Term
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Definition
Tricyclic Antidepressants
Tertiary Amines (>5-HT)
Antidepressant |
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Term
|
Definition
Tricyclic Antidepressants
Tertiary Amines (>5-HT)
Antidepressant
Anti-Anxiety (GAD) |
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Term
|
Definition
Tricyclic Antidepressants
Tertiary Amines (>5-HT)
Antidepressant
Anti-Insomnia |
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Term
|
Definition
Tricyclic Antidepressants
Secondary Amines (>NE)
Antidepressant |
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Term
|
Definition
Tricyclic Antidepressants
Secondary Amines (>NE)
Antidepressant |
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Term
|
Definition
Monoamine Oxidase Inhibitors (MAOIs)
Antidepressant
Anti-Anxiety |
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Term
|
Definition
Monoamine Oxidase Inhibitors (MAOIs)
Antidepressant
Anti-Anxiety |
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Term
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Definition
Monoamine Oxidase Inhibitors (MAOIs)
Antidepressant
Anti-Anxiety |
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Term
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Definition
Monoamine Oxidase Inhibitors (MAOIs)
Antidepressant
Anti-Anxiety |
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Term
|
Definition
Selective Serotonin Reuptake Inhibitors (SSRI)
Antidepressant
Inhibits several P450 enzymes --> many DDIs |
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Term
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Definition
Selective Serotonin Reuptake Inhibitors (SSRI)
Antidepressant
Anti-OCD |
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Term
|
Definition
Selective Serotonin Reuptake Inhibitors (SSRI)
Antidepressant |
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Term
|
Definition
Selective Serotonin Reuptake Inhibitors (SSRI)
Antidepressant |
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Term
|
Definition
Selective Serotonin Reuptake Inhibitors (SSRI)
Antidepressant
Anti-Anxiety |
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Term
|
Definition
Selective Serotonin Reuptake Inhibitors (SSRI)
Antidepressant
Anti-Anxiety |
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Term
|
Definition
Serotonin-NE Reuptake Inhibitor (SNRI)
Antidepressant
Anti-Anxiety
DOC in physical pain syndromes associated with depression |
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Term
|
Definition
Serotonin-NE Reuptake Inhibitor (SNRI)
Antidepressant
Anti-Anxiety |
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Term
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Definition
Serotonin-NE Reuptake Inhibitor (SNRI)
Antidepressant |
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Term
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Definition
NE-DA Reuptake Inhibitor (NDRI)
Antidepressant
NOT for Anxiety (don't confuse with Buspirone)
Dose-related Seizure Risk! |
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Term
|
Definition
SSRI + Alpha-2 blockade
Antidepressant
Net Effect: Increase NE and 5-HT at synapse. Also some anti-anxiety and anti-emetic effects |
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Term
|
Definition
SSRI + 5-HT-1A agonist
Antidepressant
SE: Very bad GI (titrate dose) |
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Term
|
Definition
5HT-2 receptor blockers and SSRI
Antidepressant
SE: Liver failure |
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Term
|
Definition
5HT-2 receptor blockers and SSRI
Antidepressant
Anti-Insomnia
Anti-Anxiety
SE: Priapism (erection > 4 hours) |
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Term
| Drugs with potential to INDUCE Depression |
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Definition
CV Drugs: Beta Blockers
Hormones: Corticosteroids, Estrogens, Progestins, Tamoxifen
Other: Indometacin, IFN, Narcotics |
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Term
|
Definition
Mood Stabilizer (1st line BPD)
Renally Excreted (monitor renal function)
Teratogenic (Pregnancy Test!) |
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Term
|
Definition
Anticonvulsants
Mood Stabilizer |
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Term
|
Definition
Anticonvulsants
Mood Stabilizer |
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Term
|
Definition
Anticonvulsants
Mood Stabilizer |
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Term
|
Definition
Anticonvulsants
Mood Stabilizer |
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Term
|
Definition
Anticonvulsants
Mood Stabilizer |
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Term
| Atypical Antipsychotics: Other uses |
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Definition
| Can also be used as Mood Stabilizers |
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Term
|
Definition
Benzodiazepines
Mood Stabilizers (not for Maintenance)
Anti-Anxiety (ideal due to intermediate half life, multiple dosage forms, and metabolic pathway) |
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Term
|
Definition
Benzodiazepines
Mood Stabilizers (not for Maintenance)
Anti-Anxiety |
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Term
|
Definition
Benzodiazepines
Anti-Insomnia |
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Term
|
Definition
Benzodiazepines
Anti-Insomnia |
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Term
|
Definition
Benzodiazepines
Anti-Insomnia |
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Term
|
Definition
Benzodiazepines
Anti-Insomnia (long half-life) |
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Term
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Definition
Benzodiazepines
Anti-Insomnia (long half-life) |
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Term
|
Definition
BZPD1 Agonists
Anti-Insomnia
Daytime Sommnelence |
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Term
|
Definition
BZPD1 Agonists
Anti-Insomnia
Daytime Somnelence |
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Term
|
Definition
BZPD1 & GABA Receptor Agonists
Anti-Insomnia
Useful for Chronic Insomnia, no tolerance (except at higher doses)
Bad Taste |
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Term
|
Definition
Melatonin Agonists
Anti-Insomnia |
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Term
|
Definition
Phenothiazines
Typical Anti-Psychotics (FGA) |
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Term
|
Definition
Phenothiazines
Typical Anti-Psychotics (FGA) |
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Term
|
Definition
Phenothiazines
Typical Anti-Psychotics (FGA) |
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Term
|
Definition
Phenothiazines
Typical Anti-Psychotics (FGA) |
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Term
|
Definition
Phenothiazines
Typical Anti-Psychotics (FGA) |
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Term
|
Definition
Phenothiazines
Typical Anti-Psychotics (FGA) |
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Term
|
Definition
Butyrophenones
Typical Anti-Psychotics (FGA) |
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Term
|
Definition
| Typical Anti-Psychotics (FGA) |
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Term
|
Definition
| Typical Anti-Psychotics (FGA) |
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Term
|
Definition
| Typical Anti-Psychotics (FGA) |
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Term
|
Definition
Atypical Anti-Psychotics (SGA)
Most Effective
SE: EPS and agranulocytosis (lower WBC)
Need to enroll in Monitoring Program in order to prescribe! |
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Term
|
Definition
Atypical Anti-Psychotics (SGA)
Greatest EPS at higher Doses
Give to elderly (in low doses) |
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Term
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Definition
Atypical Anti-Psychotics (SGA)
Like Clozapine, no agranulocytosis
SE: Weight Gain and metabolic effects |
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Term
|
Definition
Atypical Anti-Psychotics (SGA)
DOC for Parkinson patients, fairly clean. |
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Term
|
Definition
Atypical Anti-Psychotics (SGA)
Less Weight gain and metabolic effects
QT elongation (maybe overblown) |
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Term
|
Definition
Benzodiazepines
Anti-Anxiety |
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Term
|
Definition
Benzodiazepines
Anti-Anxiety |
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Term
|
Definition
Benzodiazepines
Anti-Anxiety |
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Term
|
Definition
Benzodiazepines
Anti-Anxiety |
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Term
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Definition
Tricyclic Antidepressants
Anti-Anxiety (OCD) |
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Term
|
Definition
Anti-Anxiety
High Affinity for 5HT1A and 5HT2 Receptors.
No effect on muscle relaxation and seizures
No CNS depression or tolerance/addiction.
SE: Dizziness, DDIs with 3A4 inhibitors, potential for Serotonin Syndrome |
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Term
| Benzodiazepines Key Concepts: |
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Definition
Enhance Inhibitory effect of GABA
Anxiolytic, Hypnotic, muscle relaxation, Anticonvulsant, amnesia, tolerance dependence.
Do not abruptly withdraw
Choice Based on Half-life, Dosage Forms, and metabolic pathway |
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Term
| Specific Treatment for Major Depressive Disorder |
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Definition
SSRI's are drug of choice.
Duloxetine (SNRI) is DOC in physical pain associated with depression. |
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Term
| Specific Treatment for Premenstrual Dysphoric disorder (PMDD) |
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Definition
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Term
| Specific Treatment for Bipolar Affective Disorder (BPAD) |
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Definition
Lithium is first line (onset 1-2 weeks)
Manage acute agitation with Benzo or Atypical Antipsychotics)
BP1: may combine with Carbamazepine
Valproic Acid DOC for Rapid cyclers
Lamotrigine/SGA/Lithium used for MDE associated with BPAD (stabilizes mood before placing on antidepressant) |
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Term
| Specific Treatment for Psychotic Disorders |
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Definition
| Atypical Antipsychotics (SGA) due to treatment of both Positive and Negative symptoms (efficacy probably same as FGA though) |
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Term
| Specific Treatment for Generalized Anxiety Disorder (GAD) |
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Definition
Benzodiazepines: Lorazepam is DOC
Antidepressants: Imipramine, Trazodone, SSRIs/SNRIs (duloxetine, venlafaxine FDA approved)
Buspirone |
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Term
| Specific Treatment for Panic Disorders |
|
Definition
Benzodiazepines (preferably Lorazepam or Oxazepam - not oxidatively metabolized)
Antidepressants: MAOIs (panic disorder + atypical depression) or SNRIs/SSRIs (venlafaxine) |
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Term
| Specific Treatment for OCD |
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Definition
SSRIs: Fluvoxamine
TCA: Clomipramine |
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Term
| Specific Treatment for PTSD |
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Definition
| SSRIs: Sertraline, Paroxetine |
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Term
| Specific Treatment for Insomnia |
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Definition
Drugs generally NOT first line!
Benzodiazepines: Temazepam DOC, Only for short term (2-4 weeks)
BZDP1 Agonists: Eszopiclone (Lunesta) for long term treatment |
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Term
| Specific Treatment for Insomnia with Commitant Depression |
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Definition
| Amitriptyline (TCA) and Trazodone |
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