Term
|
Definition
NSAID
covalent binding to SERINE residue of COX---> IRREVERSIBLE inhibition: COX-1---> prevents AA from binding; COX-2---> AA bound, but no PG formation
reduced NF-KB txn activity---> less txn of inflammatory mediators
Antipyresis (325-650 mg)
Anti-inflamm (2x ")
Antithrombotic (0.5x ")
TINNITUS; Reye's; Salycism (HYPERvent./alkalosis); Medullary Resp. Center Depression (HYPOvent./acidosis); Metabolic Acidosis (carb. metab. and renal dysfunction) |
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Term
| How does Aspirin lower the risk of colon cancer? |
|
Definition
| prevents formation of PGE2---> so no txn of cell growth and proliferation mediators |
|
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Term
| Propionic Acid Derivatives |
|
Definition
NSAID
REVERSIBLE COX inhibition
small doses:
Antipyresis
Analgesia
large doses:
Ant-inflamm.
better tolerated than Aspirin; NOT for moms; RASH; TINNITUS |
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Term
|
Definition
NSAIDs
REVERSIBLE COX inhibition; neutrophil migration inhibition
anti-inflamm.; ETODOLAC/KETOROLAC: perioperative pain; INDOMETHICIN: CNS effects
HEADACHE |
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Term
| Selective COX-2 Inhibitors |
|
Definition
NSAIDs
SELECTIVE COX-2 inhibitors
acute pain from OA, RA
NEVER during 3rd trimester
CV events: COX-2 block----> no PGI2---> no control of clotting
STEVENS-JOHNSON, TEN (epidermis split from dermis) |
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Term
| Para-aminophenol Derivative |
|
Definition
| Acetominophen (Tylenol)---> "cock-block when mixed with alcohol"---> Weak COX inhibitor analgesic and antipyretic only; NOT inflamm. rash and allergies, HEPATIC NECROSIS, chronic use---> RENAL FAILURE; NEVER with alcohol |
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|
Term
| List the three types of steroid hormones produced by the adrenal cortex |
|
Definition
| glucocorticoids; mineralocorticoids, adrenal androgens |
|
|
Term
| Describe the nature of steroid effects in terms of time until onset and duration. |
|
Definition
| effects are not immediate; effects last longer than plasma half-life |
|
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Term
|
Definition
free steroids--> bind GR---> nuclear translocation----> induce GRE: Lipocortin txn---> Phospholipase A2 inhibition
RA; SLE; Tendinitis/Bursitis; ASTHMA; Eczema; Inflammatory disorders in general; reduces circulating inflamm. factors;
large dosage:
electrolyte imbalance; CNS; collagen synthesis inhibition
Withdrawal: acute adrenal insufficiency; disease flare-up |
|
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Term
|
Definition
5-LOX inhibitor or CysLT-R antagonist
ASTHMA
inhibitor:
NEVER with alcohol; increased liver enzymes
R-antagonist:
CYP450 inhibition |
|
|
Term
|
Definition
IgG-infusion R for circulating TNF
reduces TNF available to activate NFKB and other inflammatory factors
CANCER, vasculitis, liver disease, FUNGAL infx; TB |
|
|
Term
| Which two IL's are anti-inflammatory cytokines? |
|
Definition
|
|
Term
|
Definition
Ab IL-6 receptor antagonist
RA joint tenderness reduction |
|
|
Term
|
Definition
IL-6 R-Antagonist
reduces RA jt tenderness |
|
|
Term
|
Definition
inhibits diydro-orotate hydrogenase---> reduces PYRIMIDINE synthesis
"L=L": blocks LYMPHOCYTE replication; larger doses---> reduces other inflamm. factrs
liver tox (cause of long t1/2 through ENTEROHEPATIC CYCLING); weight loss; HTN |
|
|
Term
|
Definition
| "sounds like hydrocholic acid"--> reduces intracellular pH---> decreased inflamm. cell function |
|
|
Term
|
Definition
| metabolite: 6-mercaptopurine---> inhibits PURINE synthesis |
|
|
Term
|
Definition
| "Omar had allergies"--> binds IgE---> inhibits allergic response |
|
|
Term
|
Definition
"Gladiator-strength to bind to MHCII itself"--> binds MHCII---> prevents MYELIN Ag presentation to T-cells
Tx: "Gladiator fights on"---> MS |
|
|
Term
|
Definition
| "cortisol from body"---> ENDOGENOUS neuropeptide---> binds immune cells |
|
|
Term
|
Definition
"11-year-old Evan scratched himself up by falling while carrying CDs"---> binds CD11a
Tx: Psoriasis |
|
|
Term
|
Definition
binds costimulus ligands: CD80/86)---> "interCEPTs"--> CD28 of its costimulus---> no T-cell activation ("Aba sounds like Ana"---> ANERGY instead)---> NO B-cell-induced autoimmune Ig production!
inhibits RADIOGRAPHIC progression of RA
headache, NASOPHARYNGITIS, naeusea |
|
|
Term
|
Definition
"chicin"---> Gout
blks: LEUKOCYTE migration/activation; mitotic spindle formation 1st line for ACUTE gout; NEVER with hepatic, renal, CV disease; NEVER during pregnancy GI and diarrhea |
|
|
Term
| Allopurinol and Febuxostat |
|
Definition
Gout "all pure so no more xenobiotic meats"---> blks: XANTHINE OXIDASE---> no uric acid synthesis;
"all pure so can get along w/ anyone"---> CAN use during SALICYLATE therapy RASH |
|
|
Term
| Uricosuric Agents (Sulfinpyrazone; Probenicid) |
|
Definition
Gout
blks: "pyrate hijacks ship (transporter)"---> URAT1 reabsorption transporter---> no reabsorption at kidneys
INEFFECTIVE with salicylate therapy; NEVER with kidney stones
PLATELET inhibition; NEVER if allergic to PHENYLBUTAZONE (SULFINPYRAZONE-like structure) |
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