Term
|
Definition
| nephrotoxic; hearing loss |
|
|
Term
|
Definition
| nephrotoxic; limited to topical use |
|
|
Term
|
Definition
|
|
Term
|
Definition
| irritation at injection site; GI irritation; bone marrow supression; renal toxicity (esp + aminoglycoside) |
|
|
Term
|
Definition
| GI upset; bone marrow supression |
|
|
Term
|
Definition
|
|
Term
| Polymyxin (Amphotericin B) |
|
Definition
| nephrotoxic; GI upset; lipid-based---> less toxic |
|
|
Term
|
Definition
|
|
Term
|
Definition
| GI upset; inhibition of CYT-P450-mediated metabolism of other drugs |
|
|
Term
| Azole Antifungals (Ketoconazole) |
|
Definition
| decrease in steroid biosynthesis; GI upset; inhibition of CYT-P450-mediated metabolism of other drugs |
|
|
Term
| 5-Fluorocytosine Antifungals |
|
Definition
| bone marrow supression---> mild anemia, but reversible |
|
|
Term
|
Definition
| GI upset; CNS excitement, cartilage damage (esp KIDS < 17) |
|
|
Term
|
Definition
| induces metabolism of other drugs; teratogenic (bad for MOMS); GI upset |
|
|
Term
|
Definition
nephrotoxic (esp with CEPHALOSPORIN); ototoxicity; auditory toxicity; blocks NMJ;
Precautions: hydration; avoid CEPHALOSPORINS |
|
|
Term
|
Definition
| GI; hepatotoxicity; DISCOLORATION of teeth; crosses placenta and in breast milk; SUPERINFECTION if natural flora is disturbed; PHOTOTOXICITY |
|
|
Term
|
Definition
| infants cannot conjugate---> CV toxicity; bone marrow suppression; aplastic anemia |
|
|
Term
| Macrolides (Erythromycin) |
|
Definition
| MILD liver and GI toxicity |
|
|
Term
| Macrolides (Telithromycin) |
|
Definition
| SEVERE HEPATIC TOXICITY---> limited to RTI; GI upset; headache; blurred vision; altered taste perception |
|
|
Term
|
Definition
| MILD GI upset; SEVERE GI irritation; RARE bone marrow supression |
|
|
Term
| Quinupristin/Dalfopristin |
|
Definition
| at site of injection: pain, inflammation, edema, THROMBOPHLEBITIS; arthralgia, and myalgias |
|
|
Term
|
Definition
| mild GI upset; thrombocytopenia (reversible) |
|
|
Term
|
Definition
CRYSTALURIA; liver toxicity; decreased bone marrow function---> anemia
Precautions: hydration; Na bicarbonate to alkalinize urine) |
|
|
Term
|
Definition
| bone marrow depression; GI upset |
|
|
Term
|
Definition
| nausea, vomiting, diarrhea; headache, PULMONARY FIBROSIS (rare); urine---> BROWN |
|
|
Term
|
Definition
| NOT used with SULFONAMIDES (which are less soluble in acidic urine!) |
|
|
Term
|
Definition
| nauseau; vomiting, diarrhea, edema, muscle cramps, rash, neutropenia, and thrombocytopenia |
|
|
Term
| Alkylating Agent (Chlorambucil) |
|
Definition
| least toxic of this group |
|
|
Term
| Alkylating Agent (Cyclophosphamide) |
|
Definition
|
|
Term
| Alkylating Agent (BUSULFAN) |
|
Definition
| relatively mild GI toxicity |
|
|
Term
| Antimetabolite (Folic Acid Analog: Methotrexate) |
|
Definition
| systemic admin of FOLINIC ACID---> metabolized to THF without reductase enzyme---> rescue from toxicity |
|
|
Term
| Antimetabolite (pyrimidine analog: 5-FU) |
|
Definition
|
|
Term
| natural anticancer drugs from plants (Vinca Alkaloids: Vincristine) |
|
Definition
| MINIMAL MYELO-SUPPRESSION (unlike Vinblastine); CNS toxicity---> progressive weakness, tremors, convulsions |
|
|
Term
| natural anticancer drugs from plants (Vinca Alkaloids: Vinblastine) |
|
Definition
| MYELOSUPPRESSIVE; LESS neurotoxicity (unlike Vincristine) |
|
|
Term
| natural antibiotics (Actinomycin D) |
|
Definition
|
|
Term
| natural antibiotics (Bleomycin) |
|
Definition
| pulmonary fibrosis (2-5%) |
|
|
Term
| natural antibiotics (Doxorubcin (Adriamycin)) |
|
Definition
| cardiac toxicity; hair loss |
|
|
Term
| antiandrogens (Flutamide) |
|
Definition
| gyenecomastia; nausea/vomiting; |
|
|
Term
|
Definition
renal toxicity
Precaution: hydration; manitol diuresis---> lowers concentration in kidney |
|
|
Term
| antiviral (DNA viruses, nonretroviral): Antiherpes Virus (Acyclovir) |
|
Definition
| MILD GI; headache; renal toxicity |
|
|
Term
| antiviral (DNA viruses, nonretroviral): Antiherpes Virus (Gancyclovir) |
|
Definition
| bone marrow; CNS; teratogenic (MORE INCORPORATED to DNA than Acyclovir) |
|
|
Term
| antiviral (nonretroviral): Antiinfluenza (Amantadine) |
|
Definition
| minor GI; CNS---> nervous; light headed; lack of concentration |
|
|
Term
| antiviral (nonretroviral): Antiinfluenza (Oseltamavir) |
|
Definition
|
|
Term
| antiviral (nonretroviral): Antiinfluenza (Zanamivir) |
|
Definition
| well tolerated; some wheezing/bronchospasm |
|
|
Term
| antiviral (nonretroviral): Interferons |
|
Definition
| fever, chills, headache, bone marrow depression; CNS - confusion |
|
|
Term
| antiviral (nonretroviral): Lamivudine |
|
Definition
|
|
Term
| antiretroviral: Zidovudine (AZT) |
|
Definition
| fatigue, nausea, headache, anemia |
|
|
Term
| antiretroviral: Nevirapine |
|
Definition
| rash, fever, fatigue, nausea, liver toxicity |
|
|
Term
| antiretroviral: Efavirenz |
|
Definition
| CNS toxicity---> lack of focus; dreams; headache; dizzyness; rash |
|
|
Term
| antiretroviral: Atazanavir; Idinavir |
|
Definition
| CYTP450 inhibition---> blocks drug metabolism overall |
|
|
