Term
| What are examples of somatic (nonpharmacologic) therapies for MDD? |
|
Definition
| Electroconvulsive therapy, transcranial magnetic stimulation, light therapy |
|
|
Term
| How long does it usually take to see the effects of an antidepressant? |
|
Definition
|
|
Term
| T/F: There is a black box warning on all antidepressants for increased SI in pts older than 24 y.o. |
|
Definition
| False- this warning applies to children, adolescents, and young adults (18-24) |
|
|
Term
|
Definition
| Non-selective inhibition of 5HT and NE reuptake |
|
|
Term
| Which TCA causes the most QT prolongation? |
|
Definition
| Imipramine, followed by amitryptyline |
|
|
Term
| Which are associated w/ more side fx, tertiary or secondary amines? |
|
Definition
| Tertiary (e.g. imipramine, amitryptyline) |
|
|
Term
| Which TCA is commonly prescribed at low doses as a sleep aid? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Phenelzine, tranylcypromine, isocarboxazid, selegiline patch (no dietary restrictions <6mg dose) |
|
|
Term
| What is the risk of eating tyramine-containing foods with MAOis? |
|
Definition
|
|
Term
| Are MAOis reversible or irreversible? |
|
Definition
|
|
Term
|
Definition
| Citalopram, escitalopram (S-enantiomer of citalopram), fluoxetine, paroxetine, sertraline, fluvoxamine |
|
|
Term
| Which SSRI has the most risk of QT prolongation and therefore a max dose in pts. >65 |
|
Definition
|
|
Term
| Which SSRI has most anti-cholinergic sfx? |
|
Definition
|
|
Term
| Which SSRI has highest risk of discontinuation syndrome? |
|
Definition
|
|
Term
| Which SSRI has highest risk of GI effects? |
|
Definition
|
|
Term
| Which SSRI has the longest half-life and thus does not need to be tapered down? |
|
Definition
|
|
Term
| Which SSRI is used to treat OCD? |
|
Definition
|
|
Term
| Which SSRI is pregnancy category D? |
|
Definition
| Paroxetine (the rest are category C) |
|
|
Term
|
Definition
| Venlafaxine, desvenlafaxine (active metabolite of venlafaxine), levomilnacipran, duloxetine |
|
|
Term
| Which SNRI is associated w/ dose-related HTN? |
|
Definition
|
|
Term
| What labs do you need to monitor in pts taking duloxetine? |
|
Definition
|
|
Term
| What is the pregnancy category for SNRIs? |
|
Definition
|
|
Term
|
Definition
| Alpha-2 antagonist; increases synaptic concentration of 5HT and NE |
|
|
Term
| What 2 antidepressants should you consider in pts needing appetite stimulation/weight gain? |
|
Definition
|
|
Term
|
Definition
| Blocks reuptake of NE and DA (No 5HT effects) |
|
|
Term
| Which antidepressant is considered "activating"? |
|
Definition
|
|
Term
| Which antidepressant is not associated w/ sexual dysfunction? |
|
Definition
|
|
Term
| Which antidepressant has dose-related risk of seizures? |
|
Definition
| buproprion (avoid in pts w/ ED, drug withdrawal) |
|
|
Term
|
Definition
| Weak 5HT reuptake inhibitor; significant histamine blocker- SEDATION |
|
|
Term
| Which newer antidepressant needs to be taken w/ food and can lead to GI upset? |
|
Definition
|
|
Term
| Which antidepressant is no longer used due to high risk of hepatotoxicity? |
|
Definition
|
|
Term
| Which antidepressant is approved in smoking cessation? |
|
Definition
|
|
Term
| How long does it take to start seeing non-antidepressant fx of antidepressants? |
|
Definition
|
|
Term
| Which antidepressant can be used for antiemetic fx? |
|
Definition
|
|
Term
| What is the first-line treatment in anxiety? |
|
Definition
| CBT (cognitive behavioral therapy) + SSRI or SNRI |
|
|
Term
| T/F: benzos bind to GABA receptor |
|
Definition
| False: they bind at gamma subunit, causing conformational change that increases GABA binding (allosteric modulation) |
|
|
Term
| What are the current uses of barbiturates, and some examples? |
|
Definition
| Sedative-hypnotic/anticonvulsant; phenobarbital, secobarbital, primidone |
|
|
Term
|
Definition
| Allows chloride ion to enter cell, hyperpolarizing and inhibiting action potential |
|
|
Term
| What are some ultra-short acting BZDs? |
|
Definition
| Midazolam, clorazepate- used in ICU as IV sedative |
|
|
Term
|
Definition
|
|
Term
| Intermediate-acting BZDs (highest risk for abuse- euphoria)? |
|
Definition
| Alprazolam, estazolam, temazepam, oxazepam, lorazepam |
|
|
Term
|
Definition
| Diazepam, flurazepam, quazepam, clonazepam |
|
|
Term
| Which BZD agents are used in elderly pts w/ hepatic impairment? |
|
Definition
| Lorazepam, Oxazepam, Temazepam |
|
|
Term
| Which anxiolytic is similar to Benadryl (antihistamine)? |
|
Definition
|
|
Term
| Which anxiolytic med takes several weeks to see effect? |
|
Definition
|
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