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Psychopharmacology Drugs
Drugs for Pharmacology Final (Dr. Quock)
114
Pharmacology
Professional
04/19/2012

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Term
trihexyphenidyl
Definition
anticholinergic drug (antiparkinson drug)
Term
benztropine
Definition
anticholinergic drug (antiparkinson drug)
Term
procyclidine
Definition
anticholinergic drug (antiparkinson drug)
Term
biperiden
Definition
anticholinergic drug (antiparkinson drug)
Term
diphenhydramine
Definition
anticholinergic drug (antiparkinson drug)
Term
L-Dopa
Definition
#1 drug used to treat Parkinsons Disease, immediate precurso of dopamine
Term
Pyridoxine
Definition
Vitamine B6 (cofactor for L-aromatic amino acid decarboxylase, increases the peripheral decarboxylation of L-DOPA)
Term
MAO-inhibitors
Definition
inhibit oxidative deamination of DA and NE and increase peripheral cardiovascular side effects of L-Dopa
Term
Phenothiazines
Definition
DA receptor antagonists and can prevent the antiparkinson effects of DA derived from L-DOPA
Term
carbidopa/L-DOPA
Definition
dopa decarboxylase inhibitor that inhibits conversion of L-DOPA to DA; increases antiparkinson effect of L-DOPA (more penetrates BBB)
Term
selegiline
Definition
MAOb inhibitor that prevents oxidative deamination of dopamine, increases antiparkinson effect of L-DOPA
Term
rasagiline
Definition
MAOb inhibitor that prevents oxidative deamination of dopamine, increases antiparkinson effect of L-DOPA
Term
tolcapone
Definition
COMT inhibitor that prevents peripheral metabolism of L-DOPA; increases antiparkinson effect of carbidopa/L-DOPA
Term
entacapone
Definition
COMT inhibitor that prevents peripheral metabolism of L-DOPA; increases antiparkinson effect of carbidopa/L-DOPA
Term
carbidopa/L-DOPA/entacapone
Definition
COMT inhibitor that prevents peripheral metabolism of L-DOPA; increases antiparkinson effect of carbidopa/L-DOPA (carbidopa cannot cross BBB, allows more L-DOPA to cross barrier before being converted to DA)
Term
bromocriptine
Definition
ergot agonists at D1 receptor; used as adjunct therapy to reduce dose of L-DOPA
Term
pramipexole
Definition
non-ergot agonist at D3 receptor; excreted unchanged in urine
Term
ropinirole
Definition
non-ergot agonist at D2 receptor; metabolized by liver
Term
rotigotine CDS
Definition
24-hour continuous delivery system (antiparkinson drug)
Term
amantadine
Definition
indirect dopamine receptor agonist; antiviral drug for influenza A2; releases DA from nerve endings in cases of mild parkinsonism
Term
tetrabenazine
Definition
reserpine-like DA depleting agent (used in Huntington's disease)
Term
haloperidol
Definition
DA receptor antagonist (used in Huntington's disease)
Term
pridopidine
Definition
DA stabilizer in clinical trials (used in Huntington's disease)
Term
physostigmine
Definition
AChE-inhibitor (experimental) (used in Huntington's disease)
Term
phenothiazines
Definition
classical (conventional) neuroleptics
Term
butyrophenones
Definition
classical (conventional) neuroleptics
Term
meprobamate
Definition
older anxiolytic drug
Term
methaqualone
Definition
older anxiolytic drug
Term
hydroxyzine
Definition
older anxiolytic drug
Term
doxepin
Definition
older anxiolytic drug
Term
chlordiazepoxide
Definition
benzodiazepine (anxiolytic drug)(intermediate onset, long duration of action, long-lived active metabolites)
Term
diazepam
Definition
benzodiazepine (anxiolytic drug)(fast onset, long duration of action, long-lived active metabolites)
Term
oxazepam
Definition
benzodiazepine (anxiolytic drug)(slow onset, short duration of action)
Term
lorazepam
Definition
benzodiazepine (anxiolytic drug) (intermediate onset, short duration of action)
Term
alprazolam
Definition
benzodiazepine (anxiolytic drug)(intermediate onset, short duration of action)
Term
flumazenil
Definition
blocks agonists and inverse agonists of benzodiazepines
Term
Buspirone
Definition
an azaspirodecanedione, agonist at presynaptic 5-HT(1A) receptors
Term
nortriptyline
Definition
secondary amine tricyclic antidepressant
Term
desipramine
Definition
secondary amine tricyclic antidepressant
Term
maprotiline
Definition
tetracyclic antidepressant
Term
imipramine
Definition
tertiary amine tricyclic antidepressant
Term
amitriptyline
Definition
tertiary amine tricyclic antidepressant
Term
fluoxetine
Definition
SSRI antidepressant
Term
paroxetine
Definition
SSRI antidepressant
Term
sertraline
Definition
SSRI antidepressant
Term
citalopram
Definition
SSRI antidepressant
Term
escitalopram
Definition
SSRI antidepressant (lowest sexual dysfunciton SE)
Term
buproprion
Definition
atypical antidepressant (NDRI)
Term
trazodone
Definition
atypical antidepressant (SARI)
Term
nefazodone
Definition
atypical antidepressant (SARI)
Term
venlafaxine
Definition
atypical antidepressant (SNRI)
Term
mirtazepine
Definition
atypical antidepressant (NaSSA)
Term
phenelzine
Definition
irreversible and non-selective MAO-inhibitor
Term
hydrazine
Definition
irreversible and non-selective MAO-inhibitor
Term
tranylcypromine
Definition
irreversible and non-selective MAO-inhibitor
Term
non-hydrazine
Definition
irreversible and non-selective MAO-inhibitor
Term
lithium carbonate
Definition
mood stabilizer and antimanic drug
Term
valproic acid, lamotrigine, quetiapine, ziprasidone, aripiprazole, fluoxetine/olanzapine
Definition
FDA approved drugs with antimanic activity
Term
carbamazepine
Definition
unlabelled use in manic syndrome
Term
dextroamphetamine or dexamphetamine
Definition
amphetamine derivative (stimulant drug)- more potent centrally
Term
lisdexamfetamine
Definition
prodrug (stimulant drug)
Term
levoamphetamine
Definition
amphetamine derivative (stimulant drug)- more potent peripherally
Term
racemic amphetamine
Definition
amphetamine derivative (stimulant drug)
Term
methamphetamine
Definition
amphetamine derivative (stimulant drug)
Term
methylphenidate
Definition
non-amphetamine stimulant
Term
dexmethylphenidate
Definition
non-amphetamine stimulant
Term
phenylpropanolamine
Definition
phenylethylamine anorexiants (caused hemorrhagic stroke)
Term
fenfluramine
Definition
phenylethylamine anorexiants (caused heart valve disease)
Term
fen-phen
Definition
combination of either enfluramine or dexfenfluramine plus the amphetamine-like drug phentermine (caused heart valve damage and primary pulmonary hypertension)
Term
Cannabis
Definition
stimulates the endogenous cannabinoid receptors CB1 and CB2; mimics the pharmacological effects of endocannabinoids
Term
synthetic THC(dronabinol, Marinol)
Definition
cannabinoid drug
Term
synthetic nabilone (Cesamet)
Definition
analog of dronabinol; cannabinoid drug
Term
rimbonabant (Acomplia)
Definition
withdrawn from market; inverse agonist at CB1 receptor, causes reduction in appetite, increased risk of diabetes 2 and dyslipidemia
Term
cocaine
Definition
inhibition of nerve conduction, inhibition of catecholamine reuptake mechanism, unspecified influences on brain serotonin mechanisms
Term
mescaline
Definition
psychedelic (hallucinogen)
Term
lysergic acid diethylamide
Definition
psychedelic (hallucinogen)
Term
psilocybin
Definition
psychedelic (hallucinogen)
Term
phencyclidine
Definition
dissociative (hallucinogen)
Term
ketamine
Definition
dissociative (hallucinogen)
Term
nitrous oxide
Definition
dissociative (hallucinogen)
Term
dextromethorphan
Definition
dissociative (hallucinogen)
Term
anticholinergics
Definition
deliriants (hallucinogens)
Term
chlorpromazine
Definition
phenothiazine (typical antipsychotic); high SED and OH
Term
fluphenazine
Definition
phenothiazine (typical antipsychotic); high antipsychotic potency and EPS, low SED, AC, OH
Term
Thioridazine
Definition
phenothiazine (typical antipsychotic); high SED, AC, low EPS
Term
Haloperidol
Definition
Butyrophenone (typical antipsychotic), high AP, EPS, low SED, AC, OH
Term
Clozapine
Definition
Atypical Antipsychotic (weight gain and sedation)
Term
Risperidone
Definition
Atypical Antipsychotic. High Sedation
Term
Olanzapine
Definition
Atypical Antipsychotic (high weight gain)
Term
Quetiapine
Definition
Atypical Antipsychotic (high sedation)
Term
Ziprasidone
Definition
Atypical Antipsychotic (low sedation and weight gain)
Term
Aripiprazole
Definition
Atypical Antipsychotic (low weight gain and sedation)
Term
cholinesterase inhibitors
Definition
used in dementia
Term
tacrin
Definition
cholinesterase inhibitor (mild-to-moderate alzheimers)
Term
donepezil
Definition
cholinesterase inhibitor (used in mild-to-severe alzheimer's)
Term
galantamine
Definition
cholinesterase inhibitor (mild-to-moderate alzheimers
Term
NMDA antagonist
Definition
prevention of glutamate excitotoxicity (used in dementia)
Term
memantine
Definition
NMDA antagonist (used in moderate-to-severe Alzheimer's) adverse effects: confusion, dizziness, drowsiness
Term
Antioxidants
Definition
neuroprotective effect against oxidative stress (Vitamin E = not approved)
Term
modafinil
Definition
approved to reduce sleep attacks in narcolepsy
Term
atomoxetine
Definition
selective NE reuptake inhibitor (non-stimulant approved for the treatment of ADHD in children, adolescents, and adults)
Term
phenelzine (Nardil)
Definition
Irreversible and non-selective MAO-inhibitor (hydrazine)
Term
tranylcypromine (parnate)
Definition
irreversible and non-selective MAO-inhibitor (non-hydrazine)
Term
meclobemide (Manerix)
Definition
reversible inhibitor of MAOa (RIMA)
Term
brofaromine (Consomar)
Definition
reersible inhibitor of MAOa (RIMA)
Term
MAO inhibitors + meperidine
Definition
paradoxical CNS excitation
Term
MAO inhibitor + sympathomimetic amine-containing medicines or tyramine-containing foods
Definition
acute hypertensive crisis
Term
Carbamazepine drug action
Definition
decreases NE release (stimulation of presynaptic adenosine receptors)
Term
Anandamide (AEA)
Definition
acts on CB1 and CB2 receptors
Term
2-arachidonoylglycerol (2-AG)
Definition
acts on CB1 receptors
Term
N-arachidonoyldopamine (NADA)
Definition
acts on CB1 receptors
Term
chlorpromazine
Definition
antidotal therapy for psychedelics (blocks both DA/SER)
Term
ketamine (prototype)- MAO
Definition
blocks NMDA receptor (reduction in pain but can't figure out where its coming from)
Term
Phencyclidine SE
Definition
PCP-MOST DANGEROUS (acure toxicity, combtiveness, catatonia, convulsions, coma)
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