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Pharmacotherapy Exam 1
Cyp enzymes
17
Pharmacology
Graduate
09/19/2012

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Cards

Term
Inhibitors of Cyp3A4
Definition
Ketoconazole
itraconazole
erythromycin
verampamil
grape fruit juice
fluoxetine (weak-moderate)
fluvoxamine (moderate)
Nefazodone (strong)
Term
inducers of 3A4
Definition
phenytoin
carbamazepine
rifampin
St. John's Wort
Term
PGp inducers
Definition
Rifampin
St. John's Wort
Phenobarbital
phenytoin
carbamazepine(?)
Term
PGP inhibitors
Definition
verapamil
diltiazem
nifedipine
felodipine
clarithromycin
erythromycin
itraconazole
ketoconazole
cyclosporine
tacrolimus
quinidine
amiodarone
talinolol
tamoxifen
testosterone
Term
hepatic inducers: Broad spectrum inducers
Definition
Cyp1A2, Cyp2C, Cyp3A and UGT
Carbamazepine, phenytoin, phenobarbital, rifampin
Term
Hepatic inducers: selective Cyp3A inducers
Definition
felbamate
topiramate
oxcarbazepine
griseofulvin
nevirapine
St. John's Wort.
Term
Hepatic Inducers: selective Cyp1A2 inducers
Definition
Smoking!
Term
Hepatic Inducers: selective Cyp2E1 inducers
Definition
Alcohol
Term
Hepatic inducers: Selective UGT inducers
Definition
lamotrigine
oxcarbazepine
Oral contraceptives
Term
Cyp 2D6 inhibitors
Definition
duloxetine
quinidine
paroxetine
fluoxetine/norfluoxetine
ritonavir
Amiodarone
chlorquine
diphenhydramine
sertramine (weak-moderate)
Term
Inhibitors of Cyp3A4
Definition
erythromycin
cimetidine
clarithromycin
diltiazem
fluconazole
grapefruit juice
isonazid
itraconazole
ketoconazole
miconazole
propoxyphene
ritonivir
troleandomycin
verapamil
fluoxetine (weak-moderate)
fluvoxamine (moderate)
Nefazodone (strong), vilazodone
Term
Inhibitors of UGT
Definition
Valproate
Term
inhibitors of 2c19
Definition
fluoxetine
fluvoxamine
Term
inhibitors of 2cp
Definition
fluoxetine (moderate)
Term
inhibitors of 1A2
Definition
fluvoxamine (strong)
Term
inhibitors of cyp2c9
Definition
fluvoxamine (moderate)
Term
inihibitors of 2C8
Definition
vilazodone
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