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Physio 6: Cardiac Cycle
Dr. McCumbee's Lecture on the Cardiac Cycle
42
Medical
Graduate
02/21/2011

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Term
What are the events that are typically measured during the cardiac cycle?
Definition
-aortic pressure
-let ventricular pressure
-left atrial pressure
-aortic blood flow
-left ventricular volume
-heart sounds
-venous pressure
-electrocardiogram
Term
Define cardiac cycle.
Definition
The electrical and mechanical events that occur during one complete sequence of contraction and relaxation by the heart
Term
T/F. The timing of events varies between the left and right sides of the heart.
Definition
False. The timing of events is very similar in both the left and right sides of the heart.
Term
What are the three phases that ventricular systole can be subdivided into?
Definition
-Isovolumic (isovolumetric) contraction
-Rapid ejection
-Reduced ejection
Term
What are the 4 subphases of ventricular diastole?
Definition
-Isovolumic (isovolumetric relaxation)
-rapid ventricular filling
-reduced ventricular filling (diastasis)
-atrial systole
Term
T/F. During physical activity atrial contraction has a larger contribution to ventricular volume.
Definition
True. This is due to the increase in heart rate, b/c there is less time for passive filling.
Term
What signals to increase the force of atrial contraction?
Definition
The sympathetic nervous system.
Term
When are blood volumes of the ventricle the greatest?
Definition
At the end of atrial systole and ventricular diastole--this is referred to as end-diastolic volume (EDV)
Term
On an ECG what does ventricular contraction coincide with?
Definition
The QRS complex.
Term
When do the AV valves close?
Definition
When the increase in intraventricular pressure exceeds atrial pressure.
Term
What causes the first heart sound?
Definition
S1 is caused by clsure of the AV valeves.
Term
When do the aortic and pulmonary valves open?
Definition
Aortic and pulmonary valves open when the pressure in the ventricles exceeds the pressure within the aorta and pulmonary artery.
Term
What four things take place during the paid ejections phase?
Definition
-Ventricular pressures continue to rise
-Pressure within the aorta and pulmonary arteries increase
-Blood flow from the ventricles into the aorta and pulmonary arteries peaks
-Ventricular volume decreases
Term
When is most of the stroke volume ejected from the heart?
Definition
During rapid ejection about 70% of stroke volume is ejected from the heart.
Term
Why does atrial volume increase during rapid ejection?
Definition
Atrial volume increases because venous return in ongoing and the AV valves are closed
Term
T/F Relaxation of the ventricles is signaled by repolarization.
Definition
False. Repolarization has nothing to do with relaxation
Term
What signals the start of diastole?
Definition
Closure of the aortic and pulmonary valves signals the start of diastole
Term
What causes the second heart sound, S2?
Definition
Closing of the semilunar valve.
Term
What happens to the pressure of the ventricles during isovolumic (isovolumetric) relaxation?
Definition
It rapidly declines, b/c the ventricles relax
Term
When do the aortic and pulmonary valves close?
Definition
When blood flow through the aortic and pulmonary valves slows and then reverses direction.
Term
What is the dicrotic notch or incisura? What does it correspond to?
Definition
The dicrotic notch or incisura isslight upward deflection in the aortic and pulmonary artery pressure traces that momentarily interrupt the decline in blood pressure.
Term
How can the end of ventricular systole be observed?
Definition
By the dicrotic notch or incisura in aortic or pulmonary artery pressure traces.
Term
T/F. Blood enters the ventricles during isolvolumic relaxation.
Definition
False. The AV and semilunar valves are closed so no blood can enter the ventricles during isovolumic relaxation.
Term
Whey is ventricular filling rapid during the rapid filling phase?
Definition
-B/c venous return has filled the atria prior to the opening of the AV valves
-the resistance to flow through the AV valves is very low
Term
What stage follows the rapid filling stage? What are its characteristics?
Definition
The reduced filling stage. During reduced filling the rate of passive filling slows and reaches a plateau, due to the ventricles filling and becoming less compliant.
-Aortic pressure and pulmonary artery pressure continue to fall as blood flows into the systemic and pulmonary circulations.
-Atrial systole tops off ventricular volume
Term
What is the first heart sound? What is it associated with the onset of (systole or diastole)?
Definition
The first heart sound is the closing of the AV valves. It is associated with the onset of systole.
Term
If the first heart sound is the closing of the mitral and tricuspid valve why are two sounds not heard?
Definition
Closure of the mitral valve usually occurs just prior to closure of the tricuspid valve, however the two valves close within about 0.01 sec of each other so two separate sounds are not distinguishable.
Term
What causes the second heart sound?
Definition
Closure of the semilunar valves at the end of systole.
Term
Which valve closes first during the second heart sound?
Definition
Aortic valve normally closes prior to the pulmonary valve.
Term
What is physiological splitting of the S2?
Definition
The phenomenon that occurs when a person takes a deep breath and closure of the aortic and pulmonary valve can be individually heard.
Term
When does S3 occur?
Definition
It is heard in early diastole after the opening of the AV valves. It is normal in children, but may be pathological in adults.
Term
When is the fourth heart sound heard? What does it coincide with?
Definition
The fourth heart sound is heard in late diastole and coincides with contraction of the atria. It is more common in older people and can be an indicator of ventricular stiffness.
Term
What causes a heart murmur?
Definition
Turbulent blood flow.
Term
What conditions can generate a murmur (5)?
Definition
-partial obstruction (stenosis)
-increased blood flow through normal structures
-regurgitation through an incompetent valve
-ejection into a dilated chamber
-abnormal shunting of blood from one chamber to a lower pressure chamber (ex. septal defect)
Term
Define bruits.
Definition
Sounds created by turbulent blood flow in blood vessels.
Term
How can pressure changes of in the right atrium be observed by a clinician?
Definition
By observing the distention of the internal jugular vein caused by the retrograde flow of blood.
Term
What waves are associated with the venous pulse curve obtained from the jugular vein?
Definition
-a wave
-c wave
-v wave
Term
What produces the a wave of venous pulse?
Definition
The a wave is charted as an upward deflection and is produced by atrial systole. Disruption of venous flow into the right atrium can also contribue to the a wave.
Term
What events produce the c wave of venous pulse?
Definition
Produced when the tricuspid valves close and bulge into the right atrium at the onset of isovolumetric ventricular contraction.
Term
How is the V wave charted and what events are associated with it in venous pulse?
Definition
The v wave (venous collection)- is charted as an upward deflection and is caused by filling of the right atrium behind the closed tricuspid valve. When the tricuspid valve opens after ventricular systole the wave drops as blood in the atrium moves into the ventricle.
Term
What effect does an increased heart rate have on the percentage of time the heart spends in diastole/systole?
Definition
At a resting heart rate (75 bpm) the heart spends more time in diastole then systole. At a heart rate of 200 bpm the time in diastole is equal to the time in systole.
Term
What is tachycardia and what are two clinical implications of tachycardia?
Definition
Tachycardia is increased heart rate and leads to a reduced duration of diastole.
This means:
-there is less time for venous return which reduces cardiac input
-perfusion of the myocardium is less effective
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