Term
| Is safe and efficacious in the treatment of nausea and vomiting in pregnancy |
|
Definition
| Doxylamine, Droperidol, Metoclopramide, Pyridoxine |
|
|
Term
| Nausea and vomiting in pregnancy |
|
Definition
|
|
Term
| General physiologic and pharmacokinetic changes seen in pregnancy |
|
Definition
| decreased proportion of bound drug with highly protein bound medications |
|
|
Term
| Risks of using NSAIDs (including aspirin) during pregnancy |
|
Definition
| prolonged gestation/labor; oligohydramnios; hemorrhage; narrowing of the fetal ductus arteriosus |
|
|
Term
| The iPLEDGE program is associated with this drug |
|
Definition
|
|
Term
| Metabolic activity of CYP1A2 and 2C19 |
|
Definition
| often decreased during pregnancy |
|
|
Term
| Have an increased volume of distribution and decreased half life in pregnant women compared to non-pregnant |
|
Definition
|
|
Term
| after the embryonic period (between weeks 2 and 8 postfertilization) the conceptus is renamed this |
|
Definition
|
|
Term
| pregnancy lasts approximately: |
|
Definition
|
|
Term
| refers to the age of the embryo or fetus beginning with the first day of the last menstrual period which is about 2 weeks prior to fertilization |
|
Definition
|
|
Term
| the number of times a woman is pregnant |
|
Definition
|
|
Term
| number of pregnancies exceeding 20 weeks gestation; relates information regarding the outcome of each pregnancy |
|
Definition
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|
Term
| increases progressively; peak values on average 30% to 50% more than preconception levels by 25- to 30-weeks gestation |
|
Definition
|
|
Term
| hypercoagulability: risk of venous thromboembolism |
|
Definition
| 4 times greater in pregnancy |
|
|
Term
| expansion of both plasma and red blood cell volumes |
|
Definition
| leads to an expansion of total blood volume by approx. 1.5 to 1.6 L (40% increased in volume compared to non-pregnant women) |
|
|
Term
| overall decreased lung capacity by 5% |
|
Definition
| maternal oxygen consumption increases over gestation reflecting the increasing demands of the growing fetus and placenta |
|
|
Term
| renal blood flow increased across gestation |
|
Definition
|
|
Term
| renin-angiotensin aldosterone system |
|
Definition
| increased activity during pregnancy |
|
|
Term
| GI motility and gastroesophageal sphincter tone |
|
Definition
|
|
Term
|
Definition
| Absorption, distribution, metabolism, excretion |
|
|
Term
| do not survive due to the complexity of fertilization and subsequent pregnancy effects |
|
Definition
|
|
Term
| survive the first 2 weeks of gestation are lost spontaneously later |
|
Definition
|
|
Term
| baseline prevalence of major congenital malformations |
|
Definition
|
|
Term
|
Definition
| account for 20% of infant deaths |
|
|
Term
| birth defect risk is greatest |
|
Definition
|
|
Term
| the ability of an agent to cause a defect or malformation in a fetus |
|
Definition
|
|
Term
| Francis Kelsey refused to approve this in US despite culture and laws telling her to approve it |
|
Definition
|
|
Term
|
Definition
| Accutane (avoid in pregnancy) |
|
|
Term
| most modifiable cause of birth defects, no safe level of exposure, increased incidence of SIDS, Colic, Respiratory problems, Hospital admissions |
|
Definition
|
|
Term
| causes catecholamine release and vasoconstriction |
|
Definition
|
|
Term
| increases risk of CVD, toxins in tobacco smoke are responsible for majority of adverse health effects |
|
Definition
|
|
Term
| recommend iron in pregnancy |
|
Definition
|
|
Term
| Folic acid dosing in pregnancy |
|
Definition
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|
Term
| characterized by severe persistent vomiting; 3rd leading cause of hospitalization in pregnancy |
|
Definition
|
|
Term
| one of the most effective treatment options for N/V in the past |
|
Definition
| Bendectin (tri-ingredient product) |
|
|
Term
| 1st line for heartburn in pregnancy |
|
Definition
| calcium carbonate, magnesium hydroxide, aluminum hydroxide, sodium bicarbonate (best to avoid) |
|
|
Term
|
Definition
| Ranitidine, cimetidine (both cross placenta but are considered safe) |
|
|
Term
| treatment for constipation in pregnancy |
|
Definition
| bulk forming agents (bran, psyllium, methylcellulose) |
|
|
Term
| The higher the maternal plasma level |
|
Definition
| the higher the transfer to milk |
|
|
Term
| more medication can enter milk in colostral phase; limited volume of colostrum |
|
Definition
|
|
Term
| less medication enter; larger volume |
|
Definition
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