Term
| Describe the compartments that drugs can be distributed in to and how much ? |
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Definition
1. ECF: 14L
plasma - 4L
Interstitial fluid - 10L
2.ICF: 28L
Total Body water: 42L |
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Term
| What is the calculation for Volume of distribution and how can it be rearranged? |
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Definition
Vd = Dosage/C0
C0 = initial plasma volume
it ca be rearranges to
C0 = Dosage/ Vd
Dosage = VdxC0 |
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Term
| Protein binding give examples |
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Definition
Albumin binds acidic proteins
i.e warfarin in 98% bound if displaced by sulfonamides it causes bleeding
B-globulin and Alpha 1 acid glycoprotein bind basic drugs |
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Term
methimazole
ADR
alternative? |
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Definition
| Used in hyper thyroidism, crosses placental barrier thus propylthiouracil is used it is highly protein bound and does not cross the placental barrier. |
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Term
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Definition
| only lipid soluble drugs are able to pass this barrier |
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Term
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Definition
| a high % of the drug is bound to plasma proteins, ie warfarin bound to albumin (98%) |
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Term
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Definition
| a high % of the drug is being sequestered in the tissue, this raises the possibility of displacement, for example verapamil and quinidine can displace digoxin for its binding site leading to digoxin toxicity. |
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