Term
|
Definition
| affect ion channels and there is a slight delay of around 1ms at the synapse |
|
|
Term
| Metabotropic transmitters |
|
Definition
| initiate second messenger systems and have longer delays |
|
|
Term
|
Definition
| In response to the **, calcium channels open and calcium enters the presynaptic neuron |
|
|
Term
|
Definition
| Increased ** stimulates microtubule assembly and the vesicles move to the membrane surface of the cell |
|
|
Term
| as a response to incr intracellular Ca levels: |
|
Definition
| Vesicles fuse with the membrane and release neurotransmitter into the cleft |
|
|
Term
|
Definition
| : universal membrane trafficking protein |
|
|
Term
|
Definition
| calcium receptor in the presynaptic neuron involved in signaling vesicle release |
|
|
Term
|
Definition
| membrane protein that may have channel-like activity |
|
|
Term
|
Definition
| vesicle associated protein that attaches vesicles to the actin skeleton, inhibition of these proteins may release the vesicles to move to the membrane surface |
|
|
Term
| SNARE proteins such as synaptobrevin, syntaxin and SNAP-25 |
|
Definition
| mediate binding of vesicles to membranes |
|
|
Term
| prevent vesicles from fusing to the membrane thus no NT release |
|
Definition
|
|
Term
| gamma aminobutyric acid (GABA) |
|
Definition
| Agents such as *** can inhibit activation of the terminal bouton by opening chloride channels and hyperpolarizing the bouton thus influencing presynaptic events |
|
|
Term
|
Definition
|
|
Term
| Na channel toxin (inhibits synapse) |
|
Definition
|
|
Term
|
Definition
|
|
Term
| acetylcholine eliminated by ** |
|
Definition
|
|
Term
| biogenic amines like norepinephrine, serotonin, and dopamine cleared by *** |
|
Definition
| Reuptake then monoamine oxidases break it down |
|
|
Term
| neuropeptides cleared by ** |
|
Definition
|
|
Term
| weakness after exercise (post-synaptic NM disease) |
|
Definition
|
|
Term
| weakness after rest/sleep (think presynaptic disease) |
|
Definition
|
|
Term
| Curariform drugs (D-turbocurarine) (poison dart frogs) |
|
Definition
| block nicotinic ACh channels by competing for ACh binding site. Reduces amplitude of end plate potential therefore, no AP |
|
|
Term
|
Definition
| binds to troponin and changes its conformation which causes tropomyosin to move off of the myosin binding site on actin |
|
|
Term
|
Definition
| What is the most important component needed for muscle contraction? |
|
|
Term
|
Definition
| What is the source of calcium for regulation of skeletal muscle contraction? |
|
|
Term
| Contraction would not occur |
|
Definition
| What affect would the removal of all extracellular calcium have on skeletal muscle contraction? |
|
|
Term
| Contraction would still occur |
|
Definition
| What affect would the removal of all extracellular calcium have on skeletal muscle contraction if electrically stimulated? |
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|
