Term
|
Definition
| rapid-acting insulin (peak ~1hr) |
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Term
|
Definition
| rapid-acting insulin (peak ~1hr) |
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|
Term
|
Definition
| short-acting insulin (peak ~3hr) |
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|
Term
|
Definition
| intermediate-acting insulin (peak ~8hr) |
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|
Term
|
Definition
| long-acting insulin (no peak!!) |
|
|
Term
|
Definition
| long-acting insulin (peak ~9hr) |
|
|
Term
|
Definition
first generation sulfonylureas
close K+ channel --> increased insulin release
disulfiram-like |
|
|
Term
|
Definition
first generation sulfonylureas
close K+ channel --> increased insulin release
disulfiram-like |
|
|
Term
|
Definition
second generation sulfonylureas
close K+ channel --> increased insulin release |
|
|
Term
|
Definition
second generation sulfonylureas
close K+ channel --> increased insulin release |
|
|
Term
|
Definition
second generation sulfonylureas
close K+ channel --> increased insulin release |
|
|
Term
|
Definition
biguanides
decrease gluconeogenesis, increase insulin sensitivity
NO hypoglycemia
lactic acidosis, renally excreted (check Cr!) |
|
|
Term
|
Definition
glitazones/TZD
binds PPAR-gamma nuclear transcription regulator --> increase insulin sensitivity
edema, hepatotoxicity |
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|
Term
|
Definition
glitazones/TZD
binds PPAR-gamma nuclear transcription regulator --> increase insulin sensitivity
edema, hepatotoxicity |
|
|
Term
|
Definition
glitazones/TZD
binds PPAR-gamma nuclear transcription regulator --> increase insulin sensitivity
edema, hepatotoxicity |
|
|
Term
|
Definition
| alpha-glucosidase inhibitor --> decreased digestion of sugars in GI |
|
|
Term
|
Definition
| alpha-glucosidase inhibitor --> decreased digestion of sugars in GI |
|
|
Term
|
Definition
| mimics amylin --> decreased glucagon |
|
|
Term
|
Definition
GLP-1 analog --> increase insulin secretion
pancreatitis |
|
|
Term
|
Definition
| meglitinides -- bind K+ channel in beta-cells --> increased insulin release |
|
|
Term
|
Definition
| meglitinides -- bind K+ channel in beta-cells --> increased insulin release |
|
|
Term
|
Definition
| DDP-4 inhibitors -- decreased GLP-1 degradation |
|
|
Term
|
Definition
| DDP-4 inhibitors -- decreased GLP-1 degradation |
|
|
Term
PTU, methimazole side effects
PTU vs. methimazole in pregnancy/ |
|
Definition
agranulocytosis, aplastic anemia
use PTU in pregnancy!! |
|
|
Term
|
Definition
somatostatin analog
acromegaly, carcinoid, gastrinoma, glucagonoma, VIPoma, acute variceal bleeds |
|
|
Term
|
Definition
|
|
Term
|
Definition
| inhibit phospholipase A2, decreased expression of COX-2, inactivates NF-kB (transcription factor that induces prod of TNF-alpha) |
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