Term
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Definition
| study of drug design to optimize PK,PD, pharmacology, and synthesis of new drug candidates |
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Term
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Definition
| study and design of drug formulations for optimal delivery, stability, PK, and patient acceptance |
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Term
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Definition
| study of biochemical and physiological effects of drugs on organisms |
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Term
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Definition
| study of cellular and molecular interactions of drugs with their receptors |
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Term
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Definition
| study of the factors that control or influence the concentration of drugs in various tissues or organs of the body |
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Term
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Definition
| study of toxic effects of drugs and chemicals |
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Term
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Definition
| study of inheritance of characteristics patterns of interaction between drugs and organisms to explain pharmacodynamics response |
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Term
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Definition
-IUPAC
-common name
-compound name
-generic name
-brand (trade) name |
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Term
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Definition
| conc. drug in octanol/conc. drug in aq. buffer |
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Term
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Definition
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Term
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Definition
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Term
| physical/chemical properties |
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Definition
-melting/boiling pt
-solubility
-molecular weight/shape
-acid/base properties
-chemical reactivity/stability
-molecular formula |
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Term
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Definition
| water solubility, H bonding, and lipid solubility |
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Term
| plays an important role in acid/base properties and ionization |
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Definition
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Term
| rate of extent of oral absorption is proportional to |
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Definition
-extent of ionization
-aqueous solubility
-lipid solubility
-pH of stomach/small intestine |
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Term
| chemical reactivity/stability is important in terms of |
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Definition
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Term
| chemical properties influence choice of |
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Definition
-dosage form
-shelf live
-drug-drug, drug-food incompatibilities |
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Term
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Definition
-natural
-semi synthetic
-synthetic |
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Term
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Definition
-pre 1930s
-plants
-animal tissues
-bacteria/fungi |
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Term
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Definition
-extracts using aqueous organic solvents
-mixtures of related and unrelated substances
-pharmacognosy and natural products |
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Term
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Definition
| study of medicinal drugs obtained from plants |
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Term
| diffcult in finding viable plant sources because of |
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Definition
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Term
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Definition
-starting material from natural sources (analogs)
-improved pharmacological effects
-difficult functional groups
-biotechnological-derived biomolecules |
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Term
| biotechnology-derived biomolecules |
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Definition
-isolated and identification of human gene DNA
-use of DNA to synthesize proteins in vitro
-modification of gene to improve properties of protein
-modification to the protein itself by enzymes |
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Term
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Definition
-1940s-1980s
-total synthesis from inexpensive starting materials
-small molecule libraries from simple structural changes
-control over structural features and properties
-controversy over natural v. synthetic vitamins |
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Term
| controversy over natural v. synthetic vitamins |
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Definition
-same chemical ingredient
-differ in degree of purity, inactive ingredients, by-products from 3rd world suppliers
-interest in contamination of natural products with heavy metals, noxious weeds, manufacturing by products |
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