Term
| What does Class A of the prostaglandins contain? |
|
Definition
1 Keto Group
1 double bond |
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Term
| What does Class E of the prostaglandins contain? |
|
Definition
1 keto group
1 hydroxyl group |
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Term
| What does class F of the prostaglandins contains? |
|
Definition
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Term
| What inhibits the rate determining step of Phospholipid to Arachidonic Acid (catalyzed by the enzyme PLA 2) |
|
Definition
| Anti-inflammatory steroids |
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Term
| What inhibits the reaction of Arachidonic Acid to prostaglandins which is catalyzed by the enzyme cycoogenase? |
|
Definition
| NSAIDs (ex. Aspirin, Indomethacin, Phenylbutazone) |
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Term
| COX 1 is constitutive (always on) and is most inhibited by ? |
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Definition
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Term
| COX-2 is inducible, generated in response to inflammation and is inhibited by ? |
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Definition
|
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Term
| COX-1 mediates the production of what two things? |
|
Definition
| TXB A2 and prostaglandins |
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|
Term
| COX-1 keeps the integrity of what three things? |
|
Definition
| gastric mucosa, platelet function, renal blood flow |
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Term
| COX-2 Inhibitors include: Celecoxib (Celebrex), ?, and ? |
|
Definition
| Rofecoxib (Vioxx), and Meloxicam (Mobic) |
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