definition
| activate binding site but no effect |
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Term
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Definition
| activate binding site but produce opposite effect |
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Term
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Definition
| Binds active site, but can be overcome with increased NT levels |
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Term
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Definition
| Binds not at active site and prevents NT binding, cannot be overcome with excess NT |
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Term
| Functional Agonists & Antagonists |
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Definition
| Increase or decrease levels of NT |
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Term
| Michaelis-Menten constant |
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Definition
| Affinity that a drug has for its binding site. |
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Term
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Definition
| Slope level= low slope gives us more ability to change dosages. |
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Term
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Definition
Amino Acids,
Monoamines,
Acetylcholine |
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Term
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Definition
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Term
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Definition
Neuropeptides,
Lipids,
Gases,
D-Amino Acids,
Purines,
Cytokines,
Prostaglandins |
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Term
| What is the classical neurotransmitter criterion? |
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Definition
1. Produced within neuron
2. Stored at presynaptic terminal
3. released when stimulated
4. React with pre/post receptors
5. Inactivated soon after release |
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Term
| How can we test whether something is a neurotransmitter? |
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Definition
1. Placement in the cleft produces physiologic effect.
2. Has a pharmacologic effect |
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Term
| What are the excitatory amino acids? |
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Definition
1. Glutamic acid (predominantly)
2. Aspartic acid
3. Cysteic acid
4. Homocysteic acid |
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Term
| What are the inhibitory amino acids? |
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Definition
1. GABA (predominantly)
2. Glycine
3. Taurine
4. Beta-alanine |
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Term
| What are the classic neuromodulatory systems? |
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Definition
Acetylcholine,
catecholamines,
serotonin |
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Term
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Definition
norepinepherine,
dopamine,
epinepherine |
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Term
| What do auxiliary subunits do? |
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Definition
| Mediate: receptor trafficking, gating, and pharmacology. |
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Term
| Name the scaffolding molecules: |
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Definition
synapse associated protein (SAP)
stargazin
gephryn |
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Term
| What are the synaptic adhesion molecules? |
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Definition
| neuroligins and neurexins (cadherins, integrins, dystroglycan, etc...) |
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Term
| What are shedding vessicles? |
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Definition
| Vessicles that are made up of lipid rafts that bud off and roam around extracellular fluid. |
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Term
| Name the non-classical neurotransmitters: |
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Definition
1. Neuropeptides
(endorphins, CRF, etc...)
2. Lipids (anandamide)
3. Gases (NO)
4. D-amino acids (serine)
5. Purines (adenosine)
6. Cytokines |
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