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PHR 7470 Hypertension Drugs
Drugs, classes and mechanisms
62
Medical
Professional
10/18/2015

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Term
thiazide diuretics
Definition
MOA: inhibit the sodium-chloride transporter in the distal convoluted tubule
Term
loop diuretics
Definition
MOA: inhibit the sodium-potassium-chloride cotransporter in the thick ascending limb
Term
potassium-sparing diuretics
Definition
MOA: antagonize the effect of aldosterone or inhibit sodium transport in the collecting duct
Term
carbonic anhydrase inhibitors
Definition
MOA: inhibit carbonic anhydrase in the proximal convoluted tubule
Term
furosemide
Definition
loop diuretic (sulfonamide derivative)
Term
bumetanide
Definition
loop diuretic (sulfonamide derivative)
Term
torsemide
Definition
loop diuretic (sulfonamide derivative)
Term
ethacrynic acid
Definition
loop diuretic (non-sulfonamide)
Term
hydrochlorothiazide
Definition
thiazide diuretic (sulfonamide derivative)
Term
chlorothiazide
Definition
thiazide diuretic
Term
chlorthalidone
Definition
thiazide diuretic
Term
spironolactone
Definition
potassium-sparing diuretic (aldosterone antagonist)
Term
eplerenone
Definition
potassium-sparing diuretic (aldosterone antagonist)
Term
triamterene
Definition
potassium-sparing diuretic (sodium transport inhibitors)
Term
amiloride
Definition
potassium-sparing diuretic (sodium transport inhibitors)
Term
centrally acting sympatholytic agents
Definition
MOA: block sympathetic activity within the brain
Term
ganglion-blocking agents
Definition
MOA: inhibit the neurotransmission within autonomic ganglia by blocking nicotinic receptors
Term
adrenergic nerve terminal blockers
Definition
MOA: reduce NE release at the sympathetic nerve terminal
Term
adrenoceptor antagonists
Definition
MOA: block postsynaptic alpha or beta adrenoceptors
Term
clonidine
Definition
centrally acting sympatholytic agent (a2-agonist)
Term
reserpine
Definition
adrenergic nerve terminal blocker
Term
prazosin
Definition
adrenoceptor antagonist (a1-blocker)
Term
terazosin
Definition
adrenoceptor antagonist (a1-blocker)
Term
doxazosin
Definition
adrenoceptor antagonist (a1-blocker)
Term
phentolamine
Definition
adrenoceptor antagonist (non-selective a1-blocker)
Term
phenoxybenzamine
Definition
adrenoceptor antagonist (non-selective a1-blocker)
Term
propranolol
Definition
adrenoceptor antagonist (non-selective B-blocker)
Term
metoprolol
Definition
adrenoceptor antagonist (selective B1-blocker)
Term
atenolol
Definition
adrenoceptor antagonist (selective B1-blocker)
Term
sotalol
Definition
adrenoceptor antagonist (B-blocker)
Term
carvedilol
Definition
adrenoceptor antagonist (B-blocker)
Term
labetalol
Definition
adrenoceptor antagonist (B-blocker)
Term
pindolol
Definition
adrenoceptor antagonist (partial B agonist)
Term
acebutolol
Definition
adrenoceptor antagonist (partial B agonist)
Term
penbutolol
Definition
adrenoceptor antagonist (partial B agonist)
Term
esmolol
Definition
adrenoceptor antagonist (B-blocker)
Term
nadolol
Definition
adrenoceptor antagonist (B-blocker)
Term
calcium channel blockers
Definition
MOA: block calcium entry into the cells by binding to L-type calcium channels in VSM or cardiac muscles
Term
nifedipine
Definition
calcium channel blocker (dihydropyridine)
Term
amlodipine
Definition
calcium channel blocker (dihydropyridine)
Term
verapamil
Definition
calcium channel blocker (non-dihydropyridine)
Term
diltiazem
Definition
calcium channel blocker (non-dihydropyridine)
Term
minoxidil
Definition
potassium channel opener
Term
hydralazine
Definition
direct acting vasodilator
Term
potassium channel opener
Definition
MOA: stabilizes resting membrane potential by opening potassium channels
Term
direct acting vasodilator
Definition
MOA: dilates arterioles but not veins
Term
nitrodilator
Definition
MOA: release NO in the blood which dilates VSM, inhibits calcium entry into the cell, activates potassium channels
Term
sodium nitroprusside
Definition
nitrodilator
Term
ACE inhibitors
Definition
MOA: block angiotensin II formation by inhibiting ACE
Term
captopril
Definition
ACE inhibitor (1st generation)
Term
enalapril
Definition
ACE inhibitor
Term
ramipril
Definition
ACE inhibitor
Term
lisinopril
Definition
ACE inhibitor
Term
fosinopril
Definition
ACE inhibitor
Term
angiotensin II receptor blocker
Definition
MOA: block angiotensin II type 1 receptors
Term
saralasin
Definition
angiotensin II receptor blocker (peptide)
Term
losartan
Definition
angiotensin II receptor blocker (non-peptide)
Term
valsartan
Definition
angiotensin II receptor blocker (non-peptide)
Term
candesartan
Definition
angiotensin II receptor blocker (non-peptide)
Term
ibesartan
Definition
angiotensin II receptor blocker
Term
olmesartan
Definition
angiotensin II receptor blocker
Term
aliskiren
Definition
renin inhibitor
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