Term
| Drug-receptor interactions that produce desired physical or behavioral changes are called... |
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| The structures that separate the mother's blood from the fetal blood supply are called the... |
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| The closer a drug's pKa and the environmental pH, the more of the drug will be absorbed in that area. |
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| Which of the following may contribute to individual differences in drug metabolism? |
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Definition
| Age, gender, genetic polymorphism. |
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Term
| For most rapid absorption, the best way to administer a drug would be... |
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| Cheryl is out drinking with her friends. She has three drinks in one hour. How long will it take her body to process those three drinks? |
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| The therapeutic ratio is used to evaluate... |
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Definition
| drugs in human clinical trials. |
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Term
| The _____ carry blood away from the heart. |
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| Most drugs are biotransformed in the... |
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| Which of the following would be able to cross the blood-brain barrier? |
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Definition
| Nanoparticle drugs, lipid-soluble drugs, drugs that mimic or bind to substances with active transport mechanisms. |
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Term
| What is the LD50 of a drug? |
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Definition
| The level at which 50% of the subjects receiving that dose die. |
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Term
| The _____ carry blood toward the heart. |
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| _______ are the resulting widespread alterations in function that occur when a drug is ingested |
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| The pKa of a drug describes its... |
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Definition
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Term
| Most drugs are excreted through the... |
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Term
| The area postrema and the subfornical organ are examples of... |
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Definition
| weak spots in the blood-brain barrier, areas where blood can be monitored for toxins, warning sites to help protect the brain against harmful substances, circumventricular organs. |
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Term
| Which of the following can affect the absorption rate of a drug? |
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Definition
| The site of administration, the nature of solution containing the drug, the ionization ability of the drug, the body composition of the patient. |
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Term
| TD50 refers to the dose at which 50% of participants experience... |
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Term
| The ______ portion of a cell membrane faces outwards and is exposed to the extracellular space. |
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| The _____ allow exchange of nutrients and waste products and connect the other major types of blood vessels. |
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Definition
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| The _____ portion of a cell membrane faces inwards and is exposed to the intracellular space. |
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Definition
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Term
| Where is the circle of Willis? |
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Definition
| At the base of the brain. |
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Term
| _______ refers to specific molecular changes that occur when a drug binds to a particular target site or receptor |
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| John ingests one gram of cocaine. The half-life of cocaine is 90 minutes (1.5 hours). After six hours, how much of the cocaine will remain free in John's bloodstream? |
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| The drug Thalidomide was withdrawn in 1961 because... |
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Definition
| it was determined to be a teratogen. |
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| The typical drug-test by urinalysis is looking for... |
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