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Physiology Exam 1, Lecture 2: Membrane Potentials
Cell Physiology
21
Physiology
Graduate
08/22/2011

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Term
Are cells negatively or positively charged compared to the ECF?
Definition
Negatively
Term
What is the resting potential of a cell?
Definition
About -70mV in neurons
Term
Where is the potential charge of a cell?
Definition
Along the membrane
Term
Describe Ohm's Law
Definition
I=V/R
Current=Potential/Resistance
Term
Do membranes have a high or low electrical resistance?
Definition
High, because of the lipids in the membrane
Term
Define conductance
Definition
1/R
Measures how easily an ion can cross the cell membrane and affect its charge
Term
Why does a cell's conductance change?
Definition
Ion channels open and close
Term
Are cations positive or negatively charged? What about anions?
Definition
Cations are positive, anions are negative
Term
Define electrochemical potential
Definition
The algebraic sum of the electrical and chemical forces
Term
Define equilibrium potential
Definition
When the driving force of the concentration gradient for the ion is equal and opposite to the electrical force on the ion and thus there is no net movement of the ion across the membrane
Term
What is the equilibrium potential for K+?
Definition
-90mV
Term
What is the equilibrium potential for Na+?
Definition
+60mV
Term
What is the equilibrium potential for Cl-?
Definition
-72mV
Term
What is the importance of the chord conductance equation?
Definition
It shows how multiple ions affect the membrane potential of a cell
Term
Which has a higher conductance, K+ or Na+? Why?
Definition
At rest, K+ has a conductance of about 50x higher
Because there are many more leak channels for K+
Term
Define depolarization
Definition
decreased membrane potential, less negative, more positive
Term
Define hyperpolarization
Definition
Increased membrane potential, more negative, less positive
Term
Define repolarization
Definition
return of membrane potential to its resting level
Term
When does conductance of an ion change?
Definition
When a channel is opened or closed
Term
Define driving force
Definition
A measure proportional to the membrane potential minus the equilibrium potential for that ion
A higher driving force leads to larger current carried by that ion
Term
When considering if an ion will move across a membrane, do you take into account molarity or electric potential?
Definition
Electric potential
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