Term
| Antipsychotics are good for __ __, __ __, __, and ___. |
|
Definition
- bipolar mania
- bipolar maintenance
- tourettes
- PTSD |
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Term
| Typical antipsychotics are __ __ ___ and ___, meaning they tend to cause movement disorders. Typicals are good at treating __ psychotic symptoms. They have __ and __ side effects. |
|
Definition
- D2 receptor antagonists
- neuroleptics
- positive
- extrapyramidal and anticholinergic side effects |
|
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Term
| Typical Antipsychotic Drugs: |
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Definition
Low Potency(TC): Thioridazine, Clorpromazine
Medium Potency(PT): Perphenazine, Trifluoperazine
High Potency(HP): Haloperidol, Pimozide |
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Term
| The low potency typical antipsychotics __ the ___ __, while the high potency typical antipsychotics are more likely to cause ___. |
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Definition
- decrease the seizure threshold (Thioridazine, Clorpromazine)
- EPS (Haloperidol, Pimozide) |
|
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Term
| Low potency typical antipsychotics have more/less sedative effect than high potency? |
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Definition
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Term
| Perphenerzine and Trifluoperazine are both __ potency typical antipsychotics. But ___ has less sedative effect and causes less EPS. |
|
Definition
- Medium potency
- Perphenerzine |
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Term
| Atypical antipsychotics are __ and __ receptor __. They have less __. They have __ SE. |
|
Definition
- dopamine and serotonin receptor blockers
- less EPS
- anticholinergic |
|
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Term
|
Definition
CAROZQP
- Clozapine
- Aripiprazole
- Respiradone
- Olanzapine
- Quetiapine
- Ziprasidone
- Paliperidone |
|
|
Term
| Clozapine is an __ antipsychotic. SE include decreased __ __, __ __, increased risk for __ and __, and ___. With this drug, a __ must be performed weekly. |
|
Definition
- atypical antipsychotic
- decreased seizure threshold
- weight gain
- increased risk for dyslipidemia and diabetes
- AGRANULOCYTOSIS
- CBC |
|
|
Term
| The main side effect of concern with Clozapine is: |
|
Definition
|
|
Term
| What are the atypical antipsychotics approved for Bipolar d/o? |
|
Definition
AROQZ
- Aripiprazole
- Resperidone
- Olanzapine
- Quetiapine
- Ziprasidone |
|
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Term
| Respiradone is an atypical antipsychotic but is also a potent __ ___ __. SE include __ and a __ __. |
|
Definition
- dopamine receptor antagonist
- hypotension
- prolonged QT interval |
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|
Term
| Olanzapine is an __ antipsychotic. SE include __ __, increased risk for __ and __. |
|
Definition
- atypical
- weight gain
- diabetes
- dyslipidemia |
|
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Term
| Quetiapine is an __ antipsychotic that has a strong __ side effect. |
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Definition
|
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Term
| Ziprasidone is an __ antipsychotic that is approved for __ d/o. It is also good for __ b/c it has a __ in it. SE include a __ __ __. |
|
Definition
- atypical antipsychotic
- bipolar
- depression
- TCA
- prolonged QT interval |
|
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Term
| Paliperidone is an __ antipsychotic that has a __ __ and is a more pure formulation of __, thus it lasts __ and has __ SE. |
|
Definition
- atypical
- slow release
- Risperidone
- longer
- fewer SE |
|
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Term
| Mood stabilizers are used with __ for treatment of __. They are also used for long-term maintenance against __ and __ in bipolar d/o and impulsive d/o. |
|
Definition
- antipsychotics
- mania
- depression
- mania in bipolar d/o |
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Term
| Most mood stabilizers also have __ __ properties. |
|
Definition
|
|
Term
|
Definition
LVDLVC:
- Lithium
- Valproate sodium
- Divalproex sodium
- Lamotrigene
- Valproic Acid
- Carbamazepine |
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Term
| Lithium is a mood stabilizer that is first line for __ cycling bipolar disorder, as long as __ function is normal.Levels must be monitored frequently. 5% on long term treatment develop ___, so __ should be monitored regularly. It has a small therapeutic window of ___. |
|
Definition
- REGULAR cycling bipolar
- renal
- hypothyroidism
- TSH
- 0.6-1.1mEq/L |
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Term
| Valproate Sodium, Divalproex Sodium, and Valproic Acid are __ __ that are better than lithium for the treatment of __ cycling bipoloar and mixed bipoloar. These do NOT help with prophylaxis for __ and do NOT augment ___. Monitoring of ___ function is essential in first 6 months b/c __ may occur. Other SE include __, __ __, __ __, __ __, and __. |
|
Definition
- mood stabilizers
- RAPID cycling bipolar
- NOT for depression or augmentation of antidepressants (lithium can be used here)
- liver function
- hepatotoxicity
- sedation
- mild tremor
- mild ataxia
- GI distress
- Thrombocytopenia |
|
|
Term
| Valproate Sodium therapeutic levels: |
|
Definition
|
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Term
| Lamotrigine is a __ __ that is approved for the treatment of __ __ but not for __. It is effective at treating the __ but NOT the __ _. Monitor for reactions with other drugs, especially Valproic Acid. SE include; |
|
Definition
- mood stabilizer
- bipolar I d/o but NOT for mania
- depression but NOT the manic phase
- ataxia
- blurred vision
- diplopia
- dizziness
- N&V
- STEVEN-JOHNSON SYNDROME |
|
|
Term
| The main SE of concern with Lamotrigine: |
|
Definition
| STEVEN JOHNSON SYNDROME (SO MAKE SURE AND WARN ABOUT RASH) |
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Term
| Carbamazepine is a __ __ that is considered an __ __ __ line drug for treatment of __ after __ and __ __ have failed. Like Valproic acid, it is better for __ cyclers than lithium. SE include: |
|
Definition
- mood stabilizer
- off label second line
- mania after lithium and valproate have failed
- rapid
- nausea
- rash
- mild leucopenia
- toxic levels: autonomic instability, AV block, respiratory depression, coma, agranulocytosis, pancytopenia, aplastic anemia |
|
|
Term
| Should Carbamazepine levels be monitored? Why? |
|
Definition
| Yes b/c can cause agranulocytosis so need to monitor for signs of bone marrow suppression |
|
|
Term
| Therapeutic level for Carbamazepine: |
|
Definition
|
|
Term
| Benzodiazepines are ___. If you quit them suddenly, __ may occur. |
|
Definition
|
|
Term
|
Definition
- Anxiety d/o
- In conjugation with antidepressants
- Insomnia
- Alcohol withdrawal
- Mania
- Dementia
- Catatonia
- Psychotic disorder |
|
|
Term
|
Definition
ACCDOLFTT
- Alprazolam
- Chlordiazepoxide
- Clonazepam
- Diazepam
- Oxazepam
- Lorazepam
- Flurazepam
- Temazepam
- Triazolam |
|
|
Term
| __ onset benzodiazepines produce a "high" feeling and are more addictive. These include: |
|
Definition
- Fast onset (DFT)
- Diazepam (Valium)
- Flurazepam
- Triazolam |
|
|
Term
|
Definition
"O"
- Oxazepam- for alcohol withdrawal |
|
|
Term
| Intermediate onset benzo: |
|
Definition
ACCLT:
- Alprazolam
- Chlordiazepoxide
- Clonazepam
- Lorazepam
- Temazepam |
|
|
Term
|
Definition
DFT:
- Diazepam
- Flurazepam
- Triazolam |
|
|
Term
| 2 benzos used for EtOH detox: |
|
Definition
- Oxazepam
- Chlordiazepoxide |
|
|
Term
|
Definition
FFSPCE
- Fluoxetine
- Fluvoxemine
- Sertraline
- Paroxetine
- Citalopram
- Escitalopram |
|
|
Term
| SNRIs inhibit uptake of serotonin and NE, increasing both levels in the synaptic cleft: |
|
Definition
- Venlafaxine
- Duloxetine |
|
|
Term
| Serotonin receptor agonists and antagonists: |
|
Definition
|
|
Term
| Norepinephrine-Dopamine Reuptake Inhibitor (NRDI): |
|
Definition
|
|
Term
| Trazodone is used for its __ properties. Main SE to look out for is ___, especially in adolescent males. |
|
Definition
|
|
Term
| Pros and Cons of Buproprion: |
|
Definition
Pros: low incidence of sexual side effects, effective in smoking cessation
- Cons: lowers seizure threshold |
|
|
Term
| Tricyclic Antidepressants (TCAs) block presynaptic uptake of __ and __. Levels must be monitored. |
|
Definition
|
|
Term
|
Definition
NIDC:
- Nortriptyline
- Imipramine
- Desipramine
- Clomiprimine |
|
|
Term
|
Definition
- Orthostatic hypotension (do not use in elderly)
- Anticholinergic SE
- Cardiac toxicity
- Sexual dysfunction |
|
|
Term
| Monoamine Oxidase Inhibitors (MAOIs) inhibit monoamine oxidase and thus prevent the breakdown and increase levels of __, __, and __. |
|
Definition
- serotonin
- NE
- dopamine |
|
|
Term
|
Definition
- Tranylcypromine
- Isocarboxazid
- Phenelzine |
|
|
Term
| Mirtazapine is an ___ that is classified as a __ of __ and ___. It is very __ but has low risk of __ side effects. |
|
Definition
- antidepressant
- modulator of serotonin and NE
- sedating
- low risk of sexual side effects |
|
|
Term
| Describe Behavioral Therapy and 3 aspects of it: |
|
Definition
Behavioral therapy: idea that if a person follows rules they receive a reward and if they do something wrong, the reward is removed
- Modeling: form of learning based on observing others and imitating their actions and responses
- Classical conditioning: pairing a neutral stimulus with natural stimulus
- Operant conditioning: form of learning in which enviornmental events influence the aquisition of new behaviors and extinction of existing behaviors |
|
|
Term
| Cluster A Personality D/O: |
|
Definition
Odd and Eccentric (PSS)
- Paranoid- paranoid of others
- Schizoid- detached, loners
- Schizotypal- minor schizophrenia, odd perceptions, thoughts, affect, and beliefs |
|
|
Term
| Clustser B Personality D/O: |
|
Definition
Dramatic and Emotional (ABHN):
- Antisocial- disregard rules and others, no remorse, usually criminal hx, lie often, endager others, impulsive, aggressive, EtOH abuse is common
Borderline: unstable relationships, self destructive urges often result in suicide attempts
- Histrionic: excessive superficial emotionality and powerful need for attention, theatrical behavior, lively and dramatic clothing, inappropriate flirting
- Narcissistic: arrogant and entitled but very low self esteem, self centered, but feel worthless, sens of self importance is extravagant, exaggerated emotional responses, absent empathy/concern for others |
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