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Physiology Lab exam 1
Renal function, reflexes, muscles
23
Physiology
Undergraduate 3
03/02/2011

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Term
Urinalysis: Specific gravity below 1.007
Definition
hydration
Term
Urinalysis: Specific gravity above 1.010
Definition
Dehydration
Term
Urinalysis: Specific gravity above 1.035
Definition

abnormal

indicates high level of clucose, a contaminated sample, drugs, or dyes

Term

Urinalysis after 12 hours:

Specific gravity below 1.022

Definition
Renal impairment or nephrogenic diabetes insipidus
Term

Urinalysis after 12 hours:

Specific gravity below 1.010

Definition
Complete kidney failure
Term
Glucose in urine
Definition
diabetes mellitus
Term
Ketones in urine
Definition
diabetic ketosis or starvation
Term
Nitrite in urine
Definition
bacteria may be present in significant numbers. Gram negative rods are more likely to give a positive test
Term
Positive leukocyte esterase test
Definition

presence of white blood cells either as whole cells or as lysed cells.

Infection

Term
Bilirubin in urine
Definition

breakdown product of hemoglobin that should be conjugated by liver and excreted into the bile.

indicates hepatic disease or hepatobiliary obstruction.

Term
Urobilinogen test
Definition

distinguishes hepatic disease from hepatobiliary obstruction.

will be reduced if there is an obstruction. Will be elevated in other cases.

Term
Drinking 800 mL water
Definition
inhibits ADH production, so collecting tube will not be very permeable to water.
Term
What influences propagation speed?
Definition

myelination

 

Term
EMG
Definition
electromicrograph shows the average of everything that is happening in a muscle. Thousands of nerve and muscle action potentials happening at the same time.
Term
Nerve action potential
Definition
depolarization (or hyperpolarization) of a neuron resulting from the opening of voltage gated ion channels.
Term
Muscle action potential
Definition
Depolarization of muscle fibers caused by opeining of sodium channels because of ACh binding.
Term
Voltage minimum and maximum for nerve stimulation in frog muscle
Definition

.011 amp

.11 amp

Term
If action potentials are all or nothing, why is there a difference between minimum and maximum
Definition
The EMG measures all muscle activity, not a single action potential. The minimum ellicits a minimal level of activity while .11 amps ellicited action potentials in more muscle fibers.
Term
Minimum and maximum voltage needed to elicit contraction in muscle.
Definition

.07 amp

3.0 amp

Term
why is the voltage needed to elicit maximum contraction much greater than with stimulation of the sciatic nerve?
Definition
more motor units are stimulated when the nerve is stimulated than the muscle directly.
Term
What effect should curare have in each?
Definition
Curare blocks nicotinic ACh receptors, so it will stop contraction when the nerve is stimulated. When the muscle is stimulated, there should not be much effect.
Term
How can we distinguish experimentally the effect of curare from fatigue?
Definition

-rinse muscle and look for recovery

administer acetylcholinesterase inhibitor and look for recovery.

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