Term
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Definition
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Term
| Possible thearies for autoimmunity |
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Definition
antigenic mimicry-look similar to pathogen antibodys
T cell problems - bad thymus
Genetic factor
B cell problems |
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Term
| examples of autoimmune disorders |
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Definition
type 1 diabetes
rheumatoid athritis
graves disease
narcolepsy |
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Term
What is the WHY
What is the HOW |
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Definition
autoimmunity
hypersensitivity- normal response overboard |
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Term
| Explain Type 1 Hypersensititivy |
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Definition
Immediate
Involves IgE
dumps histamine systemically
rash, hives, cold like
atopic- genetic predisposition |
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Term
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Definition
| when a rxn becomes systemic |
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Term
| What does epinephrine do? |
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Definition
restrict blood vessels
open airways |
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Term
| Describe type 2 hypersensitivity |
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Definition
tissue specific
isoimmunity- tissue transplant gone bad
Bad blood transfusions
fevers, chills, tachycardia
anaphalyxis, shock death |
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Term
| What is hemolytic disease of newborns |
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Definition
Type II hypersensitvity
moms immune system attacks fetus
mom Rh- baby Rh + |
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Term
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Definition
| auto immune disorders (II)weak muscles |
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Term
|
Definition
type II auto immune disorders
antibodies build up on thyroid gland |
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Term
| What is hyperacute graft rejection? |
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Definition
Type II auto immune D.
lysis of donor tissue |
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Term
| Explain type III hypersensitivity |
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Definition
can take days
caused by persistant low grade infection
or extrinsic materials, ex: mold
hurts kidneys, reduced urine production |
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Term
|
Definition
type III hypersensitivity
damages connective tissue, collagen rich tissues,
Snowball effect- cycles of exhaserbation & remission |
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Term
| explain type IV hypersensitivity |
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Definition
T cell mediated
slow onset |
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Term
| What is cutaneous basophil hypersensitivity? |
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Definition
rapid type IV
skin graft gone bad |
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Term
| what is contact hypersensitivity? |
|
Definition
Type IV
skin rxn to plants, clothes, dyes...ect..
red itchy skin
TYPE IV |
|
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Term
| what is tuberculin hypersensitivity? |
|
Definition
TB rxn!
red, hard, enflamed
TYPE IV |
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Term
| What is Granulomatous hypersensitivity |
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Definition
TYPE IV
ball of immune system cells around antigen cuz it cant get broken down |
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Term
| What is a primary deficient immune response? |
|
Definition
born with or aquired
decrease in immune system
Ex: born w/o ability to make B cells |
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Term
| What is a secondary deficient immune response? |
|
Definition
consequence of treatment
Ex: chemo |
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Term
|
Definition
severe combined imunodeficiency disorder
B & T cell combined
X linked
cured with gene therapy
defect in MHC- body cant tell self appart |
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Term
| What is Wiskott-Aldrich Syndrome? |
|
Definition
b & T cell combined disorders
x linked
WASP gene mutation
not enough platelets, T cells non functional. |
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Term
| What is DiGeorge Syndrome? |
|
Definition
Thymus does not develop properly
T cell disorder
total loss of thymus.
similar to SCID |
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Term
| What is Chronic Mucocutaneous Candidasis? |
|
Definition
cant fight off candida albicans
T cell disorder
persistant skin, nail & mucus infections |
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Term
|
Definition
IgAs dont turn into plasma cells
genetic
Musosa areas, respiratory issues, |
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Term
| What is Bruton X linked agammaglobulimemia |
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Definition
B cells cant mature
increase of T cells
lots of bacterial infections |
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Term
| What is Transient Hypogammaglobulmia |
|
Definition
Slow to acquire normal Ig levels,
immune system takes a while to develop |
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Term
| What are some secondary causes of immunodeficiency |
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Definition
ages
drugs
surgery
nutrition |
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