Term
| Kinases: transfer _________ from ____ |
|
Definition
|
|
Term
| ________ , _________ , _________ kinases |
|
Definition
| serine/threonine, tyrosine |
|
|
Term
| Once phosphorylation of the hydroxyl occurs, what happens? |
|
Definition
| signaling cascade ensuees |
|
|
Term
|
Definition
| a receptor tyrosine kinase involved in cell proliferation |
|
|
Term
| Binding of EGF causes.... |
|
Definition
| EGFR dimerization and auto-phosphorylation of intracellular domain. |
|
|
Term
| You can mimic ATP binding site or active site? |
|
Definition
| You can mimic either but in this case for EGFR they are mimicing the EGFR site. |
|
|
Term
| Transition state analog inhibitors |
|
Definition
| understanding of organic reaction mechanisms allows us to make reasonable deductions of reaction transition states |
|
|
Term
| Multisubstrate adduct inhibitors |
|
Definition
When the enzyme of interest joins two substrates, or catalyzes reaction of a coenzyme with a substrate, then we can conceive of making one molecule that either mimics the ternary complex, or the reaction transition structure.
More binding surface area translates to greater affinity. |
|
|
