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Pharm -- Adrenergic and Cholinergic
First Aid 2012 pp264-269
49
Medical
Graduate
02/09/2013

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Term
epinephrine
Definition
alpha1/2, beta1/2-agonist
anaphylaxis, glaucoma, asthma, hypotension
Term
norepinephrine
Definition
alpha1/2, (some beta1)-agonist
hypotension
Term
isoproterenol
Definition
beta1 and beta2-agonist
AV block (rare), asthma (rare)
Term
dopamine
Definition
low dose -- D1 agonist
medium dose -- beta1, (some beta2)-agonist
high dose -- alpha1/2 agonist
shock (renal perfusion), heart failure, inotropic and chronotropic
Term
dobutamine
Definition
beta1-agonist
inotropic and chronotropic, cardiac stress test, heart failure
Term
phenylephrine
Definition
alpha1-agonist
pupillary dilation, vasoconstriction, nasal decongesetion
Term
midodrine
Definition
alpha1-agonist
hepatorenal syndrome, orthostatic hypotension
Term
fenoldopam
Definition
D1 agonist
malignant HTN
Term
metaproterenol
Definition
beta2 agonist
acute asthma
Term
terbutaline
Definition
beta2 agonist
stop uterine contractions
Term
ritodrine
Definition
beta2 agonist
stop uterine contraction
Term
hemicholinium
Definition
prevents choline re-uptake
Term
vesamicol
Definition
prevents ACh storage in vesicles
Term
metyrosin
Definition
inhibit tyrosine --> DOPA
Term
reserpine
Definition
inhibits storage of NE, DA, 5-HT in vesicles
Term
cocaine
Definition
inhibits reuptake of NE, E, DA
Term
amphetamine
Definition
releases stored NE, E, DA
Term
guanethidine
Definition
inhibits NE release
Term
bethanechol
Definition
direct muscarinic agonist
for ileus, urinary retention
Term
carbachol
Definition
direct muscarinic agonist
glaucoma
Term
pilocarpine
Definition
direct muscarinic agonist
emergency glaucoma!!
Term
methacholine
Definition
direct muscarinic agonist
challenege for asthma diagnosis
Term
neostigmine
Definition
indirect muscarinic agonist
ileus, urinary retention, myasthenia gravis, reversal of neuromuscular junction block
Term
pyridostigmine
Definition
indirect muscarinic agonist
myasthenia gravis
Term
edrophonium
Definition
indirect muscarinic agonist
diagnosis of myasthenia gravis
Term
physostigmine
Definition
indirect muscarinic agonist
crosses BBB!! --> tx atropine overdose, glaucoma
Term
echothiophate
Definition
indirect muscarinic agonist
glaucoma
Term
donepezil
Definition
indirect muscarinic agonist
Alzheimer's
Term
organophosphates
Definition
irreversible AChE inhibitors
insecticide/farmer, "nerve gas"
parathion, malathion

DUMBBELSS
Diarrhea
Urination
Miosis
Bradycardia
Bronchospasm
Excitaiton of muscles and CNS
Lacrimation
Sweating
Salivation
Term
ephedrine
Definition
releases stored NE, E
Term
clonidine
Definition
centrally acting alpha2 agonist (no decreased renal flow!)
Term
metyldopa
Definition
centrally acting alpha2 agonist (no decreased renal flow!)
Term
phnoxybenzamine
Definition
irreversible non-selective alpha-blocker
pheochromocytoma
Term
phentolamine
Definition
reversible non-selective alpha-blocker
for MAOi hypertensive crisis (tyramine)
Term
-zosin
Definition
alpha1-blocker
for HTN and BPH
Term
mirtazapine
Definition
alpha2-blocker
increase NE and 5-HT secretion (for depression)
Term
beta-blockers that are partial beta agonists
Definition
PAPA (Partial Agonist)
Pindolol
Acebutolol
** contra-indicated in angina!! **
Term
atropine
Definition
muscarinic antagonist for everything!!!
Term
homatropine
Definition
muscarinic antagonist
eye -- mydriasis, cycloplegia
Term
tropicamide
Definition
muscarinic antagonist
eye -- mydriasis, cycloplegia
Term
benztropine
Definition
muscarinic antagonist
CNS -- Parkinson's
Term
scopolamine
Definition
muscarinic antagonist
CNS -- motion sickness
Term
ipratropium
Definition
muscarinic antagonist
resp -- asthma/COPD
Term
oxybutynin
Definition
muscarinic antagonist
GU -- stop urge incontinence
Term
glycopyrrolate
Definition
muscarinic antagonist
GU -- stop urge incontinence
Term
methscopolamine
Definition
muscarinic antagonist
GI/GU -- peptic ulcer, urinary incontinence
Term
pirenzepine
Definition
muscarinic antagonist
GI/GU -- peptic ulcer, urinary incontinence
Term
propantheline
Definition
muscarinic antagonist
GI/GU -- peptic ulcer, urinary incontinence
Term
"garderner's mydriasis"
Definition
Jimson weed similar to atropine toxicity
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