Term
| Inhibitors of NA+ Channels |
|
Definition
| Tetrodotoxin & Saxitoxin, Cocaine and Lidocaine |
|
|
Term
|
Definition
| Tetraethylammonium (K+ channels only have ONE gate) |
|
|
Term
| Myelination's affect on capacitance and resistance |
|
Definition
R up 5000x C down 50xMultiple Sclerosis is loss of myelination, loss of motor function |
|
|
Term
| blocks voltage gated Ca++ channels, won't block AP, but will block secretion of NT's |
|
Definition
|
|
Term
| blocks some type of voltage-gated K+ channels...therefore have slow repolarization |
|
Definition
|
|
Term
| endopeptidase that breaks down vesicular fusion proteins...cant release NT b/c docking and fusion is dysfunctional= flacid paralysis |
|
Definition
|
|
Term
| endopeptidase, breaks down vesicular fusion proteins..inhibits GLYCINE (inhib NT)= spastic paralysis |
|
Definition
|
|
Term
| exaggerated Ach response and SLUD |
|
Definition
| Acetylcholinesterase inhibitors |
|
|
Term
| aka belladonna, muscarinic receptor blocker, dilates pupils |
|
Definition
|
|
Term
| Nicotinic receptor blocker, can be used to paralyze the diaphragm, |
|
Definition
|
|
Term
| 3 derivatives of Arachidonic Acid |
|
Definition
| COX, 5-Lipoxygenase, Epoxygenase |
|
|
Term
| Derivatives of Cyclooxegenase |
|
Definition
Thromboxanes- up plateletsProstacyclins- down platelets prostaglandins- up smooth muscle inflamation |
|
|
Term
|
Definition
| Leukotrienes- inflamm asthma |
|
|
Term
| Eicosonoids are derived from |
|
Definition
|
|
Term
| two phospholipases that lead to prod of Arach Acid |
|
Definition
|
|
Term
TGF-Beta type of mediator? type of kinase? Hetero/homo |
|
Definition
|
|
Term
NGF Receptor type of mediator? type of kinase? hetero/homo |
|
Definition
|
|
Term
LIF Receptor assoc protein? type of kinase hetero/homo |
|
Definition
JAK kinase is assoc protein (not part of receptor) TYR kinase HOMO |
|
|
Term
ANP receptor type of kinase? makes? |
|
Definition
not a kinase--Guanyly cyclase makes cGMP |
|
|
Term
Guanyly cyclase- soluble & particulate soluble... hetero/homo what are 3 subunit domains? Normally inactive...what is primary activator? example of particulate (memb bound) Guany. cyc? |
|
Definition
hetero heme-binding domain, dimerization domain, and guanylyl cyclase catalytic domain NO is primary activator Ex: ANP receptor |
|
|
Term
| what is homologous b/t all protein kinases regarding structure? |
|
Definition
catalytic subunit is homologous regulatory and autoinhib are diff |
|
|
