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Protozoan parasites
blood & tissue protozoan parasites
18
Medical
Post-Graduate
04/13/2008

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Term
leishmania mexicana
Definition
cutaneous leishmaniasis
vector: sandfly
South and Central America
Term
leishmania braziliensis
Definition
cutaneous leishmaniasis
vector: sandly
South & Central American
tx: pentavalent antimonials, pantamidine, amphotericin B
Term
leishmania braziliensis
Definition
mucocutaneous leishmaniasis (severe, disfiguring facial lesions)
vector: sandfly (salivary glands)
South and Central America
tx: pentavalent antimonials, pantamidine, amphotericin B
Term
leishmania major
Definition
cutaneous leishmaniasis
vector: sandfly
Asia, Africa, Med. Europe, Middle East, S regions of former Soviet Unions

tx: pentavalent antimonials, pantamidine, amphotericin B
Term
leishmania tropica
Definition
cutaneous leishmaniasis
vector: sandfly
Asia, Africa, Med. Europe, Middle East, S regions of former Soviet Unions

tx: pentavalent antimonials, pantamidine, amphotericin B
Term
leishmania donovani
Definition
visceral leismaniasis (tropism for M0 of liver and spleen)
Asia, Africa, SE ASia
vector: sandfly
tx: pentavalent antimonials, pantamidine, amphotericin B
Term
leishmania infantum
Definition
visceral leismaniasis (tropism for M0 of liver and spleen)
Mediterranean basin (esp children)
vector: sandfly
tx: pentavalent antimonials, pantamidine, amphotericin B
Term
leishmania chagasi
Definition
visceral leismaniasis (tropism for M0 of liver and spleen)
South and Central America
vector: sandfly
tx: pentavalent antimonials, pantamidine, amphotericin B
Term
Leishmania life cycle
Definition
1. promastigote (extracell in sandfly; motile)
2. metacyclic promastigote (motile, resist C' lysis)
3. amastigotes (no flagella, persist and replicate phagolysosome)
Term
trypanosoma brucei gambiense
Definition
African sleeping sickness

reservoir: domestic pigs
vector: tse tse fly (glossina)
West and Central Africa

cyclic fever pattern and parasitemia
no intracellular amastigote stage
Term
trypanosoma brucei rhodesiense
Definition
African sleeping sickness

reservoir: cattle and sheep
vector: tse tse fly (glossina)
East Africa (esp hunters, travelers)

cyclic fever pattern and parasitemia
no intracellular amastigote stage
Term
trypanosoma cruzi
Definition
Chagas' Dx
insect vector: kissing bugs - reduviid bugs (hindgut)
reservoir: dogs/cats, rodents, armadillos, racooms, oppossums...

tropism for cells of M0 lineage, cardiac m, glial cells
Term
Trypanosoma life cycle
Definition
1. epimastigote (memb-assoc flagellum; insect vector)
2. trypomastigote (still motile, extracellular in host, divide via binary fission)
3. no amastigote - no intracellular form
Term
plasmodium falciparum
Definition
higher parasitemia
greater virulence

vector: female anopheline mosquito
Sub-saharan Africa
Term
plasmodium malariae
Definition
72 hr cycle of reproduction (fever)
infects senescent RBCs

vector: female anopheline mosquito
? location ?
Term
plasmodium vivax
Definition
vector: female anopheline mosquito
can persist as hypnozoites (recurrent)
SE asia, Indian subcontinent, Central and Latin America
Term
plasmodium ovale
Definition
vector: female anopheline mosquito

can persist as hypnozoites (recurrent)
SE asia, Indian subcontinent, Central and Latin America
Term
Plasmodium life cycle
Definition
3 cycles:
1. sporogonic cycle - in mosquito (sexual)
2. exo-erythrocytic - in hepatocyte (asexual)
3. erythrocytic - in RBC (sexual)
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