Term
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Definition
| a protein (amino acids that are coded by dna) |
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Term
| #1) Bond strength from weak to strong |
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Definition
van der Waals
Hydrogen
ionic
covalent |
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Term
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Definition
| Shifting electron density, transient positive or negative charge that interact with areas of opposite charge on another molecules |
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Term
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Definition
| Hydrogen atoms bound to nitrogen or oxygen that become positively polarized--> bond more negatively polarized atoms like o2, nitrogen, sulfur |
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Term
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Definition
| Atoms with an excess of electrons (thus negative) attracted to deficient atoms (thus positive) |
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Term
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Definition
Two bonding atoms share the electrons, mostly irreversible, very strong
eg aspirin |
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Term
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Definition
lipophilic portion of drug wants to bond to lipophilic part of receptor
not always drug as a whole that is considered lipophilic |
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Term
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Definition
| involves pH of body and pKa of drug |
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Term
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Definition
enantiomers (mirror images)
-racemic mixture-both mirror images included
-can isolate seperate enantiomers to market new drug
(eg celexa (citalopram-racemic) Lexapro-escitalopram, more active of mix) |
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Term
#5) Conformation
Molecular Drug-receptor interactions |
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Definition
Transmembrane
Intracellular
extracellular |
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Term
| Transmembrane interaction |
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Definition
drug binding to extracellular part to cause an effect intracellularly
*doesnt have to cross membrane to cause effect
eg. ion channel, linked to G-proten, enzyme with cytosolic domain |
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Term
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Definition
Sodium, Calcium, Potassium channel
-drug binds and causes channel to open or close cause or preventing influx of ions |
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Term
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Definition
| drug is lipophilic and crosses membrane to have effect |
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