Term
| Where is CSF formed and absorbed? |
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Definition
Formed: choroid plexus of ventricles
Absorbed: arachnoid villi |
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Term
| What is the normal hourly and daily production of CSF? |
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Definition
Hourly: 21 ml
Daily: 500 ml |
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Term
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Definition
| choroid plexus - lateral ventricles - foramina of Munro - third ventricle - aqueduct of Sylvius - fourth ventricle - both Foramina of Lushka and Foramen of Magendie - SAS of spinal cord - brain - arachnoid villi |
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Term
| What does glutamate do when it attaches to the NMDA receptor? |
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Definition
| Produces conformational change that allows Na+ to flow through postsynaptic membrane |
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Term
| What effect does glutamate have on the Ca+ channels? |
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Definition
| Holds them open s Ca+ can continue down its concetration gradient |
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Term
| Why is the brain vulnerable to ischemia? |
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Definition
| It is vulnerable as it has a high O2 consumption and demand; also it is dependent on aerobic metabolism |
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Term
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Definition
| Edema occurs within minutes to hours of injury and is reversible; due to increased intracellular Ca+ and Na+ which causes the cell to take on water and swell |
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Term
| What type of cell death occurs initally in brain ischemia? |
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Definition
| apoptosis - which does NOT involve inflammation |
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Term
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Definition
| Occurs later in the ischemic cascade, the BBB leakds large molecules (including albumin) which creates osmotic pull and pulls water with it; occurs hours to days later and is NOT REVERSIBLE |
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Term
| What is the brain ischemia "triad" |
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Definition
| ischemia, decreased CPP, IICP |
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