Term
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Definition
Phase I
Types of reactions: Oxidative metabolism, reductive metabolism, hydroxylation
Location: Smooth ER membrane in liver or small intestine
Cofactors: Heme, Oxygen, water |
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Term
|
Definition
Phase I
Reduction
Smooth ER membrane
Cofactors: NADPH |
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Term
| Flaving containing Monooxygenases |
|
Definition
FMO's
Phase I
Oxidative metabolism, hydroxylation, amine oxidation, dehydrogenations
Found in liver
Cofactor: Oxygen |
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Term
|
Definition
Phase I
Hydrolytic
Located in cytosol
No cofactors |
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Term
|
Definition
Phase I
Hydrolysis, Detoxify or metabolically activated drugs, environmental toxins and carcinogens
Located in ER, cytosol, and plasma |
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Term
| UDP glucoronsyl Transferase |
|
Definition
Phase II
Conjugation
ER cytosolic, UDP glucoronsyl |
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Term
|
Definition
Phase II
Conjugation
Cytosolic
Cofactor: Acetyl CoA |
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Term
|
Definition
Phase II
Conjugation
Cytosol, Smooth ER
Cofactor: Glutathione |
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Term
|
Definition
Phase II
Conjugation
Found in cytosol
Cofactor: SAM |
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Term
|
Definition
Phase II
Conjugation
Cytosol
Cofactor: PABS |
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|
