Term
| What percent of patients exposed to 85 dB A exposure over an 8-hour work day may develop a significant hearing loss? |
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Definition
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Term
| A ___ ___ is defined as a change for the worse in either structure or function, outside the rage of normal |
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Definition
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Term
Parts of an ototoxicity monitoring program:
-specific ___ for identification
-Timely ___ of at risk patients
-____ counseling
-___ evaluations |
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Definition
| criteria; identification; Pretreatment; Monitoring |
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Term
| What percent of patients over 65 years take NSAIDs weekly? |
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Definition
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Term
Typical for noise induced hearing damage to outer hair cells...
-can break ___ with sterocilia
-decoupling connections to the ___ membrane
-stereocilia may ___ into one large stereocilia |
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Definition
| crosslinks; tectorial; fuse |
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Term
| Focal damage from noise exposure is when ___% or more of the outer or inner hair cells are gone |
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Definition
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Term
| Examples of 100% noise dose? |
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Definition
| 90dBA for 8 hours, 95dBA for 4 hours, and 105dBA for 1 hours |
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Term
| What is the disadvantage imposed by an impairment sufficient to affect a person's efficiency in the activities of daily living? |
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Definition
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Term
| According to DiSogra, how many drugs are ototoxic? |
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Definition
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Term
| What are effects of lead on children? |
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Definition
| learning disabilities, hyperactivity, mental retardation, and decreased growth? |
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Term
Chelators:
-Are small molecules that easily bind to ___
-They can be used to remove excess ___ in the body
-They can be given __, __ or ___
-Two types are ____ and ___ |
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Definition
| metals; iron; IM, IV, subcutaneously; Difluromethylornithine (DFMO); Desferrioxamine (DFO) |
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Term
| What are considered significant changes in hearing? |
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Definition
| -greater than or equal to 20 dB change at one frequency or greater than or equal to 10 dB change at 2 adjacent frequencies |
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Term
The sensitive range for ototoxicity...
-Is a range used for ___ ___
-Most initial changes are seen within one octave below the ___ audible frequency
-It is the range that contains the uppermost frequency with a threshold of ___ dB SPL or lower and 6 lower consecutive frequencies in ___ octave steps |
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Definition
| early detection; highest; 100; 1/6th |
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Term
ABR Principles:
-Usually absent for ___ to ___ losses
-Is measured in DB ___ |
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Definition
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Term
| What are symptoms of temporary threshold shift? |
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Definition
| Tinnitus, sense of aural fullness, and loss of hearing sensitivity |
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Term
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Definition
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Term
| The "__________ law" cuts through the red tape such that cancer patients may have access to cutting-edge treatments that can save their lives |
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Definition
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Term
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Definition
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Term
| Children __ and older can participate in ultra-high frequency audiometric testing |
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Definition
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Term
| ____ is that the test identifies or diagnoses individuals that actually have a condition and ___ is that the test actually dismisses those patients who do not have a condition |
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Definition
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Term
| ___ has developed special transducers for assessing ultra-high frequency hearing |
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Definition
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Term
| ___ are adverse conditions that result from treatment by a physician |
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Definition
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Term
True or false:
The higher the level of tone frequency, the broader the frequency range affected |
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Definition
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Term
True or false:
ABRs are more sensitive to ototoxic changes that DPOAEs |
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Definition
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Term
| It is likely that mail ordered pharmaceuticals required by some insurance companies contributes to ___ |
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Definition
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Term
| ___ of hearing loss is associated with high cumulative dose, but ___ of loss is not |
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Definition
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Term
| Evidence suggests testing frequencies above ___ Hz is more sensitive than conventional audiometry |
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Definition
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Term
| ___ antioxidants donate an electron to stabilize atoms with unpaired electrons |
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Definition
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Term
| There _____ a strong correlation between smoking and development of hearing |
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Definition
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Term
| Lead is a ___, especially for children |
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Definition
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Term
Risk of HL with certain noise exposure levels over an 8 hours work day:
-80 dBA=___%
-85 dBA=___%
-90 dBA=___% |
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Definition
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Term
| ___ ___ is the disadvantage imposed by an impairment sufficient to affect a person’s efficiency in the activities of daily life |
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Definition
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Term
| A ___ is an actual or presumed inability to remain employed at full wages |
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Definition
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Term
| Organ of Corti wipeout is when ___% of the hair cells are gone over a variable portion of the basilar membrane |
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Definition
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Term
| What are the permissible exposure levels at 90, 95, 100, 105, 110, 115 dBA? |
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Definition
90-8 hours
95-4 hours
100-2 hours
105-1 hour
110-30 minutes
115-15 minutes |
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Term
ABR:
-what stimulus is usually used?
-What behavioral thresholds do click ABRs correspond to?
-How do neurons respond when the base of the cochlea is activated? When the apex is activated? |
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Definition
-clicks
-2-4 kHz
-Synchronously; at slightly different times |
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Term
| What does a chemical asphyxiant do? |
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Definition
| prevents the uptake of oxygen by the cells |
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Term
| What are 2 examples of a chemical asphyxiant? |
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Definition
| Carbon monoxide and hydrogen cyanide gas |
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Term
| What does this statement describe? "Nullify in practice FDA rules that prevent terminally ill patients from accessing treatments" |
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Definition
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Term
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Definition
-Detoxify free radicals
-Some reduce the formation of free radicals |
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Term
| What kind of antioxidant donates an electron to stabilize atom with unpaired electron |
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Definition
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Term
| What are some indirect antioxidants? |
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Definition
| Sodium thiosulfate (STS), N-acetylcysteine (NAC), Glutathione (GSH) & Glutathione Ester (GSHe), D-methionine (D-met), and Amifostine |
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Term
| adverse condition that results from treatment by a physician. Ex: aminoglycosides, loop diuretics, salicylates, etc. |
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Definition
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Term
| relating to or causing malformations of an embryo or a fetus. Ex: Accutane, thalidomide, Dilantin, diphenyl hydantoin, etc. |
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Definition
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Term
| Increase levels of endogenous antioxidant systems (like certain enzymes) |
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Definition
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