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pirotte Pharm
pharmacogenomics
23
Other
Not Applicable
10/24/2005

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Cards

Term
drugs metabolized by CYP2D6
Definition
TCA, anti-arrhythmics, BB, neuroleptics, opiods
Term
cyp450 of tca
Definition
CYP2D6
Term
cyp450 of anti-arrythmics
Definition
CYP2D6
Term
cyp450 of BB
Definition
CYP2D6
Term
cyp450 of neuroleptics
Definition
CYP2D6
Term
cyp450 of opioids
Definition
CYP2D6
Term
cyp450 of tolbutamide
Definition
CyP2C9
Term
cyp450 of warf
Definition
CyP2C9
Term
cyp450 of phenytoin
Definition
CyP2C9
Term
cyp450 of NSAIDs
Definition
CyP2C9
Term
drugs metabolized by CYP2C9
Definition
tolbutamide, phenytoin, warf, NSAIDs
Term
cyp450 with the greatest number of drugs
Definition
3A4
Term
mutation in what gene can cause prolonged QT in pts taking quinidine?
Definition
HERG
Term
what causes CML?
Definition
Bcr-Abl translocation
Term
what is the Philly chromosome?
Definition
extra short 22 after Bcr-Abl transloc
Term
what does 9 look like after the Bcr-Abl transloc?
Definition
longer
Term
what does the bcr-abl translation product do?
Definition
constituitive Tyr-kinase activity
Term
what drug inhibits the Bcr-Abl Tyr-kinase?
Definition
imatinib/Gleevec
Term
Her2-neu mutations associated with?
Definition
breast cancer
Term
Her2-neu mutant rx?
Definition
trastuzumab/Herceptin
Term
target of cetuximab?
Definition
EGFR
Term
cetuximab rx?
Definition
solid tumors i.e. colorectal
Term
target of bevacizumab
Definition
VEGF
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