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Practice Exam 2
Ototoxicity
32
Audiology
Graduate
10/23/2017

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Cards

Term
What symptoms are reversible once drugs like salicylates and NSAIDs are ceased?
Definition
Tinnitus, mild high frequency HL, and vertigo
Term
What is used to treat malaria?
Definition
Quinine
Term
NSAIDs are prescribed for ___ and ___ damage from chronic inflammation and ___
Definition
edema; tissue; fever
Term
What percent of patients over 65 years take NSAIDs weekly?
Definition
70%
Term
What pathogen is suspected for the brain eating amoeba disease?
Definition
Naegleria fowleri
Term
___ is a shortage of potassium in the blood
Definition
hypokalemia
Term
What does edema mean?
Definition
abnormal accumulation of fluid beneath the skin
Term
Diuretics work on what part of the nephron?
Definition
loop of henle
Term
What is the most common diuretic used?
Definition
Furosemide or lasix
Term
What are some symptoms of nephrotoxicity?
Definition
decreased urination, thirst, increased heart rate, dizziness, and loss of appetite
Term
Gout is associated with ____
Definition
Hyperuricemia
Term
Salicylates:
1. What is the main ototoxic effect?
2. Can also cause bilaterally symmetrical ____ ___ (or flat) SNHL
3. Often recover within __-__ hours after drug is stopped; but may cause permanent ototoxic results in some
4. Other effects: ___ of frequency filtering, difficulty in ___ detection, and ___ understanding difficulties
Definition
1. HF tinnitus (mild, tonal, high frequency)
2. mild/moderate HF
3. 24-72
4. Broadening; temporal; speech
Term
Ibuprofen (advil and motrin), indomethacin (Indocin), naproxen (Aleve), celecoxib (celebrex), rofecoxib (Vioxx), and acetaminophen (tylenol) are all associated with what group of drugs?
Definition
NSAIDs
Term
What configuration of HL do macrolides cause?
Definition
Flat
Term
What are the symptoms of malaria?
Definition
Tinnitus, HL (usually HF loss with 4 kHz notch), headache, and nausea with vision changes
Term
The damage caused by aspirin is usually ___
Definition
temporary
Term
NSAIDs can often cause ___
Definition
ulcers
Term
___ is an amine that is stored in high concentrations in mast cells and basophils
Definition
Histamine
Term
___ drugs stay in the body for a long time and may predispose a person to later HL
Definition
Platinum
Term
Nephrotoxic effects of aminoglycosides may be ___
Definition
reversible
Term
True or false: about 20 million individuals in the US receive aminoglycoside therapy ever ear
Definition
False-4 million do
Term
Most permanent cases of ototoxic effects caused from loop diuretics occur in patients with ___ ___
Definition
kidney dysfunction
Term
A vasodilator dilates veins and blood vessels in kidneys which ___ blood pressure
Definition
decreases
Term
Quinine toxicity is also known as ___
Definition
cinchonism
Term
Is vancomycin an aminoglycoside?
Definition
No
Term
___ of HL is associated with a high cumulative dose, but ___ of loss is not
Definition
Risk; severity
Term
___ of the head and neck for cancer treatment can also affect hearing
Definition
Irradiation
Term
Children who have taken platinum drugs and have beaten cancer should be under surveillance to monitor ___ ___
Definition
hearing sensitivity
Term
There is a strong correlation between poor ___ function and development of HL when taking certain ototoxic drugs
Definition
kidney
Term
Hyperuricemia may lead to ___
Definition
gout
Term
What aminoglycosides are vestibulotoxic?
Definition
Streptomycin and Gentamicin
Term
What aminoglycosides are cochleotoxic?
Definition
Neomycin and amikacin
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