Term
| Muscle Relaxants on the Spinal Cord |
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Definition
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Term
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Definition
Centrally Acting Muscle relaxant
Blocks nerve impulse transmission in the spinal cord
Uses: Tx. of acute inflammatory and traumatic conditions of the skeletal muscles, and reduce muscular spasm.
IV only in horses. Dog/ Cat: IV and PO |
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Term
| Guaifenesin (Glycerol Guaicolate) |
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Definition
Centrally acting muscle relaxant (horses)blocks nerve impulses in spinal cord, brain stem and subcortical areas of brain.
Some sedative and analgesic effects
DOA: 10-20 min.
Used for intubation (relaxes pharyngeal and laryngeal m. )Can be combined with Ketamine.
May cause vasodilation, hypotension, and tachycardia. High conc. will cause hemolysis (10%). cattle more sensative |
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Term
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Definition
Acts directly on skel.m. cell by inhibiting release of Ca from sarcoplasmic reticulum
Uses: Tx. of malignant hyperthermia (due to inhalation anesthetics), may lower intraurethral pressure in male cats w/ obstructive lower UT dz. |
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Term
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Definition
Cause relaxation of skeletal muscles with no CNS effect
Use artificial respiration with O2 as antidote
Depolarizing and Non-Depolarizing |
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Term
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Definition
Depolarizing NM blocker
Phase 1 block (depolarizing: binds to N receptors) Persistent depolarization--> flaccid paralysis. Phase II block (desensitization).
Poor lipid soluble, Highly Ionized. Rapid onset, short duration. First causes contraction, then relaxation. Causes: relaxation of m. of face, glottis, intercostals and diaphragm. Hypertension, Bradycardia, hyperkalemia
weak histamine release. Rapidly metabolized |
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Term
| Non-depolarizing n.m. blockers |
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Definition
Binds and Blocks. Reversed with Neostigmine, Edrophonium. Isoquinolone derivatives (atraqurium, tubocurarine, cistracurium)
Steroid derivative (Pancuronium, Vercuronium) |
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